Cctv newsOn April 28th, the joint prevention and control mechanism of the State Council held a press conference to introduce the development of agriculture and rural economy during the epidemic and answer questions from reporters.

　　The reporter asked how to promote agricultural production and green development as a whole.

Liao Xiyuan, Director of Science, Technology and Education Department of Ministry of Agriculture and Rural Affairs

　　Liao Xiyuan, director of the Department of Science, Technology and Education of the Ministry of Agriculture and Rural Affairs, said that in recent years, the Ministry of Agriculture and Rural Affairs has thoroughly implemented the new development concept, put the green development of agriculture in a prominent position, and promoted reduction and efficiency, green substitution, planting and breeding cycle and comprehensive management, and achieved remarkable results. The use of chemical fertilizers and pesticides is less, the manure in the pigsty becomes treasure, the straw is used better, and the recovery rate of agricultural film is higher. This year, we will continue to adhere to the direction of green agricultural development and further intensify our work.

　　First, focus on strengthening policy support. Improve the green-oriented agricultural subsidy system, improve the agricultural ecological compensation mechanism, and improve the management methods such as reducing the use of agricultural inputs, classified management of cultivated land, and conservation of agricultural resources.

　　The second is to focus on implementing the five major actions of agricultural green development. Carry out the action of replacing chemical fertilizer with organic fertilizer in 175 counties in the advantageous production areas of fruit, vegetable and tea; Implement the action of recycling manure in 685 livestock production counties; Implement comprehensive utilization of straw in 200 counties; Implement agricultural film recycling operations in 100 counties; Take the Yangtze River Basin as the focus, and carry out aquatic life protection actions.

　　The third is to focus on strengthening scientific and technological support. Deepen cooperation in Industry-University-Research, organize superior scientific research units and enterprises, carry out joint research on key technologies of agricultural eco-environment, release major leading agricultural green production technologies, and promote 100 leading technologies with high quality, safety, cost saving, high efficiency and eco-friendliness.

　　The fourth is to focus on improving the monitoring network. Weave a "net" for agricultural ecological environmental protection monitoring, improve 40,000 national monitoring points such as cultivated land soil environmental quality, 240 farmland nitrogen and phosphorus loss, 500 agricultural film residues and 280 straw resources, strengthen monitoring and evaluation, and promote supervision and assessment in an integrated manner.

Special feature of 1905 film network　　　In the 47th week of 2018 (from November 19th to November 25th), the market data decreased slightly from last week, closing at 880 million. In recent days, "Nobody", which has been continuously fermented by word of mouth, successfully achieved a counterattack, and reached the top with nearly 280 million results in the second week under the attack of a number of foreign films; The old film Venom is still strong, winning the runner-up with 250 million; The third place was won by the new film "Invincible Destroyer 2: Make a scene on the Internet". At the same time, big data shows that the annual box office in the mainland finally surpassed the previous year this Sunday, breaking through the 55.9 billion mark 36 days ahead of schedule and moving further towards the goal of 60 billion for the whole year.

Word-of-mouth fermentation of "Nobody" reached the top, and "Invincible Destroyer 2" commented on two poles.

At the early stage of its release, The Nobody was angry with a wave of existence because its score continued to rise after the opening of the painting. However, due to the opponent’s "Fantastic Animals: The Crime of Grindelwald", the box office of the former was still suppressed. However, in the next week, with the continuous strong fermentation of word of mouth, the popularity of "Nobody" gradually surpassed that of "Fantastic Animals", and the box office also rose. Since it overtook Venom on Wednesday, the film has been firmly at the top of the list, and even the newly released Disney animation "Invincible Destroyer 2: Make a scene on the Internet" failed to shake it. At present, the box office of the film has quietly approached 350 million, and the spring of good actors has taken another head in this cold winter.

For six years,Wreck-It RalphLaunch a sequel. With the human society stepping into the Internet 2.0 era, the protagonists in movies have also gone from the video game world to virtual cyberspace. This high degree of synchronization between life and the plot makes the stalks in Invincible Destroyer 2: Make a scene on the Internet more entertaining. At present, the film has a good reputation, with Douban score of 8.4 and ticketing platform score higher than 9, so ordinary viewers can find endless fun in the overwhelmed eggs. However, for many fans who have been waiting for "wreck-it ralph" for many years, the story of the sequel seems to be not as amazing as it was when it was first seen in those years. Many people think that the high degree of pan-entertainment has damaged the depth of the plot, which is a pity. This is also a common contradiction in sequel to the movie’s continuous creation.　

The annual box office exceeds 55.9 billion, breaking the 2017 record. Can the mainland film market reach 60 billion in 2018?

This Sunday afternoon, the mainland film market ushered in exciting good news. 36 days before the end of the year, the mainland box office successfully broke through 55.9 billion yuan, setting a new record set last year and starting to move on to new goals. Looking back on the past 11 months, we have not only experienced the absolute glory of the Spring Festival file to help break through 10 billion yuan in a single month, but also the summer file with a high of 16.3 billion yuan, and also survived the shock that the box office continued to fall in a single week and the overall market was cold. Next, the suspense left for 2018 is whether the 60 billion target can be achieved in the next 30 days.

As we all know, the popular lunar new year’s eve file started in December. In 2017, the mainland film market won nearly 5.1 billion in that month, including 11 films that broke 100 million. Looking at the film list, the popular films that have been booked at present include Neptune, Chinese Partner 2, Wulin Monster, Amateur Agent, Spider-Man: Into the Spider-Verse, Weather Pre-explosion, Legend of Ip Man: Zhang Tianzhi, Worm Valley in Yunnan, The Last Night on Earth, etc. Theoretically, it is possible to achieve the goal.

Week 48: Crazy Rich Asians’s old film showing the grievances of the giants is expected to continue to attract gold.

Among the new films opened this week, Crazy Rich Asians has the highest topic. The original English name of the film is Crazy Rich Asian, which tells the story that Rachel, an ordinary girl, accidentally learns that her boyfriend’s family is a super invisible rich while accompanying her boyfriend home to visit relatives, and then faces a series of tests. As an all-Chinese work, the film has also caused extensive discussion in Hollywood after its release. The global box office of $260 million also made this film "the light of Chinese". From the story point of view, this is a high-level inspirational version of Meteor Garden, which is entertaining and educational, and it is a "cool film" that can relax the brain.

There are not many other works of the same period, and many old films released this week still have a chance to attract gold for a week.

　　[PConline evaluation]As a niche old brand, "800 million time and space" seems more like a sentimental existence to some old users. Since the brand was founded in 1992, it has been committed to the PC market. In 2001, it was among the top ten famous brands in China. After the subsequent transformation, it engaged in the research and development and production of liquid crystal display materials, became the main domestic liquid crystal material provider, and gradually faded out of the consumer market.

　　Until this year, Huishijie Electronics Co., Ltd. was authorized by the brand in the field of 800 million time and space display, and the "800 million time and space" products returned to the PC market. BM320F is the masterpiece of big screen, with 32-inch IPS-ADS panel and 10.7mm slim steel frame, which strives to bring strong visual impact to consumers in both display effect and appearance.

● Monitor specification parameters

　● Introduction to the features of BM320F in 800 million time and space:

　　The above table lists the basic parameters and features of this new product. You can read it in detail to deepen your understanding of this product. Let’s start with PConline and make a detailed evaluation of it.

Appreciation of appearance and details of BM320F in 800 million time and space;

　　800 million time and space BM320F is a 32-inch large-screen display, which is made of IPS-ADS panel material, closely follows the fashion trend in appearance, and incorporates the minimalist design concept and extremely narrow bezel, making this display more eye-catching.

　　The clean back is made of matte texture, and the screw holes on the back indicate that this large-screen monitor supports wall hanging function.

　　BM320F will make the fuselage thickness 10.7mm in 800 million time and space, and the slim design will make the fuselage light and thin. Aluminum alloy middle frame is used around the screen to ensure the strength of the fuselage.

　　The border of the 800 million-hour BM320F is one of its appearance features. The super-large screen size is matched with the extremely narrow border of only 6.7mm, so that the line of sight is not limited by the border, thus having a better view.

　　BM320F in 800 million time and space puts the physical OSD button at the back of the display with the logo on the front, which is both beautiful and convenient to operate.

