Original Wuyuan Li Na and other SIFIC infection horizons　

Author: Wu Yuan Li Na Jin Wenting Ma Yuyan

Review: Hu Bijie and Pan Jue

First, a brief introduction to medical history

Male, 63 years old, from Shanghai, was admitted to the Infectious Diseases Department of Zhongshan Hospital for the second time on November 23, 2022.

Chief complaint: indwelling catheterization with repeated urine color turbidity for 2 months and then 8 days.

Current medical history:

On September 19, 2022, I went to a hospital in Shanghai for fatigue, anorexia and dysuria. WBC 10.12×10 9/L, N 87.6%, Hb 53g/L, hsCRP 135.22mg/L, ESR 62mm/H, albumin 30.1g/L, Scr 589μmol/L, K 2 were examined. Urine routine: WBC 3892/ul, occult blood 3+/RBC 5579/ul, protein 2+; Chest CT: bilateral pleural effusion, partial atelectasis of lower lobe of both lungs; Abdominal pelvic CT: Bilateral middle and upper ureteral dilatation and renal pelvis and calyceal dilatation, the patch in the right part of calyceal is slightly high density, the bladder wall is thickened, there is a little flocculent blur around the left renal fat sac and ileocecal part, and there is a little effusion in the pelvic cavity. A large amount of turbid urine was drained by indwelling catheter. Urine culture showed that Klebsiella pneumoniae was positive. Considering urinary tract infection, acute kidney injury, hypokalemia and severe anemia, patients were given symptomatic support treatment such as anti-infection, bladder irrigation, antioxidation, potassium supplementation and blood transfusion. The symptoms of patients improved and the urine was slightly clarified. 10-18 Review urine routine: WBC3+, RBC3+, protein 1+, SCR 263 μ mol/L.

I was admitted to our department on October 19, 2022. Blood routine: WBC 5.08X10 9/L, N 66.1%, inflammatory markers: ESR 19mm/H, hsCRP 52.3mg/L, PCT 0.52ng/ml, Scr 257μmol/L, and urine routine: WBC 28493/μ. Urinary color Doppler ultrasound: hydronephrosis, bilateral ureteral dilatation, bladder wall thickening significantly; Abdominal pelvic CT: hydronephrosis of both renal pelvis and ureter, thickening of ureter wall (inflammatory change), inflammatory change of bladder and ureter may be large, the volume of both kidneys increases and the substance is thin. Meropenem 1g q12h is given for empirical anti-infection. Urology consultation considers the acute stage of infection, so it is not suitable to put double J tubes. If necessary, pyelostomy can be done, but it does not improve renal function much. Bladder irrigation is recommended. 10-20 middle-stage urine culture (sampling on October 19): Klebsiella pneumoniae was positive; 10-22 urine culture drug sensitivity: Carbapenem-resistant Klebsiella pneumoniae (CRKP), adjusted to ceftazidime and abamectin 2.5g q12h for anti-infection, and daily bladder irrigation. After treatment, the urine color of the patients gradually became clear, and the urine white blood cell and bacterial count gradually decreased during follow-up. The urine bacterial culture was negative on November 1 and November 4. Check the urine routine on November 09: WBC 28/uL, RBC 4/uL, urine protein+,bacterial count 29/UL;Blood WBC 7.64×10 9/L, N 76.5%, hs-CRP 0.4mg/L, ESR 25mm/H, PCT 0.18ng/mL, Scr 175μmol/L, which were significantly improved compared with those at admission. Stop ceftazidime and abamectin on November 11 and be discharged.

On November 15, 2022, the patient appeared turbid urine again, and there was no fever and other discomfort. On November 23, he was admitted to the hospital for a second diagnosis and treatment.

Past history: In September, 1991, T12-L1 comminuted fracture was treated with internal fixation. After operation, the catheter was retained for half a year due to urinary incontinence, and then the catheter was removed after urination. There was no urinary tract infection during this period. Diabetes for 16 years, insulin therapy, blood sugar control can be; Hypertension for 5 years, oral amlodipine to reduce blood pressure, blood pressure control can be.

Second, the admission examination (admitted on November 23, 2022)

[physical examination]

T: 36.2℃ P: 90 times/min R: 20 times/min BP: 176/105 mmHg.

Stay in bed, feel refreshed and calm, lose weight, and muscle atrophy of lower limbs; Breathing sounds in both lungs are thick, and dry and wet rales are not heard; The rhythm of the heart is regular, the abdomen is soft, without tenderness and rebound pain, without mass, without percussion pain in both kidneys, without tenderness at ureter point and rib and waist point, and the lower abdomen does not touch the enlarged bladder. During indwelling catheterization, the urine in the urine collection bag is turbid and more white flocs are deposited. Limbs are not swollen.

[Laboratory examination]

Blood routine: WBC 7.85×10 9/L, N 81.3%, HB 121g/L, PLT 170×10 9/L.

Urine routine: WBC 2775/μ l; RBC 2/μl, bacterial count: 39879/μl, nitrite positive, leukocyte esterase+++.

Inflammation markers: hs-CRP 17.9mg/L, ESR 68mm/H, PCT 0.12ng/mL.

Biochemistry: ALT/AST 23/21U/L, Alb 47g/L, Scr 199μmol/L, eGFR 30ml/min/1.73m2, na/k 140/5.5mmol/l.

Third, clinical analysis

Characteristics of medical history: middle-aged and elderly male, indwelling catheter, with repeated urinary turbidity and abnormal urine routine. Urine culture showed CRKP one month ago, and it improved after ceftazidime-ababactam treatment, but urine turbidity reappeared three days after drug withdrawal, blood inflammatory index increased, urinary leukocyte and bacterial count increased significantly, and the diagnosis of urinary tract infection was clear. The reasons for short-term recurrence after antibacterial drug treatment improved were considered:

Recurrence of CRKP infection: The patient has been indwelling catheter for 2 months, and there may be biofilm formation of catheter and abnormal urinary tract structure, which makes it difficult to completely eliminate the infection and relapse after stopping taking the drug. Therefore, urine culture and drug sensitivity test can be improved.

New infection: the patient has high risk factors of recurrent urinary tract infection, and the pathogen may be different each time. The patient’s previous CRKP infection treatment was effective, and the possibility of new pathogen infection should be considered in the short term, until the urine culture is perfect and clear.

Multiple infections: patients with abnormal urinary tract structure, indwelling catheter and other risk factors can not be removed, so it is necessary to be alert to the possibility of multiple pathogens including fungi combined with infection, repeat the cultivation of urine bacteria, mycoplasma, fungi and mycobacteria, and improve urine mNGS to help clarify the infected pathogens.

Four, further examination, diagnosis and treatment process and treatment response

On November 23, 2022, the middle urine smear was used to find bacteria: moderate amount of G- bacilli, and continued ceftazidime and abamectin 2.5g q12h ivgtt for anti-infection and bladder irrigation.

On November 26, 2022, the bacterial drug sensitivity of the middle-stage urine culture (sampling on November 23) was CRKP, ≥ 100,000 /ml, and urine mNGS: a large number of Klebsiella pneumoniae (species strict sequence number: 406,866) was detected.

On November 29, 2022, the abdominal and pelvic CT was reexamined: bilateral dilated hydronephrosis accompanied with inflammatory changes of ureter, and the parenchyma of both kidneys was thin, and the inflammatory changes of cystitis might be larger, similar to that of 22-10-20 slices.

November 30, 2022 (sampling on November 29): Enterococcus faecalis was positive. On December 2, according to the drug sensitivity, fosfomycin 3g qod was added orally, and ceftazidime and abamectin were suspended.

Repeated urine cultures on March, April and June, December, 2022: Enterococcus faecalis was positive and CRKP was negative.

On December 8, 2022, the urine WBC was 38738/μ L, and the bacterial count was 43285/μ L; Urine culture: CRKP positive, Enterococcus faecalis negative.

Phage therapy was carried out from the afternoon of December August, 2022: Phage cocktail (composed of 5 strains of Klebsiella pneumoniae phages A103KP172, A106KP176, A121KP192, A49KP106 and A58KP118, 5mL each), injected with 225mL physiological saline (according to the estimated bladder volume), and the total volume was 250mL, and then the catheter was clamped.

Urine routine on the third day of phage treatment on December 11, 2022: white blood cell count: 235/uL, bacterial count: 722/uL；; Urine bacterial culture was negative.

Urine routine on the 5th day of phage therapy on December 13th, 2022: white blood cell count: 279/uL, bacterial count: 92/ul; Urine bacterial culture was negative; Blood WBC 6.35X109/L, N 70%, hs-CRP 0.9mg/L, ESR 26mm/H, and inflammatory index decreased compared with before; Re-examination of urinary color ultrasound showed that bilateral renal pelvis separation and upper ureteral dilatation were better than before (10-20), and the thickness of bladder wall was reduced (12-25mm→13mm).

