Guangzhou Institute of Biology reveals the molecular mechanism of the transformation process of mouse pluripotent stem cells from the initial state to the original state

  The transformation of cell fate is determined by precise and complex signal regulation and epigenetic regulation, and the study of its molecular mechanism is one of the core problems that need to be solved urgently in the development of cell biology. Studies have shown that mouse pluripotent stem cells have two different states in signal maintenance and function, namely, primitive Epiblast stem cells, EpiSCs) and naive Embryonic stem cells, ESCs). In vitro, these two kinds of pluripotent stem cells can transform each other. Under the stimulation of ActivinA and bFGF signals, naive ESCs can differentiate into primed EpiSCs. On the contrary, by overexpressing a single naive pluripotent gene, such as Esrrb, Klf2, Nr5a2, etc., the initial to naive transition (PNT) can also be realized. Studying the mechanism of cell fate change in mouse PNT process can provide reference for isolating or inducing naive pluripotent stem cells from different species, but the main molecular mechanism of cell fate change in mouse PNT is still unclear.
  On May 11th, Pei Duanqing’s research group and Liu Jing’s research group of Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences published a research paper entitled BMP4 resets mouse epi blast stem cells to naive proliferation through zbtb7a/b-mediated chromatin remolding online in the journal Nature Cell Biology. In this study, we first found that BMP4 can induce PNT in mice, and established an efficient PNT induction system with clear components. Subsequently, high-throughput sequencing techniques such as ATAC-seq were used to reveal the specific molecular mechanism of mouse PNT process.
  At first, researchers found that growth factor BMP4 can induce PNT in mice. With the help of visual reporting system and screening of compound library, it was found that EZH2 inhibitor EPZ6438 and DOT1L inhibitor EPZ5676 can significantly improve the induction efficiency, and then a mouse PNT induction system with a clear chemical composition with an induction efficiency of 80% within 8 days was established.
  On the basis of this platform, researchers combined bioinformatics analysis based on chromatin transposase accessibility sequencing (ATAC-Seq). The dynamic changes of chromatin accessibility in the process of PNT induced by small chemical molecules in mice were described, and it was found that the most critical factor in this system, BMP4, mediated the progress of PNT by regulating chromatin accessibility, on the one hand, inhibiting the opening of differentiation-related sites, on the other hand, promoting the opening of naive pluripotent gene sites. By analyzing the gene sites where BMP4 opens and activates expression, the researchers found that the new downstream targets of BMP4, Zbtb7a and Zbtb7b, regulate the function of PNT by influencing chromatin remodeling. Furthermore, chromatin immunoprecipitation (Chip) proved that Zbtb7a directly binds to and activates the expression of naive pluripotent genes such as Esrrb, Klf2, Nr5a2, thus regulating the occurrence of PNT.
  To sum up, this study established an efficient technical platform for chemical induction of mouse PNT, revealed the molecular mechanism and found new targets from the perspective of chromatin accessibility, and made new discoveries in the study of cell fate transformation mechanism, which provided a new understanding and breakthrough point for the study of chemical regulation of cell fate transformation, and also provided a very meaningful reference direction for other research systems, such as the acquisition of naive pluripotent stem cells in human system.
  Researchers Pei Duanqing and Liu Jing are the corresponding authors of this paper. Doctoral students Yu Shengyong and Zhou Chunhua, Ph.D. students Cao Shangtao and He Jiangping are the co-first authors of this paper.
  Paper link
  Cell fate transition process, chromatin changes and intervening regulatory proteins

Another explosion model, M8, is coming, and it is expected to be listed in the second half of the year.

In 2024, AITO will launch a brand-new model, the M8, with its positioning between M7 and M9, and its estimated price is about 350,000 yuan.

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Taking the asking M9 as a reference, it is expected that the asking M8 will also be equipped with technologies such as Huawei Turing intelligent chassis, megapixel intelligent projection headlights, integrated triple screen, 75-inch AR-HUD and 800v fast charging, and provide two power versions of extended range and pure electricity.