　　Electroplated aluminum alloy die-casting base, beautiful luster, showing gorgeous and elegant temperament.

　　In terms of interface, it is equipped with two common video input interfaces, DVI and VGA, which basically meet the needs of users for multi-platform access.

　　According to the nameplate information, the power of this 32-inch large-screen monitor is only 35W, and its energy-saving and environmental protection features make it suitable for bulk purchase in Internet cafes, offices and other places.

● Gray scale test

　　Gray scale refers to the hierarchical relationship between the darkest black and the brightest white of a display. In terms of contrast between light and dark and black and white color transition, the clearer the image, the more natural the transition, the better. On the gray scale, the performance of 32-level gray scale and 256-level gray scale is mainly used for testing.

　　In the 32-level gray-scale real shot, the color scale display of BM320F in 800 million time and space is relatively general, although there is no obvious color difference, and the gradient range is small. The boundary of some color blocks in the upper left corner is not clear, so it is difficult to distinguish.

　　However, it performed well in the 256-level gray scale test. It can be seen from the real shot that this gray scale gradient has a wide transition range, and the transition is more natural and distinct than the 32-bit gray scale, and most of the squares are completely displayed.

● Test

　　In terms of color saturation, the brighter and more transparent the picture displayed by the display, and the smoother the transition, the better the performance, and vice versa.

　　800 million time BM320F adopts IPS-ADS panel, which has good performance in color saturation, clear image quality and full color. Excessive is natural, and the color has high permeability.

● Test

　　In the real shot, there are slightly dark areas on the left and right edges of BM320F screen in 800 million time and space, but the overall dark part is not obvious, which is good enough for a 32-inch screen.

　　There is no light leakage at the edge of the screen when the monitor is in a real black picture. Excellent performance.

● Contrast test of image restoration effect

　　The following chart is a comparison between the real shot and the original picture, from which we can basically see how the color reproduction effect of a display is.

　　Note: Due to the shooting of the camera, there will be some loss in the real shot picture, and the style of the picture will be different due to the different cameras. Here is for basic reference only.

　　It can be seen from the comparison chart of the color reproduction effect of the picture that the BM320F display in 800 million time and space has a deep reproduction of the red in the three primary colors, and the other colors are still more accurate; In the natural scenery picture test, the color of the safflower picture is biased, and the color is more orange. The green plant map is slightly brighter; The ultra-high contrast of this monitor is excellent in LCD pictures, which can highlight the details of the picture. The character’s skin color is slightly brighter, and the overall restoration effect is more natural and delicate.

● Measured data of BM320F display in 800 million time and space.

　　The 800 million space-time BM320F adopts IPS-ADS high-definition panel, and the viewing angle can reach 178. From the real shot pictures, the multi-view images are uniform, the colors are consistent and the brightness distribution is uniform. It can easily meet the viewing needs of users from different angles.

● Display brightness | Contrast | Color gamut | Color temperature | Color level | Brightness uniformity test

　　The following data were tested by the professional monitor screen color correction instrument "Starscream Spyder4Elite 4". The test items include color gamut coverage, color reproduction accuracy, color temperature consistency, chromaticity uniformity, brightness uniformity, gamma curve and so on.

Color temperature of ambient light: 6500K K.

Ambient light illumination: 51Lux

Signal input: DVI

Comply with ISO3664 standard.

● Color gamut test:

Color gamut coverage: 97% sRGB 76% AdobeRGB

　　After measuring the color gamut of this monitor, it is found that its sRGB color gamut can reach 97% and Adobe RGB color gamut can reach 76%, and the color gamut coverage is relatively normal, which basically meets the needs of mass users for color diversification.

● Brightness uniformity test

　　According to the brightness uniformity test, the brightness value of 225.1cd/㎡ in the center of BM320F is the highest, while the brightness value in the lower left corner is the lowest, which is 198.3cd/㎡, and the brightness difference is 12%. Compared with the 32-inch screen, the overall uniformity is controlled in an acceptable range, and the overall screen display is even and soft.

● Color temperature consistency test:

　　The purpose of color temperature consistency test is to test the stability of white point color temperature of display under different brightness.We test the brightness of all-white picture and all-black picture as well as chromaticity coordinates when the brightness level is 0%, 25%, 50%, 75% and 100% respectively, and calculate the contrast and color temperature values. The color temperature value and contrast ratio should not change much under each brightness.

　　In 800 million time and space, the white point color temperature of BM320F is kept at 7300K under different brightness, and the performance is very stable. Compared with the standard 6500K color temperature, the overall display effect is slightly cooler.

● Color standard test

　　In terms of color accuracy, Δ E value is regarded by us as a key indicator to measure the quality of a product, Δ The closer e is to 1, the more accurate the color standard is. The average of this monitor Δ E is only 1.11, which is very close to the standard level, and the overall performance is excellent. And Δ The maximum value of e is only 3.81, which shows that this monitor has a high level of accuracy in color reproduction.

When △E≤ 1, the human eye can hardly distinguish the difference between the two colors;
When 1<△E<3, the human eye needs to be able to distinguish subtle color differences after comparison;
When △E<5, the human eye can distinguish the color difference and consider it as two similar colors.
When △E>5, most people can see the color difference and think it is a completely different color.

Summary of PConline evaluation room:

800 million time and space BM320F　　picture　　evaluating　　forum　　quote

　　As a large-screen display suitable for Internet cafes and home audio-visual entertainment, the 10.7mm slim body and 6.7mm ultra-narrow bezel of the 800 million-hour BM320F, supplemented by baking paint, have a noble and simple appearance. In terms of screen display, the performance of BM320F is also remarkable. IPS-ADS panel provides ultra-wide visual range and 16.7M color number display, and the performance of color reproduction accuracy is in the upper-middle level.

　　800 million time and space, after many years to return to the consumer market, not only to reconsider the current market demand, but also to get consumer recognition of its brand. Therefore, 800 million time and space promised to provide an effective warranty for BM320F for up to three years, so as to dispel users’ concerns about product quality. At present, the price of this product is 1299 yuan, which is very cost-effective. Friends who like to pursue big-screen entertainment may wish to consider it.

　　On April 11th, 2018, the Central Committee of the Communist Party of China and the State Council issued the Guiding Opinions on Supporting Hainan’s Comprehensive Deepening of Reform and Opening-up. Subsequently, the Ministry of Transport set up a working group to promote the comprehensive deepening reform and opening up of Hainan’s transportation, and planned ahead and took the initiative to dock with unconventional ideas and support. On July 25 of the same year, the Ministry of Transport issued an implementation plan for implementing the Guiding Opinions, which took the lead in sounding the horn of the central state organs to support Hainan’s comprehensive and deepening reform.

　　Over the past year, a series of reforms, initiatives and explorations in the field of transportation have added infinite vitality to Hainan. Today, 26 specific policies and measures and 76 key tasks proposed in the implementation plan are taking root in Hainan, and 12 tasks have achieved initial results.

Haiwen bridge

　　As the largest special economic zone in China and a relatively independent geographical unit, Hainan’s economic aggregate and population size are relatively small, and policy risks are easy to control, which has the unique advantage of becoming an experimental field. Opening the "last mile" of the comprehensive transportation corridor and building an integrated transportation system covering Hainan’s land area and 2 million square kilometers of marine land will accumulate valuable experience for comprehensively promoting the construction of a transportation power.

　　In the implementation plan, the positioning of "comprehensively deepening the reform of transportation, expanding the opening-up pilot area and building a transportation power" has given Hainan an important mission to demonstrate and lead.

　　Infrastructure comes first. "We fully support Hainan to accelerate the construction of a safe, convenient, efficient, green and economical modern comprehensive transportation infrastructure network." The relevant responsible comrades of the working group of the Ministry of Transport to promote Hainan’s comprehensive and deepening reform and opening up said.

Qiongle Expressway

　　During the Thirteenth Five-Year Plan period, the Ministry of Transport continued to increase its support for Hainan’s transportation. With the joint efforts of the Ministry and the province, Hainan’s modern transportation system has taken shape.

　　However, the effective supply capacity of infrastructure is still insufficient, and the energy level and level of airports and seaports in the global aviation and maritime network nodes are low, and there are still shortcomings in the new national strategic requirements for benchmarking the construction of free trade zones &hellip; &hellip; Pieces of short boards stand out in front of you.