He was discharged from hospital on December 14, 2022 for follow-up.

V. Final diagnosis and diagnosis basis

Final diagnosis:

Complex urinary tract infection (CRKP, Enterococcus faecalis)

Neurogenic bladder, hydronephrosis and hydroureter (indwelling catheter)

Renal insufficiency

Diagnostic basis:

The patient is a middle-aged and elderly male with neurogenic bladder caused by paraplegia, indwelling catheter, turbid urine with flocs, increased CRP and PCT, significantly increased WBC and bacterial count in urine, repeated CRKP positive in urine culture, positive in enterococcus faecalis, abdominal basin CT: hydronephrosis of renal pelvis and ureter, anti-infection, normal inflammatory markers and urine routine after phage treatment, clear urine and negative urine culture, so complicated urinary tract infection.

The patient suffered from anorexia and dysuria, and the serum creatinine increased obviously. Abdominal CT showed that both kidneys were enlarged, the cortex was thin, and bilateral urinary tract was hydronephrosis. After active treatment such as controlling infection and improving renal function, the serum creatinine decreased, so the diagnosis of renal insufficiency was clear.

Six, experience and experience

Phage is a targeted sterilization virus in nature and a sterilization star in the "pre-antibiotic era". Phage therapy has a history of more than 100 years, but the discovery and application of broad-spectrum antibiotics have gradually marginalized it. With the increasingly serious problem of bacterial drug resistance, phages have once again received attention and become the most promising supplement and alternative therapy for treating superbugs. The clinical application of phage in China is relatively late, but it has developed rapidly in recent years. In 2017, the Shanghai Institute of Phage and Drug Resistance was established, with Professor Hu Bijie as an academic member. Since 2018, the institute has carried out the first clinical trial of phage therapy in China. At present, it has treated nearly 100 patients with drug-resistant bacterial infections from all over the country and accumulated rich clinical experience in phage therapy, which is a leading position in the field of clinical phage therapy in China.

Phage has many advantages, such as host bacteria dependence, targeted specific sterilization, no infection to eukaryotic cells (little influence on normal flora), no influence on bacterial drug resistance, synergy with antibacterial drugs, penetration of biofilm and so on. The cure rate of acute bacterial infection is high, and the therapeutic effect of chronic bacterial infection is no less than that of antibacterial drugs, and the safety of phage treatment is also extremely high. A systematic retrospective study showed that the vast majority of patients who received phage therapy had no or only slight adverse reactions, 86.7% patients’ clinical symptoms improved, and 78.8% patients achieved the eradication of pathogenic bacteria. Our clinical trials also show that more than 70% of patients have achieved good therapeutic effects, and there are no obvious cases of adverse reactions. This patient was repeatedly infected with Klebsiella pneumoniae due to long-term paraplegia, abnormal urinary tract structure, indwelling catheter and other factors. The diagnosis of complicated urinary tract infection was unquestionable, and the choice of antibacterial drugs was limited due to multi-drug resistance and renal insufficiency. Phage therapy is very suitable.

The disadvantages of phage therapy include narrow host spectrum, individualized plan (it is difficult to treat empirically), no unified standard for the best treatment decision, and rapid tolerance. Phage cocktails, combined antibacterial drugs and multiple treatments are usually used in clinic to improve the curative effect. At present, the targeted pathogens of phage therapy in our team mainly include: multi-drug resistant Gram-negative bacteria (Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecalis); Covering respiratory system, urinary system, abdominal cavity, bones and joints, skin and soft tissue and other infected sites; Treatment depends on the site of infection, and intravenous application of phage is still being explored. In this case, the patient didn’t have percutaneous nephrostomy because of the little clinical benefit, so he was treated by transurethral bladder perfusion, and the phage could not cover the whole urinary tract evenly. Although the pathogen turned negative in a short period of time and was well tolerated, its long-term curative effect may not be good, and it needs repeated phage treatment.

Phage therapy has huge clinical demand and broad market. In recent years, our team has focused on the clinical application (treatment and prevention and control of nosocomial infection) and basic research of phage therapy, with a view to becoming a powerful weapon to curb drug-resistant bacteria in the future.

references

[1] Uyttebroek S, Chen B, Onsea J, Ruythooren F, Debaveye Y, Devolder D, Spriet I, Depypere M, Wagemans J, Lavigne R, Pirnay JP, Merabishvili M, De Munter P, Peetermans WE, Dupont L, Van Gerven L, Metsemakers WJ. Safety and efficacy of phage therapy in difficult-to-treat infections: a systematic review. Lancet Infect Dis. 2022 Aug; 22(8):e208-e220.

[2] Chegini Z, Khoshbayan A, Taati Moghadam M, Farahani I, Jazireian P, Shariati A. Bacteriophage therapy against Pseudomonas aeruginosa biofilms: a review. Ann Clin Microbiol Antimicrob. 2020 Sep 30; 19(1):45.

[3] Lusiak-Szelachowska M, Weber-Dabrowska B, Gorski A. Bacteriophages and Lysins in Biofilm Control[J]. Virol Sin, 2020,35(2):125-133.

Every Monday night

The Department of Infectious Diseases of Zhongshan Hospital affiliated to Fudan University in Shanghai will be with you!

Photo: Xiaoxiao

Original title: "Detective Case: The Nemesis of Super Bacteria is Coming"

Read the original text

On April 24, Shandong Province pressed the countdown switch for the candidates in the 2020 provincial examination, and Shandong Province made an announcement! As the first province to issue a provincial examination announcement, many students are concerned about what changes have taken place between this year’s provincial examination announcement and previous years. How to prepare as a test preparation party?

The teaching and research group of hornbill public examination made a professional interpretation of the announcement of Shandong provincial examination.

First, from the comparison of data in previous years, we can see the trend of this year’s provincial examination.

Compared with the data in recent years, the total number of applicants has risen sharply for the first time, increasing by 141% according to last year.

Among them, Jining, Linyi, Heze, Yantai and Jinan all recruited more than 600 students.

Weihai, Rizhao, Zibo, Jinan and Yantai increased by more than 3 times.

Among the recruitment regions or institutions in the province, there are 555 recruitment positions in Jining, with 785 people, accounting for 10.7%, ranking first.

Compared with previous years, the position of "high school and technical secondary school" was cancelled, and the minimum academic qualification limit was "junior college"

The five departments with the largest number of candidates come from four regions/institutions, and Yantai has two seats.

Second, in-depth interpretation of the provincial examination announcement, accurately positioning the preparation direction

First, highlight political standards.

Adhere to the guidance of the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era, implement the Party’s organizational line in the new era, adhere to the principle of party management of cadres, adhere to both ability and political integrity, and put morality first, and put political requirements throughout the whole recruitment process. The content of the exam focuses on the ability to solve problems under the guidance of the supreme leader Socialism with Chinese characteristics Thought in the new era; The inspection session focuses on understanding the candidates’ political beliefs, political positions, political awareness and political performance. By checking the source, we will ensure that the newly recruited civil servants have excellent political quality and good moral conduct.

Interpretation of teaching and research group of hornbill public examination;

The focus of this announcement falls onPhysical examination and investigationupper/better/previous/a surname, that is, in the preparation session.In the part of political review, the main investigation is the personal political position.

Therefore, if students want to enter the public service, they can’t have anything that goes against public order and good customs and ethics.

Second, the interview questions are professional and differentiated.

In-depth promotion of grading and classification examinations, distinguishing the different characteristics of institutions at or above the municipal level and below the county level, will separately order written examination questions for public subjects. According to the nature and characteristics of the work of public security, prisons and other organs, the civil service interview is organized and implemented by classification. In accordance with the requirements of building a high-quality professional civil servant team, we will increase the intensity of professional ability testing, and will conduct professional tests on candidates for 286 positions with strong professionalism to further improve the quality of candidates. Explore the difference investigation, highlight the suitability of people and posts, choose people by things, and avoid simply taking people by points.

Interpretation of teaching and research group of hornbill public examination;

The announcement of this year’s recruitment is inclined to specialization.

Posts with small language requirements require higher professional ability. Total score ratio = language 50%+ test 25%+ application 25%.

In law-related positions, the proportion of requirements for line testing has increased. Total score ratio = legal 30%+ test 40%+ application 30%.

Third, it tends to be grassroots experience and fresh graduates.