In terms of price, at present, the starting price of Wenjie M7 is 249,800 yuan, and the starting price of Wenjie M9 is 469,800 yuan. It is estimated that the starting price of Wenjie M8 will be somewhere in between, with a high probability of about 350,000 yuan, and it will mainly compete with the ideal L8 after listing in the future.

In terms of intelligent driving, Wenjie M8 is expected to be equipped with HUAWEI ADS 2.0 intelligent driving system like M9, including 1 192-line laser radar, 3 millimeter-wave radars, 12 ultrasonic radars and 11 high-definition cameras. With the integration of sensing BEV, it can identify all kinds of abnormal obstacles and realize the functions of high speed+urban pilot-assisted driving and parking service. In terms of intelligent cockpit, HarmonyOS 4.0 system will also be installed.

In terms of chassis, Wenjie M8 will also adopt Huawei Turing intelligent chassis, including all-aluminum alloy material, air suspension, CDC variable damping shock absorber and other configurations.

With the launch of the M8, it will form a more comprehensive competitive relationship with L series models. At the same time, we will join hands to seize the market of traditional luxury brand BBA.

News observation: China actively promotes multi-path COVID-19 drug research and development.

CCTV News:A few days ago, the reporter learned from the Ministry of Science and Technology that China has arranged COVID-19 drugs according to a number of technical routes, and formed a variety of key drugs, all of which have entered the clinical trial stage. Experts pointed out that vaccines and drugs are complementary "combination boxing" relationship. In the future, it is inseparable from prevention and control measures, vaccines and therapeutic drugs to fight the epidemic.

China has arranged COVID-19 drugs according to three technical routes: inhibiting virus replication, blocking virus from entering cells and regulating human immune system, and formed a variety of key drugs, all of which have entered the clinical trial stage.

According to experts, the three technical routes of drugs in COVID-19 have their own characteristics, and different strategies are adopted to "block" Covid-19’s infection in different physiological links. Take the inhibition of virus replication as an example. By making a "inferior" nucleotide to "cheat" the virus, making it use this "inferior" material in its own replication, directly blocking replication or making the virus "self-construction" a "unfinished project", virus replication can be successfully stopped. In addition, screening high-quality neutralizing antibodies is also a commonly used strategy. Through single-cell technology, the researchers found the "best soldier" to subdue Covid-19. Finding several kinds of neutralizing antibodies, combined with "cocktail therapy", will have a better therapeutic effect on the mutant strains in Covid-19.

According to statistics, at present, there are six kinds of COVID-19-specific drugs independently developed by China, and the two kinds of neutralizing antibody drugs, BRII-196 and BRII-198, are the fastest, which have been involved in the treatment of more than 700 patients in China. The R&D team has submitted the application materials for conditional listing to National Medical Products Administration on October 9, and it is expected to be approved for conditional listing before the end of December.

At the same time, the neutralizing antibody DXP604 has been used as a "sympathy drug" in beijing ditan hospital when patients have no other drugs available, and some patients have recovered after taking the drug.

After the outbreak of the COVID-19 epidemic, relevant enterprises, scientific research units and scientific and technological personnel in China continued to tackle key problems, and relevant departments cooperated in research and examination, actively promoted the research and development of multi-path drugs, quickly selected a variety of therapeutic drugs, and 31 drugs entered clinical trials, which played an important role in consolidating the achievements of epidemic prevention and control, effectively improving the cure rate and reducing the mortality rate.

Experts said that vaccines and drugs are complementary "combination boxing" relationship. In the future, it is inseparable from prevention and control measures, vaccines and therapeutic drugs to fight the epidemic. COVID-19’s therapeutic drugs, together with effective vaccines, are of great value to the formulation and revision of public policies for prevention and control in COVID-19. In the long run, the emergence of oral drugs has injected a "cardiotonic agent" into the world. With the cooperation of drugs, the pace of world opening and economic recovery will be accelerated.

Piloting "9+2" Fourth Guangdong-Hong Kong-Macao Greater Bay Area Development Forum: Promoting Chinese Culture to the World Based on Hongkong.