　　How to make up for the shortcomings? The first task put forward in the implementation plan is to guide Hainan to work out the medium and long-term development plan of the comprehensive transportation system with high standards, high positioning and high starting point. Since 2018, the Ministry of Transport has instructed Hainan to actively connect with the traffic plan of Guangdong-Hong Kong-Macao Greater Bay Area, and to prepare this plan with high standards, high positioning and high starting point.

　　According to the preliminary research results, the spatial layout of infrastructure with "one belt, two sectors, three vertical connections and four horizontal connections" is coming to the fore.

　　Plan the path and point out the direction. In 2018, the Ministry of Transport increased financial support for Hainan’s transportation infrastructure construction, accelerated the construction of Qiongzhong-Ledong, Wenchang-Qionghai and Wanning-Yangpu expressways, promoted the construction of Wenchang-Lingao Expressway and Haiwen Bridge (Puqian Bridge), the waterway and breakwater project in Macun Port Area of Haikou Port, and carried out the preliminary work of Sanya New Airport and other projects.

　　One by one, the projects under construction and planned to be built have gradually formed the framework of Hainan’s modern comprehensive transportation infrastructure network. In September 2018, an important part of the "Tian" shaped expressway network in Hainan Province &mdash; &mdash; Qiongle Expressway was completed and opened to traffic, and the middle line expressway was fully connected. On March 18th this year, Haiwen Bridge was opened to traffic, shortening the driving time from Haikou City to the famous hometown of overseas Chinese, Wenchang Puqian Town, from one and a half hours to 20 minutes.

Developed expressway network

　　On April 13, 2018, General Secretary of the Supreme Leader solemnly announced at the celebration of the 30th anniversary of Hainan’s establishment of a provincial special economic zone that the CPC Central Committee decided to support the construction of a free trade pilot zone throughout Hainan and the gradual exploration and steady promotion of the construction of a free trade port with China characteristics.

　　Hainan has ushered in a new world of deepening the all-round opening-up in the field of international shipping, the integration of port and shipping and the "streamline administration, delegate power, strengthen regulation and improve services" reform, and it has also ushered in the greatest opportunity for development and the strongest comparative advantage.

　　"Promote Hainan to stand out in the national maritime opening up, create a market environment that comprehensively deepens reform and is highly open, form a competitive advantage, and attract global maritime resources to gather!" The Ministry of Transport has a firm attitude.

　　To this end, the Ministry of Transport has promoted Hainan to take the lead in fully opening up the field of international shipping, allowing foreign businessmen to set up wholly-owned enterprises or joint ventures with unlimited share ratio in Hainan to operate various international shipping and auxiliary businesses such as international shipping and international ship management. Cooperate with relevant parties, the Ministry of Transport will copy and promote all the existing pilot policies for expanding and opening up the free trade zone to Hainan, and guide it to implement the negative list management system of national treatment plus investment before foreign investment access; For international shipping agencies registered in Hainan, the limit of foreign-funded shares not exceeding 51% shall be abolished.

　　The Ministry of Transport also supports Chinese-funded non-five-star Red Flag ships to carry out coastal piggyback business with the port of Hainan Free Trade Zone as an international transit port, study and explore a more open international ship registration system in Hainan, and promote the sharing of relevant certificate information in ship inspection, maritime affairs, port and shipping departments.

　　Most of the world’s free trade zones and free trade ports are built on the basis of Hong Kong and prospered because of it. The implementation plan proposes to focus on supporting Haikou Port and Yangpu Port to become better and stronger, and Sanya, Basuo and Qinglan ports to make their own characteristics.

　　On July 2, 2018, the Hainan Provincial Government signed a strategic cooperation agreement with COSCO Shipping Group to support COSCO Shipping to take the lead in integrating Hainan’s port and shipping resources. At the end of that year, Hainan, the "new channel for international land and sea trade", was launched and COSCO Shipping "Hainan &mdash; The maiden voyage of the ASEAN (Singapore) liner route stirred up waves at sea level.

　　The data shows that in 2018, the port cargo throughput of Hainan Province reached 183 million tons, and the container throughput reached 2.4 million TEUs, up 14.7% year-on-year; The number of international container liner routes increased to 9, and the number of domestic container liner routes increased to 33.

Haikou port

　　The vision turned to Qiongzhou Strait in the north of Hainan Island.

　　In the Spring Festival of 2018, a continuous fog that has not happened in 67 years came unexpectedly. The navigation of passenger ro-ro transportation in Qiongzhou Strait was limited, tens of thousands of cars were stranded in Haikou, and more than ten kilometers of Binhai Avenue became a parking lot. The long wait makes tourists feel anxious. This concentrated on exposing the shortcomings and pain points of passenger ro-ro transportation in Qiongzhou Strait.

　　The pain point is where the force is exerted.

　　The Ministry of Transport, together with Hainan, Guangdong and Guangxi provinces, issued the "Three-year Action Plan for Improving the Passenger Ro-Ro Transport Service Capacity in Qiongzhou Strait (2019&mdash; 2021), actively promote liner operation, study and promote the "separation of passengers and cars" on boarding and disembarking, and urge relevant port and shipping enterprises to launch WeChat WeChat official account ticketing services. During the period of Spring Festival travel rush in 2019, the passenger ro-ro transportation in Qiongzhou Strait provided efficient, convenient and high-quality services for people traveling between the two sides of the strait, and safely transported 3.6 million passengers and 750,000 vehicles, without serious detention of passengers and vehicles.

　　Streamline administration, delegate power, strengthen regulation and improve services’s reform of transportation in Hainan Province has also gained more support. In 2018, Hainan achieved 64 items of "no face-to-face approval" ahead of schedule, and the "commitment time limit" of 80 administrative examination and approval items involved was all reduced by 50%.

　　On January 31st, "Westdan", a world-renowned cruise company owned by Holland America Cruises, arrived in Sanya, becoming the first international cruise ship to visit Sanya this year, bringing in 1,855 inbound tourists, of which about 85% were from Europe and America, which became a story of the handover between Sanya’s tourism industry and the world cruise industry.

Sanya Phoenix Cruise Terminal

　　Nowadays, cruise yacht tourism has become the most dazzling business card of Hainan tourism and an emerging industry with characteristics, potential and competitiveness.

　　As the only tropical island province in China, Hainan has a unique resource advantage in developing cruise yacht industry. Under the guidance of the Guiding Opinions, Hainan’s road to building an international tourist island is getting wider and wider.

　　The implementation plan proposes to support cruise enterprises to develop cruise routes involving Hainan, advance the pilot of Hainan cruise destination routes, support the development of local cruise ships, and expand Hainan cruise market.

　　Today, these measures are being gradually implemented. The Ministry of Transport took the lead in guiding Hainan to introduce preferential policies to promote the agglomeration of cruise elements, researching and formulating pilot policies for Chinese-funded flag of convenience cruise ships at sea, supporting cruise ports such as Sanya to carry out pilot projects, extending the yacht free travel policy of Guangdong, Hong Kong and Macao to Hainan, establishing a yacht type inspection and filing management system, and promoting the establishment of a port management model of "fixed-point docking and joint inspection nearby" for yachts from Qiong, Hong Kong and Macao.

　　Yacht go on road trip, as a new format of yacht tourism development, is "hot" again.

　　Since the development of yacht industry can drive the development of upstream and downstream service industries to a certain extent, the implementation plan proposes to carry out pilot work for the approval of temporary open waters for overseas yachts, explore the free travel of yachts from Qiong, Hong Kong and Macao, and solve the bottleneck problem that restricts the development of yacht industry in Hainan.

　　In this regard, the Ministry of Transport has studied the pilot project of decentralized approval, and approved the yacht free travel plan of Hong Kong, Macao and go on road trip in conjunction with national port inspection and inspection units such as the General Administration of Customs and the State Administration of Immigration, focusing on solving the problems of insufficient navigation waters and tight supervision faced by yachts from Hong Kong, Macao and overseas, so as to ensure that yachts can really get in and swim.

　　At present, there are 2 cruise terminals in Hainan, 8 yacht manufacturing enterprises registered in Hainan and 146 yacht sales and service enterprises. Twelve yacht marinas and 1,658 berths have been built and operated.

　　The insiders believe that in the next 10 to 15 years, China’s cruise yacht industry will develop rapidly, and Hainan will have greater achievements.