Except for some special positions, provincial authorities will mainly recruit people with more than 2 years of grassroots work experience; Organs below the county level will recruit 1021 civil servants specially for college graduates, encourage and guide outstanding college graduates to apply for grass-roots positions, and make contributions to the grass-roots front line. The province will recruit 115 civil servants to serve grassroots project personnel and retired soldiers of college graduates who have served in the military for more than 5 years. At the same time, 151 retired military personnel were recruited. The recruitment of grass-roots civil servants for local outstanding talents, such as secretaries of grass-roots party organizations and long-term township (street) staff, will be organized and carried out separately according to the actual situation.

Interpretation of teaching and research group of hornbill public examination;

This time, the inclination of the grass-roots units was announced.Bigger, whether it is the attention of grass-roots work experience or the tilt of one’s position to the grass-roots level. andProvide more jobs for fresh graduates, and the proportion of fresh graduates is 14.4%.

Fourth, solve the employment pressure and provide humanized recruitment.

In response to the impact of the epidemic, the online registration time has been extended to facilitate candidates to apply for the exam. At the same time, establish a registration tolerance mechanism. If you have not obtained the qualification certificate required by the recruitment position yet, you can register for the exam first after the applicant has made a commitment to provide the qualification certificate before the deadline for qualification examination; Failing to provide it before the deadline for qualification examination, the recruitment agency shall cancel the qualification for application or employment.

Expert interpretation:

aim atDue to the epidemic this year, many qualification examinations are delayed indefinitely, so if there is a qualification certificate requirement, this provincial examination will give you fault-tolerant time.

Fifth, the form and score of the interview have changed greatly.

The exam announcement pointed out thatInterviews take many forms, such as structured interviews.

Interpretation of teaching and research group of hornbill public examination;

The original text of last year’s announcement was that interviews were mainly structured interviews. What’s the difference between those two? One is the structured interview, then the others are supplemented. This was last year, and this year, we were told directly that structured interviews and other forms were adopted.

In the past, the national examination was mainly structured interviews, and there were few others. Now, structured interviews, structured group interviews, and interviews without leading groups are basically equal, so the national examination is a weather vane.

We can predict that other provinces will also keep up with the diversified examination forms of interviews.

Last year, our written test and interview still accounted for 50% of the provincial exams in Shandong Province. This year, the written test only accounted for 40%, and the interview accounted for 60%. The proportion of the exam tilted towards the interview.

The number of candidates in Shandong province is the largest in previous years, and it is also known as the small country exam. Candidates who prepare for the exam can adjust their preparation strategies from the direction of announcement interpretation. Finally, I wish all candidates can get to be no.1 and get good grades in the provincial exams!

　　At the 2022 Global Industrial Internet Conference held in Shenyang, the staff of the participating enterprises demonstrated the industrial Internet platform for garment customization. Xinhua News Agency reporter Wang Yijie photo

　　Visitors visited the exhibition hall of "2022 China 5G+ Industrial Internet" held in Wuhan. Xinhua News Agency reporter Cheng Minshe

　　According to the latest data from the Ministry of Industry and Information Technology, the scale of China’s industrial Internet industry is expected to reach 1.2 trillion yuan in 2022, providing strong support for high-quality economic and social development. The reporter learned from many aspects that China will further improve the top-level design, make full use of fiscal and taxation policies, promote enterprises to actively use 5G and other technologies to carry out digital transformation of factories, accelerate the scale development of industrial Internet, promote the deep integration of digital economy and real economy, and continuously release the power of industrial upgrading.

　　Empowering the transformation and upgrading of traditional industries

　　As a key path to promote the deep integration of the digital economy and the real economy, the industrial Internet continues to release effects in promoting the transformation and upgrading of traditional industries.

　　Industrial Internet logo analysis system is the foundation of industrial Internet network system and an important link to support industrial Internet. In 2022, China’s industrial Internet logo analysis system was fully completed.

　　Zhao Zhiguo, director of the Information and Communication Administration Bureau of the Ministry of Industry and Information Technology, said that at present, all the top-level nodes and two disaster recovery nodes in the five countries in the east, west, north and south are online, and the second-level nodes have achieved full coverage, serving nearly 240,000 enterprises, and cultivating more than 240 influential industrial Internet platforms, including 28 cross-industry and cross-domain platforms, which have effectively promoted data interoperability and resource coordination in the whole product process, production links and upstream and downstream of the supply chain, and accelerated the digital transformation of enterprises.

　　From the perspective of the transformation of the empowerment industry, China has built a number of application promotion service carriers for the common needs of the industry, cultivated "low-cost, lightweight" solutions, and lowered the threshold for digital transformation of enterprises, especially small and medium-sized enterprises.

　　"We focus on the characteristics of various industries, formulate and promote industrial Internet convergence application guidelines for more than 10 key industries, such as steel and electronics, and guide industrial enterprises to develop industrial Internet applications according to their respective industries and enterprises. We implemented the industrial Internet innovation and development project, accelerated the research and industrialization of key technology products, and issued a number of national standards, industry standards and group standards to further improve the standard system. " Zhao Zhiguo said.

　　It is worth mentioning that in the construction and application of "5G+ Industrial Internet", China has built more than 4,000 "5G+ Industrial Internet" projects in more than 10 key industries such as automobiles and mining, and accelerated the popularization of 20 typical application scenarios such as collaborative R&D design and remote equipment control, which effectively promoted enterprises to improve quality, reduce costs and increase efficiency.

　　Zhao Zhiguo introduced that industrial 5G converged products are increasingly abundant, and the price of modules is 80% lower than that in the initial stage of commercialization. All localities have set off a boom in the construction of 5G fully connected factories, accelerating the further deepening and expansion of 5G to the core control link of production.

　　Combined measures to accelerate large-scale development

　　In the eyes of the industry, China’s industrial Internet development is in a critical period of initial exploration and scale development, but it still faces challenges to improve the coverage and application depth of industrial Internet.

　　Zhao Gang, president of Saizhi Industrial Research Institute, believes that in terms of platform applicability, there are many types of industrial enterprises and complex technological processes, and how to adapt the general industrial Internet platform to the application needs of different enterprises needs further exploration. In terms of system application, the production equipment of industrial enterprises may come from different manufacturers, the interface standards of equipment are not uniform, and some systems are still relatively closed, which puts forward higher requirements for system integration. In terms of construction cost, the construction of industrial internet involves the procurement and deployment of sensors, communication modules and network equipment, and industrial enterprises, especially small and medium-sized enterprises, are facing problems such as "lack of technology, lack of talents and lack of funds".

　　The reporter noted that in this regard, relevant departments will make efforts from the aspects of excellent environment, innovation and strong application to accelerate the large-scale development of industrial Internet.

　　Zhao Zhiguo said that the Ministry of Industry and Information Technology will study and formulate policies and measures to promote the large-scale development of industrial Internet, further improve the top-level design, make full use of fiscal and taxation policies, strengthen the integration of production and education, and further create a good development environment. Strengthen technological innovation, implement the industrial Internet innovation and development project in depth, improve the standard system, and crack the key shortcomings that restrict large-scale development; Deepen industrial innovation, support telecom enterprises, Internet platform enterprises, industrial enterprises and other market players to give full play to their respective advantages, strengthen linkage and coordination, vigorously cultivate leading industrial Internet enterprises and "specialized and innovative" small and medium-sized enterprises, and create a healthy and sustainable industrial ecology.

　　At the same time, the popularization of industrial Internet will be further accelerated. Zhao Zhiguo said that it will speed up the cultivation of advanced factories, promote enterprises to actively use technologies such as 5G to carry out digital transformation of factories, and promote the wide application of new technologies, new scenes and new models. Accelerate the upgrading of industrial clusters, carry out the "Hundred Cities and Thousand Parks" activity of industrial Internet, summarize and promote successful cases, and promote the digital and green development of industrial parks. Deepen the expansion of key industries, extensively carry out the docking of supply and demand, and strengthen the popularization of industrial Internet in key industrial chains.

　　Continue to promote the upgrading of industrial Internet files.

　　The industry believes that in the next step, it is necessary to combine the needs of digital transformation of the industry, focus on professional deep cultivation, cross-border financing and cooperation, strengthen technological innovation and network security, and promote the upgrading of industrial Internet to provide support for digital transformation.

　　Yu Xiaohui, president of China Information and Communication Research Institute, said that it is necessary to further support enterprises to deepen their professional capabilities and build an internationally competitive industrial Internet platform. Encourage platform enterprises to make full use of the vast advantages of China’s market, enrich their own digital, modular and platform-based manufacturing resources in service enterprises, incubate professional industrial apps, and develop large-scale promotion applications. Give play to the guiding role of financial funds, incite more social capital to invest in platform industries, support platform enterprises to make rational use of financing funds, realize the accumulation of core technologies through mergers and acquisitions, joint ventures, etc., and promote the cross-industry, cross-field and cross-regional deepening application and promotion of advantageous platforms.