Photo: Yao Jue, founder and artistic director of Hong Kong String Orchestra (from left), Xu Qinsong, consultant of China Artists Association, and Ma Haowen, executive chairman of Hong Kong Cultural Promotion Association, attended the "Cultural Heritage Exchange and Mutual Learning" forum yesterday. Ta Kung Pao reporter Lin Shaoquan photo

Photo: Yao Jue, founder and artistic director of Hong Kong String Orchestra (from left), Xu Qinsong, consultant of China Artists Association, and Ma Haowen, executive chairman of Hong Kong Cultural Promotion Association, attended the "Cultural Heritage Exchange and Mutual Learning" forum yesterday. Ta Kung Pao reporter Lin Shaoquan photo

  Yesterday (November 24th), at the branch of the 4th Guangdong-Hong Kong-Macao Greater Bay Area Development Forum and Awards Ceremony of Piloting "9+2" held at the Hong Kong Convention and Exhibition Center, a group of guests gathered together to brainstorm and hold a round-table forum on the theme of "Cultural Heritage, Exchange and Mutual Learning" to discuss how to integrate into Greater Bay Area’s development and cultural heritage and innovation, and further promote Chinese culture to the world on the basis of Hong Kong.

  At the sub-forum, Xu Qinsong, consultant of China Artists Association, Ma Haowen, executive chairman of Hong Kong Cultural Promotion Association, and Yao Jue, founder and artistic director of Hong Kong String Orchestra, held a heated discussion. They believed that the development of the Bay Area must complement each other’s advantages, strengthen cultural exchanges, inherit the profound and profound traditional culture of China, and be upright and innovative.

  When it comes to the profound traditional culture of China, Ma Haowen feels the same way. He thinks there are many aspects to learn. In particular, the national "Fourteenth Five-Year Plan" now supports Hong Kong to build a cultural and artistic exchange center between China and foreign countries, and it is even more necessary to uphold tolerance so that all parts of the world can understand China’s excellent traditional culture.

  Make good use of science and technology to break through the boundaries.

  Greater Bay Area culture belongs to Lingnan cultural circle. The speakers not only analyzed each other’s advantages, but also talked about the importance of integration.

  Xu Qinsong is very optimistic about the development of Greater Bay Area, pointing out that Greater Bay Area is an important base for scientific and technological innovation and a highland for dissemination, with good innovation and technological advantages. For example, the "2022 Hong Kong and Macao Visual Arts Biennale" held in Shenzhen last year is based on the theme of "Art and Technology", which is in line with the theme of Greater Bay Area and reflects the integration and innovation of culture, art and technology.

  Therefore, Xu Qinsong believes that the future development of literature and art in Dawan District is not limited to displaying artistic works in a traditional and graphic way, but to make full use of the power of science and technology, expand its influence and go global. Ma Haowen is pleased to see that cultural and artistic exchange activities in Greater Bay Area are becoming more and more frequent. He mentioned the "Centennial Evolution" Guangzhou-Hong Kong Twin Cities Centennial Light and Shadow Exhibition, which was recently opened in the Hong Kong Central Library. He said that the exhibition shows the architectural changes in Guangzhou and Hong Kong under the lens of Greater Bay Area photographers, and the theme is clear and very meaningful. "When Greater Bay Area artists do the same thing, in the process of communication, they can collide with many sparks of ideas and help expand the breadth of promotion."

  Yao Jue said that works are particularly important for the development of Greater Bay Area. "How to create more excellent works from Hong Kong’s excellent culture and go global? We often show Lingnan culture through strings in order to reflect the cultural exchanges between China and the West and then go to the world. " How do young people seek development in Greater Bay Area? She said, "Greater Bay Area is a family and can fully complement each other. Culture is inseparable from communication and experience. Hong Kong’s performance venues are limited, but if it is extended to the whole of Greater Bay Area, four concerts can be held in one weekend, which will be very helpful to young artists in Hong Kong. Similarly, music education in Hong Kong is very rich and can be promoted to the Bay Area. "

  Combining with the trend of traditional culture to rejuvenate the face

  China has a long history of culture. While inheriting it, we can’t ignore innovation.