　　The CPC Central Committee and the State Council have given Hainan the position of "three districts and one center", one of which is the "National Major Strategic Service Guarantee Zone", and Hainan will play an indispensable guarantee function in the national strategies such as the "Belt and Road" construction and the development of integration of defense and civilian technologies.

　　As a "crossroads" at sea, the South China Sea is an important international maritime transport channel and a maritime hub connecting the Pacific Ocean, the Indian Ocean and the three continents of Asia, Africa and Europe. In recent years, with the strong support of the Ministry of Transport, the maritime search and rescue and emergency capacity building in the South China Sea has achieved remarkable results, which has played an important role in ensuring the safety of navigation and serving the construction and development of the South China Sea, but it is still difficult to meet the needs of maritime emergency support.

　　In view of the shortcomings of maritime search and rescue and emergency response capacity building in the South China Sea, the implementation plan proposes to improve the rescue support system in the South China Sea, with the aim of ensuring transportation and controlling safety risks, and improving the ability to prevent and respond to severe weather conditions such as typhoons, so as to serve the implementation of major national strategies.

　　Over the past year, Hainan Maritime Search and Rescue Center has initially established a maritime search and rescue cooperation mechanism with Hong Kong and Macao. The construction of South China Sea Maritime Rescue Base and South China Sea Rescue Force has been accelerating, and the maritime supervision base and Haikou Rescue Base have been completed and put into use. The construction of a 14,000-kilowatt large cruise rescue boat is accelerating; Maritime affairs, salvage and other related units have carried out four joint cruises of sea and air, including the waters south of Sanya and the waters west of the Greater Sanya Tourism Circle, and explored the establishment of a normalized three-dimensional cruise mode of sea and air that is suitable for the South China Sea.

　　Taking on the responsibility of the special zone, Hainan has been innovating constantly and moving towards the deep-water area of the national strategy of service guarantee.

　　In the field of service "Belt and Road"Hainan has accelerated the construction of the "Belt and Road" air-sea bridge. At present, 74 international (regional) air routes have been opened, and the number will be increased to about 100 in the next two years.

　　In the field of serving the "new channel of international trade by land and sea"Taking Yangpu Port as a pilot, Hainan will focus on building an international transit hub port facing Southeast Asia, and build a foreign trade route network that starts from Hainan and reaches major logistics nodes in Singapore and ASEAN, and then radiates to Southeast Asia, South Asia and the Middle East.

　　"Wan Li’s spring scenery is bright." With the support of the Ministry of Transport, Hainan will surely stand on the forefront and shine brilliantly.

　　CCTV News:In order to further enhance people’s awareness of network security, according to the deployment of "Net Net 2022" special action, the network police brigade of Zhong Kai High-tech Zone Branch of Huizhou Public Security Bureau and volunteers from Shuguang Community of Chen Jiang Street went deep into the community to carry out network security publicity activities to popularize network security knowledge and practical prevention skills for people in the area.

　　At the activity site, the Cyber Police Brigade and volunteers from Shuguang Community in Chen Jiang, by hanging propaganda banners, setting up propaganda desks and distributing publicity materials, publicized the police mainly around the common network traps, online fraud methods and personal information protection methods in real life, popularized the protection skills to the masses, patiently answered questions for the masses, and reminded them to enhance their awareness of self-protection and jointly created a harmonious, safe and stable network environment.

　　It is understood that this publicity campaign distributed more than 300 brochures and received more than 40 consultations from the masses, which effectively improved the public’s awareness of network security and basic protection skills and played a positive role in creating a safe, harmonious and stable network environment in the whole region. (General Desk reporter Yang Zhen)

1905 movie network news The brand-new drag racing action blockbuster (Baby Driver), produced by British WorkingTitle and directed by British genius director edgar wright, has been continuously praised since it landed in mainland cinemas. The word-of-mouth rating of the film on authoritative rating websites such as Time and Douban ranked first in the same period, and it was also praised by domestic authoritative media, film critics, KOL and other parties. Peach trees, poisonous Sir, independent fish, etc. are even more rare "three consecutive pushes", constantly giving Amway this film to the audience: "Cool! What a leg shake! Entertainment commercial films can also be made with personality and good looks. ""The anti-routine is full of creativity, and it is difficult to find the same kind when looking around the film history! "

As a typical British director, edgar wright is well-known for his wild imagination and personal interest in smuggling illicit goods. This new work "The God of Car Theft", which has been prepared for many years, has brought his dual attributes of "fans" and "fans" to the extreme. Under his carefully selected 30 leg-shaking BGM, he not only filmed the action scenes such as racing, parkour and gun battles, but also "hidden".

Let’s take a deep look at what "stalks" in the film are worth remembering:

[Salute/Line Stud]

1. Long-shot tribute to the previous work

Shortly after the opening of the film, the long shot of "Baby" buying coffee for gang members just pays tribute to director edgar wright’s own film "Shaun the Zombie". In "Shaun the Zombie", there is also a similar long opening shot, which shows the walking corpse of Shaun, the protagonist played by simon pegg, who goes to the supermarket to buy drinks.

2&3. My ears don’t work, so I bought the wrong mask.

In the second gang robbery in the movie, Brother Dao said at the meeting that he wanted to buy the mask of Michael Myers, the killer in the Moonlight Panic series. As a result, the pronunciation of "Michael" and "Mike" was confusing, and finally he bought the mask of Mike Myers, the main actor, which became a funny stalk and appeared in the scene where gangs spit on each other before the robbery.

4&5, and "Aunt Mei" are all supporting roles &hellip; &hellip;

In the movie, "Baby" and his adoptive father sat on the sofa and watched TV at night. When they changed channels, Meryl Streep, Brad Pitt and Disney’s Monster Company 2 appeared on TV. Moreover, these movie lines that flashed on TV also appeared in the following plot.

In other words, the "baby" is learning and using the movie lines that have appeared on TV. For example, in Monster Company 2, "We are a team, and nothing is more important than our friendship." This is what "Baby" said when she was threatened by Doug on a date with Deborah and had to compromise. Besides, the sentence "These children grow up so fast!" in "Love is Complicated" "Baby" took Brother Dao’s son to seek information at the post office, and the counter staff asked him how old his child was.

6. Fight Club &mdash; &mdash; Don’t let Buddy see blood.

When changing channels, Pete’s Fight Club appeared twice before and after, and Buddy also recited the lines of Fight Club when he first saw JD’s hat tattoo: "Will this work?" In fact, it indicates that Buddy’s ending will be blackened by love, suggesting that the baby and Buddy will finally fight to death.

Director edgar wright talked about the egg in an interview: "I heard that the matador had to stand on the ground to end the battle, so the’ baby’ had to get off at last." At the restaurant, Darlene also said to the bat, "Don’t let Buddy see red, or he will get out of hand." It also implies the egg of bullfighting. Director Edgar also pointed out that "when he finally tried to kill the baby, he was immersed in the red light."

7. Pay tribute to "Desperate Mandarin Duck"

The images of "Baby" and Deborah, Buddy and Darlene in the film all pay tribute to the classic "Bonnie and Clyde": Buddy and Darlene kill each other with heavy machine guns in the film; "Baby" and Deborah are trying to escape from the world. But at the end, "Baby" didn’t run away with Deborah, but chose the right path, creating a sunny and positive ending, instead of ending in tragedy like Buddy and Darlene’s "Bonnie and Clyde".

8. "Suspects don’t need to" pay tribute to Quentin

The film also pays tribute to the plot of Quentin’s "Reservoir Dogs", and the combination of people involved in the task changes every time. In "Auto Thief", director Edgar made three robberies in order to reflect this point, each time it was a brand-new combination of people, and the third time was definitely the most wonderful super combination.

9. Pay tribute to the release day

The director has mentioned many times that the movie The Driver, which was released on July 28th, 1978, was one of the sources of inspiration for Auto Thief. The release date of "Tiger’s Mouth Pulling Teeth" appeared twice in the film: once in the long shot of "baby" buying coffee, the release date was graffiti on the street wall; The other time was the number on the clothes of "Baby" after he went to prison (2871978). Because the director was British, he put the date before the month, not the American 7281978.