　　In terms of continuously strengthening technological innovation, Yu Xiaohui suggested, on the one hand, focusing on promoting the development and application iteration of industrial mechanism models and improving the basic technical support level of industrial Internet platforms. On the other hand, relying on the network of innovation centers, we will accelerate the incubation of original technologies, carry out innovation incubation around digital twinning, real-time simulation and edge intelligence, and accelerate the sharing and utilization of platform innovation resources nationwide.

　　Zhao Gang said that the next step is to deepen the research and development of customized templates for industrial Internet in different industries, and develop industrial Internet solutions that meet the characteristics of different industries such as machinery, electronics, automobiles, materials and equipment to meet the common needs of industrial enterprises; Second, it is necessary to strengthen the standardization of industrial Internet and realize the integration and data sharing of different devices and systems; Third, it is necessary to strengthen the construction of industrial Internet security system to ensure the network and data security of enterprises.

Topic: Welcome to The 17th National Congress of the Communist Party of China

　　Rooting in fertile soil and working hard ―― Modern distance education for cadres in rural party member has been carried out in depth.

　　

　　　　On April 28th, the National Conference on Modern Distance Education for Rural party member Cadres was held in Beijing. Member the Political Bureau of the Communist Party of China (CPC) Central Committee, Secretary of the Secretariat of the Central Committee, Minister of the Organization Department of the Central Committee, and He Guoqiang, leader of the National Leading Coordination Group for Modern Distance Education for Cadres in Rural party member, attended the meeting and delivered a speech. Xinhua News Agency reporter Gao Jieshe

　　　　Xinhuanet Beijing, September 30th (Reporter Li Yajie) Zhang Xueying, a farmer from Zhengchang Village, Tunzi Town, Xunxian County, Henan Province, used the modern distance education information service station in the village to post her own stone carving works online. In June this year, a scenic spot in Jidong County, Heilongjiang Province signed a stone carving work with her with a total value of more than 4 million yuan, equivalent to four times the amount of orders she received in the past year. She boasted to everyone: "Distance education really helped me a lot."

　　　　In view of the fact that being a pilot in the central region is more important than rural areas and the task of developing distance education is heavy, Henan actively explores new ways to develop modern distance education in line with local conditions. At present, more than 47,000 terminal receiving stations have been built and opened, which are vividly called "through train" to publicize the Party’s principles and policies, "booster" to improve the quality of cadres in rural party member, and "heart-to-heart bridge" to close the relationship between the party and the masses.

　　　　Since the development of modern distance education for cadres in rural party member, cadres and masses in rural party member have been able to hear the voice of the CPC Central Committee and learn the relevant principles and policies of the central government without leaving the village, which has narrowed the distance between the central government and the rural grassroots and promoted the smooth implementation of the Party’s principles and policies in rural areas to thousands of households. At the same time, the cadres and the masses in rural party member obtained information, changed their ideas, developed production, and achieved great economic benefits, which provided strong support for the construction of new socialist countryside.

　　Pilot first scientific planning and classified implementation

　　　　At the beginning of 2003, in order to conscientiously implement the spirit of the 16th National Congress of the Communist Party of China, and actively explore effective ways for rural party member cadres to receive regular education and benefit farmers for a long time, the central government decided to start the pilot project of modern distance education for rural party member cadres in Shandong in the east, Hunan in the middle, Guizhou in the west and Jinzhai County in Anhui Province.

　　　　At the beginning of 2005, the pilot areas were expanded to nine provinces and regions, including Shanxi, Liaoning, Jilin, Heilongjiang, Jiangsu, Zhejiang, Henan, Sichuan and Xinjiang. By the end of 2006, the whole pilot project was basically completed. After nearly four years of pilot work, more than 200,000 terminal sites have been built, nearly 40,000 teaching materials and courseware have been integrated and developed, and a backbone team of 300,000 people has been established, with more than 200 million rural party member cadres and farmers receiving education and training.

　　　　Through modern distance education, the cadres and the masses in rural party member in the pilot areas have improved their comprehensive quality, enhanced their ability to start a business and become rich, and further strengthened the relationship between the party and the masses.

　　　　With the approval of the Central Committee, the National Conference on Modern Distance Education for party member Cadres in Rural Areas, held on April 28th this year, made a comprehensive arrangement for developing modern distance education for party member cadres in rural areas throughout the country. On July 4th, the General Office of the Central Committee of the CPC issued "Opinions on Developing Modern Distance Education for party member Cadres in Rural Areas of China". The central government’s overall arrangement for the modern distance education of rural party member cadres is: from the second half of 2007 to the end of 2010, it will take three to four years to basically build a modern distance education network system for rural party member cadres throughout the country, complete the task of infrastructure construction, and basically achieve full coverage of sites in towns and villages.

　　　　According to this overall goal and local conditions, all localities have promoted various constructions step by step. The three provinces that were piloted in advance further consolidated and improved the management and use level of the established sites. Shandong decided to establish a centralized study day system for cadres in rural party member in an all-round way, and started the implementation of the "party member cadres’ modern distance education project to get rich through science and technology"; Hunan carried out the model of distance teaching and the selection of "Yuan Longping Science and Technology Award" to promote the in-depth development of learning and application; Guizhou has made great efforts to build a number of excellent demonstration sites of "village-school combination" and continuously improve the level of distance education in the province.

　　　　Nine provinces and autonomous regions that have expanded the pilot project will speed up the construction progress on the existing basis, realize full site coverage in towns and villages by the end of 2008, and carry out work in improving the mechanism, strengthening management and deep chemical utilization. In accordance with the principle of "integrating resources, co-constructing and sharing", Henan has further explored the methods of joint construction of infrastructure, joint investment of human resources, joint production of teaching materials and courseware, and joint efforts of education and training to further promote modern distance education.

　　　　According to reports, the 19 provinces, autonomous regions and municipalities and Xinjiang Production and Construction Corps that have started this work will complete the task of infrastructure construction by the end of 2010 and achieve full coverage of sites in towns and villages. The eastern region will appropriately accelerate the pace of construction, and the central and western regions will steadily promote various constructions according to actual conditions.

　　Learning policy broadens one’s horizons and leads to wealth.

　　　　"Hello,’ Director Shi’? My family’s Kaite apricot is going to go to the greenhouse. Is there a program on this?" Early in the morning, Shi Chengguan, a distance education administrator in Shijia Village, Pingyi County, Shandong Province, received a phone call from the villager Chu Yongcai. "As it happens, the distance education program has just downloaded the greenhouse cultivation technology of Kaite apricot, and it will be broadcast until 10 o’clock for you. What do you think?"

　　　　In the summer of 2004, a reception site for modern distance education for rural party member cadres was built in Shijia Village, and the rich and colorful content of distance education programs became the "golden key" for villagers to get rich. When the administrator becomes an official, he insists on downloading distance education programs every day and organizing party member people to study and watch them at least once a week. In order to meet the individual needs of farmers, the village invested in new professional equipment, laid cables and delivered distance education programs to every household, which was affectionately called "Distance Education TV Station" by farmers. In order to enrich the content of the program, the village also purchased more than 3,000 educational CDs as auxiliary teaching materials. After the opening of "Distance Education TV Station", it was warmly welcomed by the peasants. Anyone who wants to watch any program can just call the administrator.

　　　　Since the opening of the "Distance Education TV Station" in Shijia Village for three years, it has brought benefits to the peasants in the village, and the feelings between cadres and the masses have also drawn closer. Shi Chengxue, who has been the secretary of the village party branch for many years, said with emotion: "It is distance education that has brought me a panacea and taught me how to be a good village cadre!"

　　　　Around the central government’s major decision-making, major activities and key work, all localities have organized the production of learning materials for the key, difficult and hot issues concerned by rural party member cadres and farmers, and timely carried out special education and training to give full play to the role of modern distance education for rural party member cadres.

　　　　In the activities of advanced education, grass-roots party organizations around the country use modern distance education to organize party member to study, which enhances the attraction and improves the participation rate. In the process of promoting the construction of new socialist countryside, modern distance education network system has been used in various places to publicize and educate the policies, measures and experiences of the rural party member cadres and farmers, which has increased the talents of rural cadres and party member and trained a group of new farmers who are literate, know technology and can operate.