  Xu Qinsong pointed out the importance of cultural innovation. Taking the recent art space exhibition held in Andy Lau as an example, he praised the other party for jointly holding the exhibition with several artists, using their social influence to plan meaningful projects, putting aside their inherent ideas and being innovative. Yao Jue also said, "While innovating, we must also adhere to our profound cultural heritage."

  Xu Qinsong even called on young people in Hong Kong to visit the Mainland more often. Only by truly understanding the traditional Chinese culture left by their ancestors can their thoughts not be restricted by the inherent framework.

  How can we enhance our understanding so that people all over the world can understand China’s excellent traditional culture? Yao Jue shared his views with personal experience. A few days ago, she led the orchestra to perform in countries and regions along the "Belt and Road". She described that many foreign audiences at the scene listened to wonderful music and wanted to have a look in Hong Kong. They also liked Chinese excellent traditional culture more. "Cultural transmission is very important, and music promotes spiritual communication between people." Yao Jue said.

Jianghuai Ruifeng M3 will go on sale on March 18th, with a pre-sale of 800,000-100,000 yuan.

  Phoenix auto news
Not long ago, Jianghuai Automobile officially announced the model picture of Ruifeng M3, and confirmed that the new car will be officially launched on March 18th this year. A few days ago, Jianghuai Automobile announced that the pre-sale price of Ruifeng M3 was 80,000-100,000 yuan.

Jianghuai Ruifeng M3 Official Map

  In terms of appearance, the new car adopts a younger design style and is more fashionable as a whole. The length/width/height of the car body are 4650/1740/1900 mm respectively, and the wheelbase is 2810 mm.

  As for the interior, the overall design of Ruifeng M3 adopts household style, with clear division of control areas and easy operation. The style of the center console of the new car is steady, but the sense of technology is very prominent. The size of the touch screen is prominent, and the function of the physical buttons below is clearly distinguished. The circular air-conditioning outlet decorated with chrome-plated metal looks very delicate, which undoubtedly enhances the sense of grade of the interior.

  The new car uses a sporty three-spoke steering wheel, and the air outlet of the barrel air conditioner is also quite sporty, which looks like a sports car. The color scheme of the interior is black on the top and light on the bottom. In addition, the central color touch-sensitive LCD screen gives Ruifeng M3 a luxury family car.

  It is worth mentioning that JAC Ruifeng M3 will provide two kinds of seats for consumers to choose from, namely, the seven-seat version adopts 2+2+3 seat layout, the second row adopts double independent seats that can move back and forth, and the second and third rows of seats can be completely disassembled.

  In terms of power, JAC Ruifeng M3 will be equipped with 2.0-liter and 1.6-liter engines to choose from. The maximum power of the 2.0L engine is 143 HP (105 kW) and the peak torque is 175 Nm. In terms of transmission, the engine is matched with a 5-speed manual transmission.

Constantly refresh the record of smart two-wheeled electric vehicles! No.9 company has no conscience, the industry leader.

In recent years, policy support and increased demand have promoted the continuous growth of the number of two-wheeled electric vehicles. The overall development of the industry has made brand competition more intense, and intelligent transformation and safety improvement have become the focus of competition among two-wheeled electric vehicle manufacturers. It is in this situation that Company No.9 (689009·SH) quickly created its own differentiated competitiveness through true intelligence, and created one proud achievement after another.

Offline exceeded 5 million units! No.9 company refreshes the "acceleration" of two-wheeled electric vehicles in China

A thorough study of the history of No.9 Company’s entry into the two-wheeled electric vehicle industry will reveal that compared with other brands, more than four years is really not a long time. But it is this short time that Company No.9 has become an indispensable and irreplaceable existence in the industry.

Not long ago, the fifth millionth intelligent two-wheeled electric vehicle of No.9 Company successfully rolled off the assembly line, and it was only over three months since the fourth millionth one rolled off the assembly line. The amazing growth rate record took 27 months from the first million units, gradually shortened to 11 months, 7 months and 4 months, and increased by 1 million units in the last three months. This is rare in the whole industry. It can be said that it has refreshed the "acceleration" of two-wheeled electric vehicles in China and set a new benchmark.