10. Pay tribute to the expression of sunglasses

In the film, the "baby" bowed his head to hold sunglasses and looked up to pay tribute to Kubrick’s clockwork orange. "Head down, eyes up, I call it Kubrick lens. Every time I want to shoot, I always say to Ansel: "clockwork orange" expression! " Director Edgar revealed in an interview.　

11. "The car is heavy enough to overturn the police car!"

At the gang meeting before the second robbery, "Bat" once questioned that the "baby" wearing headphones was not listening to Brother Dao at all, and then "baby" told the whole process without breathing. One of them said, "The car must be heavy enough in case the police car needs to be overturned." This is reflected in the final life-and-death confrontation with Buddy. The "baby" directly knocked over the police car stolen by Buddy.

[Musical Feelings Terrier]

12. Why is the hero called "baby"? Why is the movie called "Baby Driver"?

Director edgar wright has explained on many occasions that generally in criminal gangs, in order to hide their identity, everyone is commensurate with the code name, and "baby" is the youngest one in the gang, so this code name is more appropriate.

The selection of the classic lyric B-A-B-Y from the hit record Carla released by "Memphis Soul Queen" in 1966 as the chat material for "Baby" and "Deborah" also echoes this setting. Interested viewers will also find that "Baby" really picked up the vinyl record of this album. The real name "Miles" of "baby" is in harmony with his identity as an escape driver. As for the title "baby driver", it is a classic single of the same name from the famous folk group Simon&Garfunkel.

13. The 15-year origin of "shaking your legs for six minutes"

The most talked about in "Car Thief" is "shaking your legs for six minutes" at the beginning of the film. But in fact, as early as 15 years ago, director edgar wright tried this creative trick to direct MV for MintRoyale, an electronic band from Manchester, England. This song is called "Blue Song" and included in the band’s 2007 album "Pop is&hellip; "in. This MV, like Auto Thief, tells the story of robbing a bank. In this MV, Noel Fielding, a British comedian, plays a No.2 driver who loves music as much as "Baby".

14. "The King of Soul Songs" Jamie Foxx teased his friend Barbara.

Bartz, the crazy shit-stirring stick in the gang, is played by Jamie Foxx, the Oscar winner and musician. In the film of 2004, he perfectly restored ray charles, the father of American soul music, with a fake performance and called him the Oscar in one fell swoop. As an outstanding musician, he has been nominated for Grammy Awards many times.

Interestingly, although "Bartz" played by Jamie in "Car Thief" is dressed as a hip-hop musician, he pretends not to know who Barbra Streisand is &mdash; &mdash; And this "award-winning professional" who has many authoritative awards such as Oscar, Tony Award, Grammy Award, Emmy Award and Golden Globe Award is actually a good friend with Jamie in private.

15. It’s unlucky to listen to Knocking on the Door of Heaven before robbery &hellip; &hellip;

"Bartz" said of his former teammate: "We were safe, but he hung up because he was listening to Knockin’On Heaven. "Make the audience laugh. This song comes from Bob Dylan, a famous American folk singer. Yes, it is the one who won the Nobel Prize last year and almost didn’t receive it.

And the phrase "Bartz" is not groundless &mdash; &mdash; Edgar wright, the director, specially interviewed real robbers for filming this film and asked them what songs they would listen to before the "action". Besides this song, there are The End of the Road and Hotel California that can’t be listened to. Interestingly, one of the robbers named Joe Loya also made a guest appearance as a robbed bodyguard in the film.

[Friendship Guest Stud]

16. Jon Spencer started and finished.

At the beginning of the film, the music of the "shake your legs for six minutes" racing scene comes from Jon Spencer Blues Disclosure’s "Bellbuttoms". The last line (not narration) before the end of the whole film is also from the lead singer Jon Spencer.

Yes, he is the one who said to the "baby", "Here’s a letter for you, boy!" The prison guard. The director said that he hoped to finish what he started, so he chose this song and wanted to end it with his voice.

17. red hot chili peppers legendary bassist "Brother Flea" has been addicted to drama again.

Eddie in the second wave of robbery gangs in the film doesn’t have much time to play, but he actually plays a lot. He is the legendary bass player "Flea" in red hot chili peppers. In addition to being a musician, he also likes to guest play some small roles in movies, such as Needles in the series and Jake, the thinking worker in the series. Coincidentally, there is also a character named "Doc" in the first part of Back to the Future, and "Griff" in the second part, which just corresponds to the code names of Kevin Spacey and jon bernthal in Auto Thief.

18. Baby’s mother is really a singer.

The most sensational of "Auto Thief" OST is "Easy". Besides the original version of Lionel Richie (yes, the one who sang "Say You, Say Me"), the film also included a cover version of American female singer Sky Ferreira. In the film, her version of the tape is not only regarded as a relic of the "baby" mother, but also played the "baby" mother herself.

19&20, these guys shouted Banana! The "underworld" is actually a musician.

The leader of the short white arms dealer (black policeman) who was killed by Bartz was played by the famous film musician paul williams. He has been nominated for the best original song at the Academy Awards for many times, and in 1977, he won both an Oscar and a Grammy for the theme song of his lyrics "Evergreen". Coincidentally, the singer and composer of this award-winning work is barbra streisand, whom Jamie Foxx "teased" in "Car Thief".

Besides, when Brother Dao met Baby in a fancy restaurant, the two gangsters around him were also famous hip-hop musicians, namely Big Boi and Killer Mike. The two have released a single together, and the former is a member of Outkast, a famous Atlanta hip-hop group, and one of the creators of Chase Me, the theme song of Auto Thief.

21, "adoptive father" seiyuu turned out to be the director’s idol.

The actor named "Baby" adoptive father is C.J. Jones. He is the first African-American deaf-mute comedian to play a movie on the big screen in Hollywood. He is really deaf-mute, and he also uses real sign language when playing. Many viewers were moved by their father and son’s previous affection.

As mentioned above, The Driver is one of the sources of inspiration for this film. In addition to paying tribute to the release date of the film, Edgar even wanted to let the film director walter hill play a role directly, but unfortunately it was not done because of the schedule. However, in the final trial scene of the film, the legendary director gave his voice by translating for the "baby" adoptive father and acted as the "seiyuu" of the second adoptive father.

22. The "Haier Brothers" in Atlanta came out again.

When the "baby" shot and wounded Buddy in the restaurant, he escaped with Deborah and hijacked a red sports car. The two young people in the sports car who were hip-hop in America were online celebrity twins, who were famous in the United States. The "yellow and violent" brothers often appeared in movies, magazine covers and the most popular MV of traprapper.

[There is no one who controls obsessive-compulsive disorder in this detail &hellip; &hellip; 】

23. The lyrics go over a wall, and spades turn into hearts in seconds.

On the way of "Baby" buying coffee and dancing, every lyric of BGM’s Harlem Shuffle appeared in various forms where he passed by. The graffiti on the background wall was originally a spade, but after the "baby" saw his favorite sister, the spade immediately turned into a heart. According to foreign media reports, this graffiti was specially drawn by the director who hired local artist Peter Ferrari.

24, listening to songs must be put from the beginning, sunglasses just can’t be taken off.

The image of "baby" sunglasses and headphones is not only cool, but also many people want to isolate themselves from the outside world.The shadow of the world’s urban civilization. For example, be sure to put the songs in the iPod from the beginning, and step on it well before driving; For example, if sunglasses are knocked out, they should be replaced immediately. The setting of sunglasses and headphones just reveals his obsessive-compulsive paranoia in his heart, and sometimes shows a little black humor, which is probably one of the reasons why the director can be sought after by fans all over the world.

25. There is a story behind the robbers’ tattoos.

If you look closely, you will find that the tattoos on the necks of several criminals in the gang and their character characteristics can always form interesting ones.Correspondence. For example, "her" and "his" tattooed by "Bonnie and Clyde" Buddy and Darlene respectively imply their inseparable love relationship; For example, Bartz really has several "bats" tattooed on his neck; For example, Lanny Joon, a Korean-born actor, initially tattooed a grandiose "HATE" (hatred). In order to expand business, the letter "E" was forcibly erased and changed to "HAT" (hat), but in fact "JD" (John Doe) means "Anonymous" in English, and this role soon got a lunch.