　　　　In view of the fact that local farmers lack ideas and methods to get rich, Ningbo City, Zhejiang Province produced "Thirty-six Strategies for Rich Villages", which was very popular after broadcast. The Party branch of Alashan Village, xinyuan county, Xinjiang, organized local herdsmen to watch the technical training materials of "Mujiale" tourism and catering service at the receiving site, which solved their problems of ideological emancipation and technical training difficulties and promoted the development of tourism. In 2006, there were 20 "Mujiale" in this village, and the monthly net income of each family reached more than 5,000 yuan in the golden season of tourism.

　　　　In order to welcome the victory of the 17th National Congress of the Communist Party of China, various localities have also produced a number of special propaganda films that are loved by cadres and the masses in rural party member.

　　　　Shandong organized and produced a set of special talk shows, which were used as the necessary teaching materials for the intensive study in rural party member. Jilin organized and produced a special program "Representative Style" to focus on publicizing the representatives of the 17th CPC National Congress from the grassroots. Xinjiang used "Xinjiang Kunlun Net" to broadcast "Song of Communist party member" to create a good atmosphere for the victory of the 17th CPC National Congress.

Editor: Li Xingchi

　　Moderator Shui Junyi:

　　Good evening, everyone. Welcome to Global Sight, which is being broadcast live on the news channel. I’m Shui Junyi. Russian President Vladimir Putin published an article in The New York Times, which mercilessly attacked the US government, which caused an uproar among American media and politicians. The heavyweight Senator Menendez publicly said that he almost wanted to vomit after reading Putin’s article. The White House also made a fierce counterattack. What did Putin write to make Americans so angry? In addition, Syrian President Bashar al-Assad recently said in an interview with RIA Novosti that Obama must promise not to arm the opposition, otherwise he will not hand over chemical weapons. What does such a tough stance mean? Will it be the reason for the United States to attack it again? Today, our studio invited special commentators, Mr. Yin Zhuo and Mr. Song Xiaojun, to participate in our discussion. First of all, let’s take a short film to learn the details.

　　Commentary:

　　The dramatic situation in Syria has made progress again after Obama announced his request to Congress to postpone the vote on the military strike against Syria. On the 12th, the Syrian government submitted relevant documents to the United Nations on its accession to the Chemical Weapons Convention. The United Nations said that this means that Syria has officially started the process of accession to the Chemical Weapons Convention. On the same day, the Permanent Representative of Syria to the United Nations, Jaafari, said that in a legal sense, Syria has become a member of the Convention.

　　On the same day, the Russian media broadcast an interview with Syrian President Bashar al-Assad.

　　President Bashar al-Assad of Syria:

　　I want to reiterate that without Russia’s proposal, we would not discuss the transfer of chemical weapons with any country, saying that Syria was threatened to give up chemical weapons, which is a propaganda means of the United States, because Kerry and Obama always want to show the United States as a winner who achieved their goals through threats.

　　Commentary:

　　At the same time, in the interview, Assad once again denied that the Syrian government used chemical weapons. He said that the chemical weapons attack on the outskirts of Damascus on the 21 ST of last month was caused by terrorists to provoke the United States to use force against Syria. They have chemical weapons provided by foreign countries, and Syrian government forces have never used chemical weapons. In recent days, Obama’s plan to attack Syria militarily is under siege, and Russia’s plan of exchanging chemical weapons for peace has received more and more international support. Since Obama announced the postponement of the plan, the chemical weapons crisis in Syria seems to have begun to develop in a good direction. However, the game between the United States and Russia on the situation in Syria is still going on.

　　On the 12th, a long letter to the American people and political leaders was published in the The New York Times that day, and the author was Russian President Vladimir Putin. In the article, Putin warned the United States that "military strikes against Syria will only bring chaos and casualties." And pointed out that "many countries no longer regard the United States as a model of democracy, but only know how to play rough." For this article, the British "Guardian" said that while Putin extended a hand of friendship and cooperation to Obama, he repeatedly stabbed Obama’s wound with a knife. Just a few hours after Putin’s article was published, US Secretary of State Kerry flew to Geneva, Switzerland, and held talks with Russian Foreign Minister Lavrov on the Syrian chemical weapons for peace plan. The New York Times commented on the dramatic changes in the Syrian situation. Just as Obama hesitated, Putin stood in the center of the stage. However, some commentators believe that even if the proposal of exchanging chemical weapons for peace becomes a reality, it will still face many political and operational difficulties in real implementation. However, there are still variables whether the United States, Russia and Syria can reach a preliminary plan for the solution of chemical weapons. At that time, will the United States still put a military strike plan on the table, and how will the situation in Syria develop? Still worthy of attention.

　　Moderator:

　　There was a sentence in the second half of the short film just now, which I think left a deep impression on me, saying that Putin stood in the center of the stage just as Obama hesitated. Before the next conversation today, there is a very popular video from Russia today. Please watch it together. As we all know, the most popular column in the world, including China, is called "The Voice of China". Not long ago, it was said that Putin also made a good voice in Russia, and not only did he make a good voice in Russia, but he also won the turn of three tutors. This was the scene at that time, and the picture quality was average.

　　Let’s look at this picture and ask for advice. This is Putin’s side. In addition, of course, we have seen that Putin has many other sides, but it really surprised many people, including many Americans. Putin still has such a skill, that is, he wrote a commentary in the The New York Times, a best-selling newspaper in the United States and the western world, which suddenly caused such an uproar. What do you think of Mr. Yin?

　　Yin Zhuo Special Commentator:

　　I think Putin wants to light another fire, give Obama another push and push him down when public opinion, especially domestic public opinion, is unfavorable to Obama.

　　Moderator:

　　What do you mean?

　　Expert opinion: Putin "lights a fire" on Obama’s unfavorable public opinion.

　　Yin Zhuo:

　　Because we know that Obama decided to go to war this time, he had already crossed the red line, and now Bashar al-Assad’s regime has crossed the red line and decided to use force, and he has made a lot of hard words, whether your parliament agrees or not, I will use force, I have the right to use force, and so on. Now the domestic public opinion and the public opinion of the whole parliament are unfavorable to him. He feels that the number of votes is unfavorable to him and the possibility of passing it in the parliament is very small. Moreover, public opinion is widespread, and more than 60% of Americans oppose the use of force against Syria.

　　Moderator:

　　It is basically impossible to get such support in parliament.

　　Yin Zhuo:

　　In mainstream public opinion, in opinion polls, there is no such support. And Putin now, it turns out that he wants to stand on the moral high ground against Russia, that is, you used weapons of mass destruction as an excuse to use force against Syria. Of course, he is standing on the moral high ground, because big countries kill weapons, which is prohibited by international law.

　　Moderator:

　　The whole world opposes it.

　　Commenting: Putin severely criticized the abuse of power by the United States

　　Yin Zhuo:

　　But also killed many women, especially children, and children suffered a lot of casualties, so he stood on the moral high ground. On the other hand, now he has stood morally low, Putin has stood high, and Putin has clicked on this article again. You won the Nobel Prize, but you had better fight. You are a militant. At this time, Putin has become the commanding height of morality, but he is a militant. Put aside the use of chemical weapons, because Putin took it out because of the drastic measures. Bashar handed over the whole chemical weapons. Is it possible for you to use force? Now Putin stands on the moral high ground and asks him to promise not to use force. The United States will never promise. It is precisely because of such a contrast that he lost his moral points.

　　Moderator:

　　Let’s take a look at what Putin wrote on the The New York Times. In one passage, he said, "I doubt that many people all over the world now feel more and more that the United States is not a model of democracy, but only resorts to brutal force and forms gangs under the slogan of being either friends or enemies." In addition, he said that no matter how clear the target is and how sophisticated the weapons are, it is impossible to avoid civilian casualties, including the elderly and children, those who wanted to protect through action. "

　　In fact, he also said a passage, which we didn’t extract. He said that the United States should not always feel unique or different from the rest of society. You are actually a member of the international family. Therefore, in addition to some politicians in the United States, including the White House, who will immediately fight back later, many commentators say that Putin is very reliable. You see, he helped me in a difficult situation; Some people say that this year’s Nobel Peace Prize belongs to Putin. What does Mr. Song think? The so-called Putin gave Obama a hand at a critical moment, and now he is standing on such a commanding height to teach a lesson. Americans say not to think that Americans are unique in the world?

　　Expert opinion: Putin not only gave "steps" but also "helped them down"

　　Song Xiaojun Special Commentator:

　　Putin not only helped Obama, but also gave him a step and helped him. Therefore, in this case, it was Obama who was riding a tiger. The United States conducted a Gallup survey in the same period. The wars fought in the past 22 years, the Gulf War and the Iraq War, including Kosovo, were many times, including opinion polls. This time it was the lowest, 36%, like 82% when it was fought in Afghanistan, that is, in 2001, after the "September 11" incident, when it was fought in Iraq. But this time it’s 36%, and it’s still falling. How do you think Putin can get down this step? People give you a step to help you, what should they get? What I got was the good voice we talked about just now, and why he showed such an image this time, and even wrote this article in The New York Times, which shows that Putin is now facing internal problems in Russia, because local elections are about to be held in Russia. Moreover, Russia’s economic situation is not good now.