Not only that, Company No.9 also won four market position confirmations: "Top-end electric vehicles sold nationwide", "Smart electric vehicles sold nationwide for two consecutive years in 2022-2023", "No.9 for every 10 smart electric vehicles sold by China Smart Electric Vehicle Brand" and "China Electric Vehicle Young People’s Preferred Brand", and it is a well-deserved leader in the smart two-wheeled electric vehicle industry.

Operating income reached 4.239 billion yuan, up 34.75% year-on-year, and Q3 performance of No.9 Company reached a new high.

In addition to the amazing success of 1 million units in three months, recently, No.9 Company released its financial report for the third quarter of 2024. The data shows that the company’s operating income in Q3 reached 4.239 billion yuan, up 34.75% year-on-year. The net profit attributable to shareholders of listed companies was 374 million yuan, up 139.07% year-on-year;

It is worth mentioning that, as one of the fastest growing businesses of No.9 Company in recent years, the intelligent electric two-wheeled vehicle achieved 936,300 units in China in the third quarter, and the cumulative domestic sales in the first three quarters reached 2,134,700 units, up 86.08% year-on-year. In addition, this year’s new product No.9 electric motorcycle M95c+ reached the top of the electric motorcycle sales list of Tmall, JD.COM and Tik Tok at the same time, No.9 electric motorcycle from MMAX2 110P won the first place in the electric bicycle sales list of JD.COM and Tmall, and No.9 electric motorcycle N70C won the first place in the electric motorcycle sales list of Tik Tok.

Each of these data proves the strength of Company No.9, and shows that it occupies an indisputable position in the two-wheeled electric vehicle industry. In the future, Company No.9 will continue to maintain this "acceleration", constantly improve the quality of its products and services in the fierce competition, meet the diverse needs of consumers for smart travel, and at the same time promote the high-quality development of the brand itself and the whole industry.

HarmonyOS Zhixing Starlight Night is dazzling, and the top five M9 buildings in the world have become the focus of the industry.

  In the domestic luxury SUV market, the customer M9 is undoubtedly a bright star. With its excellent product strength and market performance, it has successfully broken the monopoly position of traditional high-end brands such as BBA. Now, with the official listing of the top five M9, this luxury feast has been pushed to a climax again, bringing more diversified choices to the high-net-worth users.

  According to the official data, up to now, the M9 has been released for more than eight months, and its delivery has reached 15,386 vehicles, more than twice that of the BMW X5. For four consecutive months, it has been ranked as No.1 in the domestic sales volume of more than 500,000 luxury cars regardless of body form and energy form, and its sales volume has even surpassed the sum of the second to twentieth models in the list. According to the public information, the M9 in China broke the sales record of luxury brand models in the domestic automobile market, and it was the undisputed first among luxury models above 500,000.

  There are five seats in the world of inquiry M9, and six seats in the world of inquiry M9. The differentiated competition shows the truth.

  Recently, the public data of Jielan Road, an automobile industry research institute, shows that the user groups who buy large-size and high-end SUVs all have the commonality of high income, strong purchasing power and high product quality requirements, which can basically be summarized as being young and strong, reading many cars and pursuing the ultimate. What they like in common is that they all like the customized configuration of ultra-luxury SUVs such as fishing benches and champagne cabinets.

  At the peak of M9 sales, we chose to launch the big five-seat version at this time. The differentiation and contrast between the two has become the focus of market attention. From the perspective of user groups, although both belong to the high-end SUV sequence, the user portraits are quite different. With its spacious seating space and excellent household attributes, the six-seat version M9 has won the favor of many consumers who pursue the comfort of family travel. The big five-seat version pays more attention to personal travel needs and drivers’ enjoyment and personality expression.

  According to Jielan Road’s survey of the owners of the M9 in the asking world, the first owners of the M9 in the asking world are mostly engaged in manufacturing, wholesale and retail, and many of them are merchants or entrepreneurs in traditional industries. They have a high income and a well-off family, with an average annual household income of 920 thousand after tax; More than 90% of them are family cars, and luxury brands account for 50%. Even 40% of users said that if the M9 was not released, they would not buy a car. Obviously, this is the greatest affirmation of M9.