[which cars have the protagonist aura? 】

In the whole film, at least 34 different models of cars can be seen. The most interesting thing is that because the director specially interviewed the real robbers before, he knew that the cars they used to commit crimes would never be luxury cars like those in "Speed and Passion", but family cars with low visibility and superior performance, such as Subaru Xiaohong, the favorite car of "Baby", and Escalade, Yukon and Chevrolet Avalanche. The luxury car in the heroine Deborah’s heart is a retro classic car.

26. Subaru second-generation impreza WRX

The highlight of the film is the coquettish and domineering red Subaru in the opening six minutes. But before shooting, thisThe Subaru was changed from a full-time four-wheel drive to a rear-wheel drive, and the extremely difficult U-Turn and the continuous drift of more than 180 degrees in the film were completed. The basin friends who love cars should not blindly imitate it!

27, the second generation Chevrolet K5 Blazer

At the end of the film, "Crash Wars", "Baby" drives a second-generation K5 Blazer and Buddy produced in 1980s.Dodge Charger police cars fought each other, and finally Buddy’s car was pushed off the patio.

28, 1959 Chevrolet ImpalaConvertible.

Deborah’s ideal "luxury car" is such an old guy from the 1950s, which shows that this girl is still very tasteful. At the end of the film, as soon as the "baby" released on bail walked out of the prison gate, it was a good ending to see a beautiful woman and a beautiful car greeted him.

29. User-made GTA5 video God restores "shake your legs for six minutes"

The opening "Shake Your Legs for Six Minutes" of "Car Thief" attracted the attention of many grand theft auto v players. A foreign player named Domestic Mango on Youtube also used this game to make another 4-minute and 37-second short film, which accurately restored the most important scene of diversion, drift and sudden braking in the six-minute paragraph, and made a sincere tribute to this brand-new blockbuster that paid tribute to many classic blockbusters.

[Atlanta Real Landmark Test]

The whole film was filmed in Atlanta in the eastern United States. In order to show more realism, the director added many local landmarks and brands, and the details were embarrassing.

30. "Criminal Records"

When "Baby" first heard Deborah humming "B-A-B-Y" in the restaurant, she immediately bought the record and went home to sing and dance happily. The place where the "baby" in the film buys records is this old-school vinyl record store named Criminal Records in Atlanta, USA.

31. Bacchanalia Restaurant.

Opened in 1993, it is one of the most acclaimed high-end restaurants in Atlanta. In the film, Darlene and Buddy mentioned this restaurant when they kissed in the elevator, and then in the laundry room, "Baby" also invited Deborah to this restaurant for a date, calling it "the best place to drink and eat in the city."

32. Sweet Auburn apartment of "Baby"

The apartment where the fictional "baby" lives in the movie is actually located in the historic district of Sweet Auburn, which is near the historical site of Martin Luther King, and was once an important political, economic and cultural center for African Americans in the first half of the 20th century. We can imagine what the "baby" who lives here does every day. Maybe he will visit the town market here, where there are the best meat products in Atlanta, bakeries, bookstores, pharmacies and the most popular restaurants in 11 cities.

33. Octane Coffee

Before every important meeting of the robbery gang, "Baby" always goes to this store to buy coffee. The name "Octane" is perfect for a fast-paced car chase movie.

34. Goodfellas Pizza

When "Baby" tried to get rid of his life as a runaway driver who robbed a bank, he began to work as a delivery boy at Goodfellas Pizza, hoping to bring joy to others with his own fast driving skills.

35. Romantic road trip to the extreme: ROUTE 66 (Route 66)

Deborah described this passage when she first met Baby: "I want to drive a vintage luxury car that I can’t afford, and there is no destination all the way west, only music and roads." What a romantic thought (mood). My little sister should be an old driver, too.
　

On the wall of the restaurant where Deborah works, the most famous brand of route 66 in the United States hangs. This most famous "Mother Road" has witnessed American history since the first half of the 20th century, from Chicago across the land of the United States to Los Angeles, and it is also the location for movies such as movies and movies.
　

In fact, before the British director wrote the script, he gave himself a trip to road trip across the United States. He drove from new york to L.A. by himself, and I believe he also incorporated many special feelings in his journey at that time. Therefore, at the end of the "anti-climax" of the movie, the pair of desperate mandarin ducks staged a romantic elopement. They may really want to drive this scenic avenue from Highway 20, but unfortunately it still backfired. After Baby was arrested, Deborah mailed him a postcard, including a mural from Bo’s Diner in route 66. In the end, on the day when Baby was released from prison, Deborah was driving a vintage car. Perhaps this road trip symbolizing freedom and dreams will finally begin.

Isn’t it romantic? There are too many connotations to see? Edgar wright, the director, ingeniously combined music with racing and the anti-type and anti-routine of action elements. How can you enjoy it with two brushes and three brushes? "Auto Thief" is being shown in China. If you miss it, your summer will be incomplete!

　　Photo courtesy of vision china

　　Gene therapy can "correct" the mutant genes that cause diseases, thus bringing hope for the patients suffering from congenital genetic diseases. But recently, in a clinical trial of gene therapy conducted by a biotechnology company in the United States, two children who participated in the trial died unfortunately.

　　After decades of twists and turns, gene therapy has brought new hope for the treatment of major human diseases, especially many genetic defects. However, gene therapy has recently suffered setbacks.

　　Recently, an American biotechnology company (Audentes Therapeutics) issued a letter saying that among the 17 children with neuromuscular rare diseases who participated in the company’s "AT132" gene therapy, two children died after receiving high-dose gene therapy.

　　The key research of this gene therapy began in 2017, aiming at treating a fatal disease caused by a single gene mutation &mdash; &mdash; X chromosome linked myotubular myopathy. The treatment was originally intended to be submitted this year and expected to be approved by the US Food and Drug Administration by the end of the year, but the plan has now been shelved.

　　Some children died while receiving gene therapy 20 years ago. What are the differences between the gene therapy at that time and this gene therapy? After decades of development, what improvements have been made in gene therapy and what problems are still facing? In this regard, the Science and Technology Daily reporter interviewed relevant experts.

　　"What is missing makes up for what is missing" and "corrects" mutated genes.

　　In human body, there is a gene named "MTM1", which is used for the development and maintenance of muscle cells by expressing a protein called "Myocardin". X chromosome linked myotubular myopathy is caused by the mutation of "MTM1" gene.

　　X chromosome linked myotubular myopathy mainly affects skeletal muscle, and its symptoms are muscle weakness and hypotonia. Muscle lesions will damage the patient’s ability to sit, stand and walk, even cause difficulty in eating and breathing, and may also lead to ophthalmoplegia, facial muscle weakness and muscle reflex disappearance.

　　At present, the main treatments for the disease include physical therapy and the use of support equipment such as ventilators. Studies have shown that the chemical drug "pyridostigmine" may be beneficial to improve clinical symptoms, but no formal clinical trial has been carried out. Generally speaking, there is no effective treatment for this disease at present.

　　To this end, researchers began to explore the use of gene therapy to "correct" mutated genes. "Based on &lsquo; What is missing is what is needed &rsquo; The gene therapy uses adeno-associated virus (AAV) as a vector to transfer normal &lsquo; MTM1&rsquo; Genes are introduced into muscle cells to produce myotubes with normal function, thus repairing the function of damaged muscle cells. " Qiu Zilong, a researcher at the Center for Excellence and Innovation in Brain Intelligence of China Academy of Sciences, said that this is a "permanent cure" treatment method, and under ideal conditions, it can even achieve "one treatment and lifelong benefit".

　　How to realize this "correction" process? "The whole process and &lsquo; Drip &rsquo; Very similar. " Qiu Zilong pointed out that the researchers injected the adeno-associated virus loaded with normal "MTM1" gene into the patient’s blood, delivered the adeno-associated virus vector to muscle cells through blood circulation, and produced "myosin protein" with normal function in it.

　　Before these children participated in clinical trials, the gene therapy had been pre-clinical studied, including verifying the safety and effectiveness of the therapy in cell and mouse disease models cultured in vitro, and the therapy was generally safe.

　　But in order to improve the therapeutic effect, the researchers tested a higher dose of gene therapy. "High doses are particularly important for neuromuscular diseases, because more copies of genes are needed to reach the targeted tissues through blood circulation." Dr. Cheng Cheng, from the School of Bioengineering, East China University of Science and Technology, said that the dose used in this gene research is the highest dose in gene therapy: 300 trillion copies of genome per kilogram of body weight.