　　I saw the BRICS in the previous G20. In our BRICS countries, no one can do it except China, and the Russian people’s support rate for the United Russia Party is now declining. At this time, Putin has to use his personal charm to unite the Russian Party on the international stage, or win back the votes of his team in local elections, so he wants this.

　　Moderator:

　　But in any case, Obama is good, and his team seems to feel that Putin’s popularity is a bit overwhelming. Don’t forget Obama’s team. Some people say that they have always wanted to build Obama according to a star. Now there is a response to Putin’s high praise. Let’s listen to what he said.

　　Carney White House spokesman:

　　Unlike Russia, the United States represents the value of democracy and human rights in our own country and around the world. We believe that when children will not be killed by a dictator with poison gas, the global security level will also be improved.

　　Now 34 countries have claimed that the Assad regime was responsible for the use of chemical weapons that night.

　　I think it is also necessary to point out that it is a great irony to publish such a column, because it reflects the truly outstanding tradition of freedom of speech in this country, which is not shared by Russia. In the past few years, freedom of speech has greatly declined in Russia.

　　Commenting: The White House retorted and the war of words escalated.

　　Moderator:

　　Regardless of everything else, Carney typed it right away. There is no freedom of public opinion in Russia. Look, your president has to publish a commentary in my newspaper. But a very simple question may also be a hypothetical one, Mr. Yin, because we know that many things in Nobel are manipulated by Americans, and Americans will let Putin, if someone really nominates Putin for this year’s Nobel Peace Prize, is it possible? Is there a play?

　　Yin Zhuo:

　　Impossible, absolutely impossible.

　　Moderator:

　　Why?

　　Expert opinion: the United States will not give Putin the title of "peacemaker"

　　Yin Zhuo:

　　Because the Nobel Peace Prize has a very strong political ideology, its political ideology is on the side of the United States. Since it awarded the Nobel Peace Prize to Obama, it shows that people like Putin can never win the prize here, otherwise Putin will stand up against his own country’s system, so he wants to win the Nobel Prize. From here, we can see that from the White House spokesman, the leader of his parliament said that he was disgusting, and so on, we can see that Americans will never give Putin the title of peacemaker and let him win the Nobel Peace Prize. There is no possibility, and he will take various measures. Because now the initiative is not in Putin’s hands, the initiative is in Obama’s hands, and it is Obama, not Putin, who has the final say. Putin can only beat around the bush and say that you don’t want to fight. He can only persuade Obama not to fight, or exert pressure to really decide whether to fight or not. Who will win the Nobel Peace Prize in the end? Who will guide the outcome of the Syrian war? It is the Americans who have the final say, not the Russians, which can be judged.

　　Commenting: The fate of the Syrian government is decided in the ongoing negotiations on chemical weapons.

　　Moderator:

　　Another topic, let’s pay attention to Mr. Song. Today, the foreign ministers of the United States and Russia held a meeting in Geneva, which will be held in the next two days. It is said that the information leaked is not bad and promising. At the same time, however, Syrian President Bashar al-Assad had a saying that he accepted RIA Novosti and said very strongly that if you armed the opposition, I’m sorry, but I may not do anything about the transfer of chemical weapons. What does this sentence mean?

　　Song Xiaojun:

　　I think he is warning the United States and Israel not to push their luck. Putin handed you the steps, helped you down the steps, and I swept the ground under the steps. As a result, you have to give offensive weapons to the opposition, that is, the Syrian Free Army. Now it is the worst army to be beaten. It is not kind to do so, so it should be said. But in fact, Kerry and Lavrov must be laughing secretly, because everyone knows that this matter is very long. For example, in 2004, Gaddafi handed over chemical weapons, and Gaddafi’s chemical weapons were much less than those in Syria.

　　Expert opinion: Kerry and Lavrov "stole the fun" before the talks.

　　By 2011, when he was killed and shot down, his chemical weapon mustard gas was treated by 40%, and the chemical weapon raw materials were treated by 50%. This is a very long matter, and basically this matter is gone. In this case, the United States also knows that this matter is a face matter, which is Putin’s face and Obama’s face. As for whether this 1,000-ton chemical weapon can be disposed of quickly, everyone will forget it in the future. As soon as the heat of the two news cycles is over, everyone will ignore it. Other things, elections and other things. But it is a bit unkind to give weapons to the opposition at this time.

　　Moderator:

　　Of course, from Assad’s point of view, he must protect his own regime, but as you said, I am afraid that all parties, whether the United States and Russia or the US Congress, are a little snickered, which finally gives everyone a sigh of relief. Ok, our Global Sight will continue later.

Jellyfish Network, August 7th (YMG All Media Reporter, Liu Jie, Correspondent, Ma Shuangjun, Zhu Benxi, Zhao Qingyin) Yesterday at 9 am, accompanied by three sonorous and powerful drums, the first batch of transportation teams loaded with Buick Envision S and Envision S Ivia departed from SAIC-GM Dongyue Base and went to Buick dealerships across the country. This highly anticipated fashion sports medium-sized SUV will be delivered to the market one after another.

This is another shining moment for the brand after the Buick Envision S and Envision S Ivia rolled off the production line in batches a few days ago. "In recent years, SAIC-GM Dongyue Base has followed the trend of automobile consumption upgrading and industrial upgrading. Guided by’electrification, networking, intelligence and sharing ‘, and based on excellent manufacturing, it has continuously improved its manufacturing level. It has become the first factory in the world to pass BIQ L4 and the’Most Valuable Factory’, and has been awarded the honorary title of J.D. Power 2020 Platinum Factory." Pan Jiebo, general manager of SAIC-GM Dongyue Base, said that the newly launched Envision S and Envision S Aivia have inherited Envision’s excellent quality genes and will bring consumers a better driving experience with their excellent product strength, injecting new vitality into the high-quality development of SAIC-GM and Dongyue Base, and will also bring new opportunities for the upgrading of the automotive industry in Yantai Development Zone and the conversion of old and new kinetic energy.

The automobile industry is one of the three billion-dollar industries in the development zone, and it is also a traditional advantageous industry in Yantai. As the leader of the city’s automobile industry, SAIC-GM Dongyue Base has driven the vigorous development of upstream and downstream industries and related enterprises, and has become an important support for the city’s high-quality development. The shipment of the Buick Envision S and Envision S Aivia is another masterpiece of SAIC-GM Dongyue Base to promote industrial upgrading and accelerate the conversion of kinetic energy. "The launch of the upgraded models of the Envision S and Aivia series will surely lead the new wave of iterative upgrading of sports models and luxury models, and further enhance the brand influence and market competitiveness of Buick series cars." Liu Jianmin, deputy secretary of the Yantai Development Zone Working Committee and deputy director of the Management Committee, is full of expectations for the prospect of this new model, and hopes that Dongyue Base will take this opportunity to take advantage of the trend, take advantage of the trend, hedge the impact of the epidemic with innovative development, and lead the future on the road of high-quality development.

As an important model produced by Dongyue, since its launch in 2014, Buick Envision has produced and sold 1.10 million vehicles, exported to high-end markets such as North America, and exported 150,000 vehicles in recent years. "As the latest member of the Buick SUV family, Buick Envision S is of extraordinary significance to the Buick brand. It is not only the latest global strategic model developed by the Buick brand with global superior resources, but also has the all-round strength of trendy and dynamic aesthetics, all-round driving control, ecological interconnection, global safety, and full sense of comfort, bringing a unique luxury SUV driving experience to the new generation of consumers. At the same time, it shows Buick’s deep accumulation in SUV product development and the rapid pace of technological update iteration, enriching and refreshing the Buick SUV lineup and strength. It will join hands with Buick Envision to achieve a stronger layout in the mid-range SUV market segment. "Niu Feng, Chief Sales Officer of Buick Marketing Division of SAIC General Motors Sales Co., Ltd., introduced that with the sales of Buick Envision S and Envision S Ivia, the Buick SUV family lineup will be further expanded. The new car will join Envision, Envision, Encore GX and Encore to consolidate the competitive strength of the Buick brand in the SUV market and meet the diverse needs of the new generation of consumers with a richer model portfolio. At the same time, the listing of Envision S and Envision S Ivia also shows Buick’s deep accumulation in SUV product development and the rapid pace of technological update and iteration, accumulating new momentum and releasing new vitality for the Buick brand on the road of "smart travel".