  The biggest highlight of M9′ s five blocks in the ever-changing space.

  The sense of vision and space of the M9 five-seater car far exceeds the traditional luxury flagship SUV. The whole car comes standard with Shu Yun seat, which uses Huawei’s patented technology of seat separation, and can be folded and stretched, and the dual-enjoyment mode can be changed with one key. The seat is softer and has better support and fit. The seat comes standard with heating, ventilation and massage functions. The maximum inclination angle of the backrest of the second-row seat reaches 43, and it is equipped with dual electric four-way adjustable leg rest, and the maximum adjustment range reaches 75, which is comparable to the double zero gravity seat in experience.

  When the two rows of central seats are laid down, they can form multifunctional super-large luxury handrails, which are wrapped in NAPPA leather, and the color matching of solid wood decorative panels and door panels is consistent. Integrated with dual 50W wireless super fast charging and 66W wired super fast charging, equipped with oversized double cup holders, mobile phone slots, storage boxes, etc., it is both luxurious and practical. Users can switch between the flagship five-seat and luxury four-seat layouts at any time.

  The M9 five-seater car has 38 storage spaces, including fully enclosed central lockers, private lockers for the main driver and exclusive side cabinets for the co-driver. The storage space of the five-seat trunk of Wenjie M9 can be flexibly adjusted, and it is equipped with a variety of luxury accessories such as double slide rails, loading trays and boutique storage boxes, which can broaden more application scenarios.

  Play new tricks in the trunk and create more luxury life.

  The super DIY combination ability of the trunk is also very attractive. The space of the trunk with five seats in the M9 is far beyond the same level, and it can easily accommodate four 28-inch suitcases and one 20-inch boarding box under normal conditions. The two rows of seats are laid down, and the trunk volume reaches the largest in the same class, which can easily accommodate pulp boards, golf bags, snowboards and other items. At the same time, the top five seats of the M9 in Wenjie are equipped with double slide rails, and the trunk space can be expanded with a variety of luxury accessories, such as limiters, loading trays, boutique storage boxes, mountain and sea seats, etc. Through these accessories, the five-seat M9 can be turned into a camper, and you can get close to nature and enjoy life anytime and anywhere.

  Huawei’s black technology is fully on the bus, and technology leads the future travel.

  As the flagship model of Huawei HarmonyOS Zhixing, the technological sense of the M9 has been well received and recognized by everyone since its listing. HUAWEI XPIXEL Megapixel Smart Projection Headlights, HarmonyOS Smart Cockpit, HUAWEI ARHUD Head-up Display System, HUAWEI ADS 3.0 Advanced Intelligent Driver Assistance System, and other top ten smart car black technologies all appeared, bringing unprecedented intelligent travel experience to drivers and passengers. In addition, the top five seats of the M9 also added comfortable braking, non-inductive braking and other control configurations to make driving easier.

  The listing of the top five M9 seats not only injects new vitality into the luxury SUV market, but also provides more diversified choices for high-net-worth users. From the sales performance to the product performance, the M9 has demonstrated its great strength as a representative of high-end automobile brands in China. We have reason to believe that in the future market competition, M9 will continue to maintain its leading position and lead the luxury SUV market in China to a higher and further direction.

  After the successful conclusion of the press conference, "HarmonyOS Zhixing Starlight Night" was as bright as a star. At the event site, the presence of Hu Jun, Liu Yijun, Christy Chung, Tu Songyan, Vengo, Lingyun, Laure Shang and other star guests added infinite starlight to the event. These stars not only shared the warm stories with M9, but also conveyed their sincere feelings about this new car. The event was a great success, which not only won wide acclaim in the industry, but also showed the brand charm and market potential of M9 in the world.

For sale, 174,800 ~ 202,800 MG MG7 is listed automatically.