　　The upgraded transmission carrier is safer.

　　In recent years, gene therapy has developed rapidly. The event that the "brake button" was also pressed occurred in 1999. An 18-year-old American patient named Jesse Kissinger died in a clinical trial of gene therapy with adenovirus as the carrier.

　　At that time, researchers used adenovirus as a vector to insert genes into patients’ cells to replace those parts that were lost or dysfunctional and caused diseases. A few days later, Jesse died of multiple organ failure due to severe immune response, which poured cold water on those who were initially optimistic about gene therapy.

　　After the tragedy of Jesse Kissinger’s death due to gene therapy, the researchers reduced the size of the laboratory and focused on finding safer virus vectors. Finally, they discovered and promoted the use of adeno-associated viruses.

　　Adeno-associated virus (AAV) is a kind of single-stranded DNA deficient virus with the simplest structure found at present. Adeno-associated virus gene therapy uses adeno-associated virus as a carrier to deliver therapeutic genes to specific tissues and organs, and these therapeutic genes stably exist and express in the form of free bodies in these non-splinter cell, thus effectively treating monogenic genetic diseases.

　　At present, adeno-associated virus (AAV) is the mainstream carrier platform for gene therapy, and there are also adenovirus and lentivirus gene therapy. Qiu Zilong pointed out that compared with adenovirus, adeno-associated virus vector has the advantages of high safety, low immunogenicity, longer curative effect and easy modification, and the newly discovered adeno-associated viruses such as AAV8 and AAV9 are 10-mdash stronger than adenovirus in transferring genes into cells. A hundred times. Lentiviruses, on the other hand, have the characteristics of randomly integrating genomes, and there is a potential risk of destroying normal gene functions.

　　In addition to the rare diseases caused by single gene mutation reported in this report, gene therapy is also used to treat Parkinson’s disease, Alzheimer’s disease, cancer and other complex diseases at home and abroad. At present, about 42 companies and nearly 100 drug research and development projects use adeno-associated virus vectors for gene therapy. In this fatal accident, the carrier used by researchers for gene therapy was AAV8.

　　Too high dose is easy to produce toxic and side effects.

　　Regarding the insecurity of gene therapy, Cheng Cheng believes that in the case of "AT132" gene therapy, the cause of children’s death may be that they received an excessive dose of adeno-associated virus intravenous injection, which produced a large number of antibodies against adeno-associated virus. The combination of virus and antibody can further activate complement pathway or innate immune response, thus causing strong toxic and side effects.

　　"Another kind of insecurity is the dislocation expression of normal genes." Cheng Cheng took the gene therapy of spinal muscular atrophy "Zolgensma" as an example, saying that intravenous injection would lead to excessive accumulation of normal genes carried by "Zolgensma" in the liver, but this gene did not play a role in the liver, which triggered a common hepatotoxicity after treatment, which was manifested by the increase of transaminase.

　　As early as a few years ago, james wilson, an American scientist who was a pioneer in gene therapy and one of the developers of adeno-associated virus, expressed concern about the high-dose vector used in gene therapy. In February 2018, the Wilson team published a paper saying that after high-dose injection of adeno-associated virus, it caused serious toxic reactions in rhesus monkeys and piglets, and one rhesus monkey had to be euthanized due to liver failure. To this end, Wilson called on researchers to carefully monitor similar toxic effects during gene therapy.

　　Wilson’s collaborator, Professor Gao Guangping of the Massachusetts Institute of Technology, once expressed similar views. In an interview in 2019, he expressed concern that the rapid development of this field would make people less cautious and might make Jesse Kissinger happen again.

　　"Scientific and technological progress will experience setbacks." Qiu Zilong said that although this high-dose gene therapy caused the death of the patient, the effectiveness of gene therapy cannot be denied. In the face of the lack of effective treatment for rare diseases with single gene, gene therapy has indeed brought hope to many patients and their families. At present, there are still many shortcomings in gene therapy, which needs continuous improvement and perfection by experts and scholars in the field to make it safer and more effective, and should not be abandoned because of choking.

　　In promoting the development of gene therapy, Qiu Zilong suggested that it is necessary to constantly transform to obtain new types of adeno-associated viruses with special tissue affinity, reduce the immune response of the human body after injection, achieve more accurate delivery of normal genes, and further reduce toxic and side effects; At the same time, research and develop better gene regulatory elements, so that normal genes delivered to patients can produce functional proteins in a timely and appropriate way.

　　Cheng Cheng also suggested that the production and purification process of adeno-associated virus can be further optimized to reduce impurities in the virus and improve its purity. Choose a better carrier delivery mode, such as intrathecal injection or intraventricular injection for diseases of nervous system.

　　[car home Information] The new model 2.4LX of Guangzhou Honda’s eighth-generation Accord went on sale today.Pricing is 219,800 yuan.Enjoy the warranty policy of "three years or 100,000 kilometers for the whole vehicle". At present, the car in Beijing has arrived at the store and fully accepted the reservation.

　　The launch of the new eight-generation Accord 2.4LX enriches the Accord’s product line, reducing the price range of the 2.4L model by another 10,000 yuan, and the price of 219,800 yuan is the same as the top model of the Accord 2.0L. Appearance, the new model has not changed, only some configurations have been adjusted.

　　Compared with the original Accord 2.4L, the 2.4LX model has three reductions, namely, xenon headlights are cancelled, halogen bulbs are used instead, headlight cleaning device is cancelled, and the rear seat air outlet is reduced.

　　In 2008, the Eight-Generation Accord sold a total of 170,517 vehicles, ranking first in the medium-sized car market. The launch of the new model has enhanced the fighting capacity of the Eight-Generation Accord in the auto market in 2009. Although some of the reduction has reduced some luxury feelings, the decline in the price is the most affordable for consumers.

　● Manufacturer information

　　On January 12, 2009, Guangzhou Honda Automobile Co., Ltd. announced that it would launch a brand-new model 2.4 LX of the eighth generation Accord sedan, with the manufacturer’s guide price of 219,800 yuan, and enjoy the warranty policy of "three years or 100,000 kilometers for the whole vehicle". It is understood that this new car has arrived in Guangzhou Honda national special sales service store one after another, and fully accepted the reservation, adding another fire to the auto market on the eve of the Spring Festival.

　　Experts in the industry commented that just after New Year’s Day in 2009, the eighth generation Accord took the lead and fired the "first shot" in the medium-sized car market, which not only showed its confidence in defending the 2009 sales champion, but also predicted that the competition in the automobile market this year will be more intense and more exciting.

● Perfect start, consolidating the leading position in the 2.4L market segment.

　　As the "opening work" of the eighth-generation Accord sedan in 2009, the eighth-generation Accord 2.4LX continues to adhere to the concept of "B++".In terms of body size, the length, width and height reach 4945×1845×1480mm and the wheelbase reaches 2800mm respectively. The size and space are beyond all models in the same class, which well meets the customer’s requirements for space and comfort. The interior design fully shows the high-grade and fashionable style.

　　2.4 LX is equipped with a new DOHC inline four-cylinder engine and Honda’s famous i-VTEC (Intelligent Variable Valve Timing and Lift Electronic Control) system. The engine power reaches 180 HP and the torque reaches 225N·m, which is at the leading level in the 2.4L subdivision level. While achieving strong power, this car also maintains the consistent fuel-saving advantage of Honda products. The constant-speed fuel consumption of 90km/h is 6.5L/100km, which is the lowest in the same class, and the emission reaches the national IV standard.

　　The eighth generation Accord 2.4LX adopts a brand-new low center of gravity platform, and realizes a smooth chassis layout through a well-designed double wishbone front suspension and a new in-wheel multi-link rear suspension. The torsional stiffness of the car body is increased by 20% compared with the previous generation, and the stiffness of the suspension fulcrum is increased by 36%, giving people a stable and comfortable driving experience. Equipped with a new type of VGR steering system, which is generally only used in high-end cars, the vehicle has high directional stability at high speed, and good maneuverability and precision at low speed, which brings more driving pleasure.

　　In terms of safety technology and configuration, the eighth generation Accord 2.4 LX adopts Honda’s latest "Advanced Compatibility Design (ACE)" body structure technology, which improves the buffering effect of impact energy in various possible collision accidents. The amount of high-strength steel is also greatly increased, ensuring the firmness of the passenger compartment. The advanced energy-absorbing design of pedestrian protection head represents the future direction of automobile development.