From the development and growth history of the Buick Envision model, we can also see the growth history of SAIC-GM’s Dongyue base focusing on high-end and moving towards a first-class automobile manufacturing base.

From the first Sail off the production line to fill the gap in the car industry in Shandong Province, SAIC General Motors Dongyue Base now has four vehicle production processes of stamping, body, paint, and final assembly and powertrain workshops such as engines and gearboxes. The products cover Buick Envision, Envision S, Envision GX, Excelle and Chevrolet Chuangjie, Volando, Kovoz and other series models, as well as S-tec, Ecotec series engines and S6, CVT series gearboxes. A total of 5.50 million vehicles, 15.60 million powertrains, and an output value of more than 570 billion yuan have been produced, driving 108 first-class suppliers to build factories in Shandong (78 in Yantai). Under this leadership, Yantai automobile industry production enterprises reached more than 410, of which, there are more than 200 local enterprises for SAIC GM Dongyue base supporting, including engine, transmission, fuel injection, steering, brake disc, tire, interior and exterior decoration and automotive electronics and other key parts production enterprises, the local matching rate of more than 80%, a Dongyue base as the core of the 100 billion Yuan level automobile and parts industry cluster spectacular.

As a leading enterprise in the city’s automotive industry, SAIC-GM Dongyue Base has always been exploring and leading. In the past two years, SAIC-GM Dongyue Base has aimed at "safety, green and wisdom" and continuously promoted the transformation and upgrading of the industrial chain and supply chain. Launched the first CVT stepless transmission products, using GM’s world’s first leaner double-layer plant design, the first time to realize the unmanned and intelligent environmental protection technology of the internal material conveying system, to create an industry intelligent manufacturing demonstration factory; invested 200 million to implement water-based paint transformation projects, invested 100 million yuan to build VOC exhaust gas combustion system, innovatively implemented energy-saving and emission reduction technologies such as circulating air reuse, intelligent opening of pump stations, transmission oil mist recovery, and silane process improvement, which has driven the development mode of the entire industrial chain and the conversion of old and new kinetic energy.

Welcome to Autohome Foshan Promotion Channel, we bring you a worthy car purchase benefit – currently in-depth promotions. In Foshan area, buyers of Blue Electric E5 can enjoy a cash discount of up to 40,100 yuan, making the minimum starting price of this model only 99,800 yuan. This is a car purchase opportunity not to be missed. Want to seize this affordable car purchase opportunity? Please click "Chatty Car Price" in the quotation form below to get the latest promotion details and strive for higher discounts, hurry up and act!

With its well-designed body size, the Blue Electric E5 has a 4760mm*1865mm*1710mm ratio of length, width and height, giving it an elegant and dynamic body posture. The 2785mm wheelbase and the front and rear wheelbases are 1585mm and 1580mm respectively, ensuring driving stability and comfort of the interior space. The tire size is 225/55 R18, and the front and rear tire specifications are consistent, which not only improves the driving grip, but also gives the vehicle a unique wheel style, further enhancing the overall visual effect.

The interior design of the Blue Electric E5 is dominated by simplicity and technology, using high-quality leather materials to create a steering wheel, providing a good grip and touch. The 12.3-inch central control screen occupies the visual focus of the car, integrating multimedia systems, navigation, telephone, air conditioning and sunroof control, making it convenient and intuitive to operate. In terms of seats, imitation leather materials are used, and the main and passenger seats support front and rear adjustment, backrest adjustment and high and low adjustment to ensure passenger comfort. The second row of seats also supports backrest adjustment, while the rear seats support proportional reclining, providing flexibility for loading space. The overall interior design is both practical and delicate, fully demonstrating the humanized consideration of the Blue Electric E5.

The Blue Electric E5 is equipped with a 1.5L L4 engine with a maximum power of 81 kilowatts, providing a continuous power output for the vehicle. The maximum torque of this engine is 135 Nm, and the E-CVT continuously variable transmission ensures the ride and fuel economy of the vehicle.

Summarizing Autohome owners’ comments on the Blue Electric E5, he praised the balance and stylish sense of the vehicle’s exterior design, believing that its atmosphere is stable and not exaggerated, especially the green body, which reveals a high-end and casual atmosphere, especially favored by young drivers. This exterior design undoubtedly provides owners with a unique personality expression and comfortable driving experience.

Speaking of pickup truck models, I believe most people will think of Ford F-150 (parameter picture), while domestic pickup trucks are mostly positioned as agricultural vehicles. Until the appearance of the Great Wall Cannon, everyone changed the impression that domestic pickup trucks are low-end and simple. Recently, we have obtained a set of spy photos of the interior of the off-road version of the Great Wall Gun from relevant channels. Compared with the ordinary version, the interior of the new car has changed greatly.

As can be seen from the picture, the center console of the new car adopts a very straight line design, so the full LCD instrument is also different from the traditional model. In the middle, there is an embedded central control panel, and the air conditioning outlet is located below the central control panel, and some silver physical buttons are retained, which is equally exquisite. In addition, it can be seen that the new car adopts an irregular gear handle design, and there are two knobs around it, one of which should be the driving mode knob.

Then let’s review the appearance. As can be seen from the previous declaration, the whole shape of the new car has a very strong American pickup style. In addition to a large number of black kits, the front of the new car also has a large area of chrome-plated material, so it is both wild and exquisite.

In the power part, the new car will be equipped with a 2.0T gasoline turbocharged engine of the Great Wall GW4C20B model, with a maximum power of 221 HP (165 kW). As for the specific four-wheel drive structure, we will announce it as soon as there is news.

　　A fantastic journey from Changsha to Hangzhou with a cup of milk tea.

　　Is it illegal to purchase "online celebrity milk tea" across provinces?

　　Recently, Modern China Tea Shop, the "online celebrity milk tea" in Changsha, Hunan Province, was purchased by other provinces, which once again attracted attention from all walks of life. Some netizens broke the news that some people specialize in purchasing Modern China Tea Shop milk tea business and can earn thousands of dollars at a time.

　　● Due to the need for long-distance transportation, inter-provincial purchasing has brought great challenges to the quality and reputation of milk tea. Modern China Tea Shop responded that he did not support any purchasing behavior, hoped that the purchaser would stop this behavior, and also called on consumers not to purchase milk tea.

　　● Does inter-provincial purchasing behavior violate relevant laws and regulations? Some people think that cross-provincial purchasing of online celebrity drinks or food has food safety hazards for consumers and illegal risks for purchasers in different places, so it is best not to try; Some people think that this is a civil agency, not an illegal operation.

　　□ "Rule of Law Weekend" reporter Liu Xiping

　　"Purchasing Modern China Tea Shop, the whole process of high-speed rail freezing preservation, can be purchased in many places, and interested parties can consult … …”

　　Recently, Modern China Tea Shop, the "online celebrity milk tea" in Changsha, Hunan Province, was purchased by other provinces, which once again attracted attention from all walks of life. Some netizens broke the news that some people specialize in purchasing milk tea in Modern China Tea Shop. Buyers buy milk tea from Changsha through the take-away platform, and then take the high-speed train to and from Hangzhou, Zhejiang and other places. After the milk tea arrives in other cities, guests pick up the goods by flash delivery. Buyers can earn thousands of dollars in one trip.

　　On July 14, Modern China Tea Shop responded to this purchasing phenomenon in his official Weibo: "Modern China Tea Shop does not support any purchasing behavior, and hopes that buyers will stop this behavior and also appeal to consumers not to buy milk tea."

　　Whether this cross-provincial purchase of "online celebrity milk tea" violates relevant laws and regulations has aroused heated public debate. The reporter conducted an interview on this.

　　Online celebrity milk tea cross-province daigou

　　You can earn thousands of dollars by running.

　　Modern China Tea Shop is a brand of Hunan Tea Yue Catering Management Co., Ltd.. The company was established in March 2015, focusing on tea and desserts. Because of its high popularity and reputation in Changsha, many consumers buy Modern China Tea Shop milk tea every day, which has become a popular "online celebrity milk tea".

　　However, this "online celebrity milk tea" has recently encountered difficulties in purchasing it across provinces. According to media reports, Modern China Tea Shop milk tea, which sells at 12 yuan in Changsha stores, was purchased by a special person, and the price approached 60 yuan when it arrived in the hands of Hangzhou guests.

　　The informant told the reporter that these purchasing personnel first collected and sorted out orders through the purchasing applet in their city. When the number of orders reached a certain number, they began to take the high-speed train or plane to Changsha to pick up the goods — — Place an order on the takeaway before departure, and contact to pick up the goods after arriving at the train station. Put the goods in a special incubator immediately after they arrive, and then return. Despite the long distance and time, business is still booming.