  [Information] On September 19th, the announced AT market price was 174.8-202.8 million yuan. this timeThere are three models of MG7 AT: comfort version, luxury version and ultra-luxury version. The prices are: 174,800 yuan for MG7 AT comfort version, 186,800 yuan for MG7 1.8T AT luxury version and 202,800 yuan for MG7 1.8TAT ultra-luxury version., and,,, form a market competition relationship. 1.8T all-aluminum racing-class engine, 10-mode intelligent automatic manual transmission, national IV emission standard and the innovative spirit that British cars have always emphasized are all revealed on MG7 AT.

Ten-mode intelligent automatic manual transmission and all-aluminum racing engine are passionately matched.

  Over the past year, MG7 has won many praises in the market for its quality, performance and taste by relying on manual transmission products, and the strong launch of automatic transmission not only means the new strength of this British high-performance car, but also means that the living space of MG MG market will be greatly expanded.

  MG7 adopts a 1.8 turbocharged all-aluminum racing engine, with a maximum output of 118kW at 5500rpm and a maximum output of 215N·m in a wide range of 2100-4000 rpm. In terms of fuel consumption, it continues the consistent low fuel consumption of MG7, and the constant-speed fuel consumption of MG7 AT (theoretical fuel consumption) is 90km/h ≤7.5L/100km, which is very prominent among automatic transmission models of the same class.

  High-performance engines naturally need to match high-performance gearboxes. For this reason, MG MG teamed up with Aisin, the world’s first transmission research and development company, to jointly develop the Tiptronic 10 intelligent automatic manual transmission carried by MG7 AT. What’s more worth mentioning is that in order to ensure the true colors of MG7 AT British high-performance car, MG cooperated with experts from China, Britain, Japan and Germany to match and adjust the powertrain and chassis of MG7 AT in all directions. It has sports mode, snow mode, economy mode, mild overheating protection mode, severe overheating protection mode, preheating mode, low slope mode, high slope mode, etc., and has obvious exquisite style of Japanese transmission. It is matched with the MG MG 1.8T powertrain, which gives consideration to comfort and economy on the basis of ensuring maneuverability.

  Many modes ensure that drivers don’t have to think too much when driving. The gearbox will judge the driving condition of the car according to the feedback signal of the sensor. When the mode conditions are met, the gearbox will automatically switch to the corresponding mode to help drivers drive the car easily and effectively. In order to ensure the control pleasure that MG MG has always emphasized, a separate area for manual shift operation mode is set on the right side of the gearbox shift lever, so that drivers can intervene at any time and enter the manual shift mode to improve driving pleasure.

  A good car also needs a good chassis. The chassis of MG7 AT is adjusted by a British company for different road conditions. MG7 AT adopts a compact front independent suspension and a MG Z-shaped longitudinal swing arm rear independent suspension.

Appearance dynamic passion configuration humanized bonus points

  On the basis of manual transmission, this model has been upgraded in humanized configuration and appearance. In addition to the change of gearbox, the appearance is more passionate and dynamic. MG7 AT retains beautiful lines, chrome-plated decorative strips are added to the periphery of the kidney-shaped mesh grille, and chrome-plated decorative strips are also added to the front and rear bumpers, which complement the original metal waistline and show more confidence.

  On the other hand, the "humanized design" is further added, such as 6-disc CD, 7-inch LCD screen, independent control constant temperature air conditioner with dual temperature zones, electric folding exterior rearview mirror, intelligent folding key, sunshade mirror with lighting function and other configurations show humanistic care.

  In terms of comfort configuration, MG7 has also continued its previous style, and applied advanced equipment such as 8-way memory seat, reversing image, ultrasonic anti-theft, left and right independent control automatic air conditioner, which was only available in top-mounted vehicles, to improve the comfort and convenience of the whole vehicle.

  In terms of safety configuration, the MG7 automatic transmission follows the laser welding process of manual transmission, which ensures the rigidity of the whole vehicle. The body is made of a large number of high-strength steel, and various parts of the body are made of variable cross-section laser tailor-welded, which ensures the firmness and energy absorption of the body to the maximum extent. In addition to the high-tech configuration such as double safety,+,intelligent anti-glare interior rearview mirror, speed-sensing automatic door lock, etc., at the same time, MG7 AT and the body structure jointly developed and the special design method make it stronger and can absorb energy in multiple stages, which improves the passive safety effect. The front and rear four-wheel ventilated brake discs are equipped with electronic alarm devices to monitor the wear of brake pads. In addition, the five-fold anti-theft measures adopted by the vehicle completely ensure the safety of the whole vehicle from five aspects: engine, battery, intrusion prevention, tires and even fuel tank.

MG7 Auto-gear MG stepped into a new harvest period.

  The medium-sized car market has always been the main battlefield for major manufacturers to compete for. For a long time, the first echelon of this market has been firmly occupied by the seemingly moderate business and household models, such as,,, and so on. While many second echelons formed by individual models are not as impressive as those of the first echelon, their strong vehicle features also attract a large number of fans, the most representative of which are 6, Magotan and-winning. Although the previously launched MG7 MT is also full of sports flavor, it cannot compete with the first three models because it only has a manual version and does not constitute a complete car system. Now that MG7 AT is about to be launched, the reloaded MG7, as a new force of sports medium-sized cars, challenges the so-called "top three sports".

Car home Nanjing MG MG7 1.8T Deluxe Edition

  The listing of MG7 AT marks that MG MG has entered a new harvest season. As far as MG MG Company is concerned, it has been a whole year since the first product MG7 MT of MG MG MG went on the market. During this year, MG MG allowed consumers to know MG MG, a pure British brand, to have MG MG MG’s passionate and excellent products, and to launch small personalized products to expand the consumer base. Make MG products cover the market from medium-sized cars to small cars.

  From the MG7 manual transmission model to the introduction of the carefully crafted automatic transmission version, it seems that it is only a change in the gearbox, which in essence makes the MG7 product series more complete, and it is also the wing for MG7 to take off in the medium-sized car market in China. The appearance of MG7 AT is a new force to be reckoned with in the medium-sized car market, which is known as the "wind vane of the automobile market".

 

Biden made a slip of the tongue in an interview by saying the wrong name of the president during the Great Depression (photo)


Biden, who has rich experience, also got the president’s name wrong during the Great Depression.


  Beijing, Sept. 24 (Xinhua)-In the current US general election, from the primary election of the two major parties to the current campaign, it seems that it has become a common occurrence for candidates or candidates to make slips of the tongue, say the wrong words or quote wrong data. Biden, the Democratic vice presidential candidate, made a mistake in the name of the American president in the Great Depression when he was interviewed by a TV station recently and expressed his views on the recent financial tsunami.


  According to Sing Tao Global Network, Biden said in an interview with the CBS evening news program that the leaders of today’s generation should learn from history books and learn from the late American President Roosevelt how to respond to the financial crisis.


  Biden said: "Do you know? When the stock market crashed, Roosevelt went on TV, not only complaining about how greedy others were. He said,’ Look! This is happening now!’ "


  However, looking up the history books, when the American stock market plunged in October 1929, which opened the curtain for the Great Depression, the president was not Roosevelt who belonged to the Democratic Party, but Hoover who belonged to the Republican Party. Roosevelt was elected to the White House three years later, that is, in the election year of 1932, and Hoover failed in his re-election. During his campaign, Roosevelt promised to take new actions to lead the country out of economic difficulties.


  It seems that Democrats often want to deliberately remind the public and voters that when the stock market crash triggered the Great Depression in 1929, the Republican Party was in charge. In the election year of 2004, the then Democratic candidate Kerry also repeatedly used Hoover as a topic, saying that he was the president who witnessed the shrinking employment position during his last term of office, followed by Bush.


  Commenting on the recent stock market crash, Biden said that leaders of today’s generation should explain to the public the current economic crisis and how to solve it. He pointed out: "As a leader, what you should do is to slowly restore the public’s confidence, show that they know what happened, and communicate with the public to explain how to solve the problem."


  This is not the first time that this presidential candidate or primary candidate has said something wrong. I remember that during the Democratic primary election, Hillary Clinton, a female senator from New York, once boasted and recalled the scene of bullets at the airport when she arrived in Bosnia by plane, but the reporter looked at the news clips and there was no such thing at all.

Editor: Meng Xu

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