　　The person who broke the news said that before purchasing orders for 100 cups a day, it has now increased to 200 cups, and it is still in short supply, and the profit per round trip can reach 2,500 yuan. According to reports, the "Latte of Youlan" and "Oolong of Sound" in Modern China Tea Shop are 16 yuan and 15 yuan respectively, and they were sold to 39 yuan after purchasing in Hangzhou. If two people take the high-speed train from hangzhou east railway station to Changsha South Station for purchasing, it will be 1620 yuan for them to take the second-class high-speed train ticket back and forth. If you buy 200 cups at a time, excluding the costs of labor, dry ice, foam boxes, taxis, etc., one cup of milk tea can earn 23 yuan, and 200 cups is 4,600 yuan. Excluding the cost of tickets, two people can earn 2,500 yuan.

　　The reporter combed the news disclosed by the media and found that the business of purchasing Modern China Tea Shop milk tea has emerged in recent years, not only in Hangzhou, but also in Nanchang, Jiangxi, Hefei, Anhui and other cities around Changsha. The mode is that consumers book in advance. After reaching a certain number, the purchaser places an order in advance on the mobile phone, and then takes the high-speed train to pick up the goods and go back and forth one day.

　　There are food safety hazards.

　　Shops crack down on purchasing behavior

　　In the interview, the reporter learned that milk tea with breast covers in summer has a short storage time, so it is necessary to observe whether the cream has melted when drinking. If the cream has melted, it will have a slightly sour taste. In this case, it is generally not recommended to drink, because milk tea has deteriorated, and the deteriorated milk tea contains a lot of sugar, which is easy to breed bacteria.

　　Due to long-distance transportation, it is difficult to guarantee the quality of milk tea. The appearance of inter-provincial purchasing has undoubtedly brought great challenges to the quality and reputation of Modern China Tea Shop milk tea.

　　In the face of the increasing cross-provincial purchasing, Modern China Tea Shop responded in the official Weibo on July 14th that Modern China Tea Shop does not support any purchasing behavior, and hoped that purchasers would stop this behavior, and also appealed to consumers not to purchase milk tea from any channel. Modern China Tea Shop milk tea bought by consumers through cross-city purchasing is not only particularly expensive, but also particularly unpalatable, and it is likely that the milk tea bought is not produced in Modern China Tea Shop at all.

　　Modern China Tea Shop also said that their milk tea is made on the spot, with short shelf life and harsh storage conditions. A cup of milk tea on the spot is transported for a long distance without suitable and stable storage conditions, which poses great food safety risks.

　　"Food safety is greater than the sky, and this kind of purchase that has touched the red line of food safety will be ‘ One-vote veto ’ . As the related report said, in order to crack down on milk tea purchasing, our stores will verify the purchase reasons when they receive large orders. If it is confirmed as a purchasing behavior, the store will refuse to take the order. I really don’t dare to be lucky in everyone’s health, and I hope everyone can understand more. " Modern China Tea Shop said.

　　On the morning of July 16th, the reporter called the escort agency store of Modern China Tea Shop Shuangta International Plaza in the name of ordinary consumers to order 100 cups of milk tea, but the store staff refused to accept this order on the grounds that the order was too large to take orders.

　　However, some insiders believe that it is still unknown whether Modern China Tea Shop’s move has any effect on cracking down on purchasing behavior. "If Modern China Tea Shop doesn’t accept big orders, the purchaser may break them into parts and find some people to buy them locally, which will only increase the purchasing cost."

　　Then, does the railway department have any relevant restrictions on the behavior of carrying hundreds of cups of milk tea on the high-speed rail? To this end, the reporter called the 12306 railway service hotline for consultation on July 15. The railway staff replied that according to the relevant regulations of the railway department, passengers can carry common liquids, such as drinking water, when taking the high-speed rail. "As long as each person carries no more than 20 kilograms. After some trials at the pit stop, you can still bring the high-speed rail. " Obviously, the railway department can’t stop the pace of cross-provincial purchasers.

　　Inter-provincial purchasing sparked heated discussion

　　Whether it is illegal or not is inconclusive.

　　Does this cross-provincial purchasing behavior violate relevant laws and regulations?

　　Some people think that such an inter-provincial purchasing activity actually involves three civil contracts: one is the agency contract between the purchaser and the client, which is an equal and voluntary civil contract. As long as the wishes of both parties are true and the contents involved are not illegal, it is legal and effective, and there is no legal basis for the statement that purchasing can only be limited to acquaintances and friends; The second is the sales contract between the purchaser and Modern China Tea Shop, which is not controversial; The third is the passenger transport contract between the purchaser and the high-speed rail, which is no problem. Since the above three contracts involved in purchasing are legal and valid, it is obviously a bit arbitrary to rashly assert that this cross-provincial purchasing is suspected of illegal operation.

　　"Purchasing milk tea across provinces is a labor income in itself. I don’t think it has reached the level of seriously disrupting market order and should not be illegal." A lawyer in Changsha talked to reporters about his views.

　　Huang Jie, a professor at the Law School of Hunan Normal University, believes that this kind of large-scale purchasing behavior aimed at making profits and targeting unspecified people is suspected of multiple violations.

　　Huang Jie introduced that according to the relevant provisions of the Food Hygiene Law, food producers and operators refer to all units or individuals engaged in food production and operation. Food production and marketing personnel engaged in food production and marketing without obtaining a health certificate, or those who are not allowed to contact directly imported food due to illness and are not transferred according to regulations, shall be ordered to make corrections and may be fined not more than 5,000 yuan.

　　"This kind of inter-provincial purchasing involves the acquisition, storage, transportation, sales and other links in food production and operation. Purchasing personnel engage in food transportation without personal health certificates, which obviously violates the Food Hygiene Law." Huang Jie said that milk tea is easy to deteriorate and breed bacteria after long-distance transportation, which will endanger the health of the client in serious cases.

　　Huang Jie believes that food is a special commodity, and Article 2 of the Food Hygiene Law clearly stipulates that the state implements a food hygiene supervision system. This kind of profit-oriented large-scale purchasing for unspecified objects has already belonged to food business activities.

　　"Because it is out of the supervision of relevant departments, it has actually disrupted the market order and belongs to illegal business activities. At present, according to the analysis of news reports, the circumstances may not be serious, so it is not necessary to apply criminal law to deal with it for the time being. However, if this kind of behavior continues, which constitutes serious circumstances or causes serious consequences, it may constitute the ‘ Other illegal business practices that seriously disrupt the market order ’ Relevant departments can investigate and deal with it according to law. " Huang Jie said.

　　In Huang Jie’s view, this kind of cross-provincial purchasing can easily lead to disputes. "The entrusting party does not know the real name, identity and address of the purchasing party, and it is also difficult to investigate and verify. Many entrusting parties conduct transactions by paying first and then receiving goods, which is prone to the loss, damage or non-conformity of goods. Once there is a dispute over rights and interests, the entrusting party may encounter many obstacles in safeguarding rights. In addition, these ‘ Operator ’ It is also suspected of tax evasion and other issues that violate tax laws. "

　　Huang Jie suggested that purchasing drinks or foods in online celebrity across provinces may pose food safety risks to consumers and illegal risks to purchasers in different places, so it is best not to try.

　　Lawyer Li Jinbao, a partner of Beijing Gancheng Law Firm, believes that purchasing goods belongs to agency behavior and belongs to the legal relationship between consumers and purchasing agents or businesses. "Inter-provincial purchasing ‘ Online celebrity milk tea ’ This kind of purchasing behavior obviously has huge profits, which belongs to paid agency behavior and business behavior, and should be strictly registered according to law. "

　　Li Jinbao analyzed that according to the relevant provisions of the E-commerce Law, which came into effect on January 1, 2019, the for-profit "purchasing" activities that take place in China and undertake and carry out business through information networks belong to e-commerce activities and need to be regulated by the E-commerce Law.

　　"Although there is no clear definition of business activities in the law, business activities have two basic characteristics: facing unspecified objects and aiming at profit." Li Jinbao said that if you buy goods on behalf of specific relatives and friends by traveling, even if you charge a certain reward or reward, it should not be considered as a business activity; And if for the purpose of profit, people buy goods on behalf of many people with high frequency, multiple times and high amount, it should be regarded as business activities and should be bound by e-commerce law.

　　Li Jinbao believes that, according to the requirements of the E-commerce Law, natural persons engaging in "purchasing" business are commercial services, and they must obtain business licenses, obtain corresponding administrative licenses, complete tax registration and pay taxes according to law. "This kind of inter-provincial purchasing ‘ Online celebrity milk tea ’ If there is no relevant qualification, it can be considered as illegal business activities. "