　　The eighth generation Accord 2.4 LX is equipped with a complete six-in-one electronic security systems, including ABS anti-lock braking system, EBD electronic braking force distribution system, TCS traction control system, BA braking force auxiliary system, SC anti-skid system and VSA vehicle stability auxiliary system, which greatly improves the driving safety. Passive safety facilities include two-stage ignition front airbag, front seat side airbag, and active head restraint system that can reduce neck injury when the rear of the vehicle is collided, and cooperate with OPDS (occupant sitting posture perception) system to minimize the degree of injury when an accident occurs.

　　On April 20th, 2008, the first batch of C-NCAP crash test results of China Automotive Technology and Research Center in 2008 were released. The eighth generation Accord achieved the highest score of C-NCAP crash in the domestic car market with a total score of 50.3, becoming the only car that has won the super five-star evaluation so far. Experts from C-NCAP evaluated the safety performance of the Eighth Accord as "nearly perfect".

　　In terms of comfort and convenience, the eighth generation Accord 2.4 LX is equipped with electric sunroof, 4-direction adjustable electric folding exterior rearview mirror, SVC (Speed Sensing Sound Compensation System), cruise control system, dual-zone independent control automatic air conditioner and intelligent access system.

　　The listing of the eighth generation Accord 2.4LX makes the eighth generation Accord form four series of 2.4EXLNavi, 2.4EXNavi,2.4EX and 2.4LX at the 2.4L level, which is conducive to further consolidating its leading position in this market segment. At this point, the eighth generation Accord sedan has successively launched three gold displacement combinations of 2.0L, 2.4L and 3.5L, with a total of eight new models with different configurations, with accurate parking spaces in the price range of 181,800-339,800 yuan, thus building the most powerful product matrix in the medium-sized sedan market and providing consumers with the richest choices.

● Glorious coronation, the eighth generation Accord is "the strongest in history"

　　In 2008, affected by the aggravation of the US financial crisis and the slowdown of domestic macroeconomic growth, China’s automobile market has undergone considerable adjustment, and the medium-sized car market, which is regarded as the vane of the automobile market, bears the brunt. In the face of various unfavorable factors, the eighth generation Accord sedan went against the trend and became popular all the way, winning the annual sales champion of medium-sized cars with an impressive performance of 170,517 cars.

　　With the support and trust of customers and all walks of life, the eighth generation Accord was highly praised and affirmed in the annual model selection of major authoritative media at the end of 2008: Car Magazine’s 2009 car of the year, Strong Media Alliance, 2008 China Car Billboard, and so on. According to incomplete statistics, at present, the eighth generation Accord has won the annual model selection award issued by more than 30 authoritative media.

　　On January 6, 2008, when the eighth generation Accord sedan was officially launched, Guangzhou Honda said that the eighth generation Accord should set up four coordinates for the market: trend coordinates, technical coordinates, value coordinates and service coordinates. With the quality of leading peers, "B++" technology, "C-class" service comparable to imported luxury cars and the brand value brought by it, the eighth generation Accord sedan has not only been highly recognized by consumers, but also by the media and all walks of life. The sales volume of 170,000 vehicles, more than 30 annual model awards and the praise of countless consumers all prove the fact that the eighth generation Accord has become a veritable new coordinate in the medium-sized car market.

　　"There is no first in mind, only consistency", which is the long-term commitment of Accord brand to consumers. The person in charge of Guangzhou Honda said that sales volume and honor are only a result. In contrast, Guangzhou Honda pays more attention to the process of providing consumers with high-quality products and services. As long as we conscientiously implement the consumer-centered business philosophy and strive to do the best in every detail of products and services, no matter how the automobile market changes in 2009, the eighth generation Accord will continue to lead the trend of the medium-sized car market and climb the sales peak again!

　　Overview of parameter configuration table:

Special feature of 1905 film network Shortly after the opening of the year, the film market became more and more lively, and the pattern of Spring Festival stalls was gradually formed.

After the file was finalized, the new work was without warning and took the lead in airborne years later; Join hands again and pick up the stick quickly; It is a climax to lose 100 pounds for the play; With the new work, it has been "killed" into the Spring Festival file for three consecutive years.

It’s only one month before the opening date of the Spring Festival in 2024 (February 10th), and whether there will be any films in the future has not been decided, but the current situation of "5 +1" (5 live-action movies+1 animated film) is the same as last year’s "4+2" battle, while the situation of live-action movies is the same as the "5+3" of the Spring Festival in 2022.

Besides Han Yan, Han Han, Jia Ling and Zhang Yimou have all hit the Spring Festival stalls more than once.

There is no need to repeat the box office of over 5 billion; From 600 million to 4.5 billion in Zhang Yimou, one is more stable than the other; Han Han scored over 1.7 billion and became a classic; The record of 2.2 billion has become the highest record of Ning Hao’s independent directed works.

Once upon a time, comedy movies seemed to be the core content of New Year’s Eve and Spring Festival files. With the arrival of other universal themes in Spring Festival files, comedy is no longer a special offer for Spring Festival files.

More than that, since the beginning of 2024, from the comedy dark horse in the beginning of the year to the "clash of the titans" in the Spring Festival.

Or, comedy will surprise the film market in 2024!

"Xi" in the Spring Festival file

From the six films currently scheduled for the Spring Festival, it can be seen that except the theme/genre of Viva La Vida by Han Yan is "plot, love, family", the other five films have more or less strengthened the "comedy" attribute.

The Movie Emperor, which was announced at the end of last year to be changed to the Spring Festival, has always highlighted the concept of "elegant comedy" and showed the audience all kinds of strange stories in the entertainment circle with a very playful style. At present, the multi-dimensional release of video materials, combined with the intertextuality of starring images inside and outside the play, also makes the film feel full of joy during the viewing process.

Not only the content of the film, but the label "Ning Hao" alone makes the comedy elements sublimate. Since his big-screen debut, he has started his own "Crazy Comedy", and subsequent films have laid the commercial value of Ning Hao’s comedies.

Only compared with other comedians, Andy Lau’s comedies are more driven by the plot and bring "laughter". The latest comedy work is a movie, which is also driven by the plot, and the self-response inside and outside the play is interesting.

The biggest attraction of Han Han’s Pegasus 2 is to cooperate with Shen Teng again.

As early as the writer’s time, Han Han was good at using words to show cold humor. After the transformation of the director’s identity, there are many such golden sentences in the film, which has become a unique "cold style." Especially after the polishing of four films, his comedy characteristics have become a symbol.

Actor Shen Teng is also a "comedian" with a very personal comedy style. In Shen Teng’s past works, his comedies always amuse the audience with exaggerated expressions and actions and nonsense language. Moreover, Shen Teng has a unique comedy personality because of his perennial personality. At the same time, the little people he interprets more can resonate with the audience.

In "Pegasus 2", his role continues the "timid" temperament in the previous work, and their unique comedy styles are further combined. With the addition of comedians such as "","Pegasus 2" is quite interesting.

Jia Ling YOLO must be one of the most watched movies at present.

The term "Jia Ling lost 100 Jin" frequently appeared in hot search topics, but what YOLO wanted to express was always more than that, and more was to return to himself. In this work, the cooperation of Jia Ling,, and, on the contrary, makes the comedy have a certain visibility.

Whether it’s Jia Ling’s sketches before Zhang Xiaofei, or the film Hi, Mom co-produced by two people, or Lei Jiayin and Zhang Xiaofei co-produced, the three-person comedy always uses accidents to drive details, and the core is a softer emotional side.

Especially, Jia Ling, as a female filmmaker, can always handle comedies subtly with great accuracy, and be close to life and emotions from a female perspective. From Hi, Mom’s yearning for her mother to YOLO’s self-realization, perhaps she will bring us another emotional resonance with tears in her laughter.

Viva La Vida directed by Han Yan became the only non-comedy film in this year’s Spring Festival. Even when the film was finalized, many netizens had doubts. Why do you want to watch a work with a certain sad background during the Spring Festival?

Part of the film is based on the documentary report "The most utilitarian marriage transaction, the most emotional eternal agreement". This story is not a tragic ending, and it may be able to feed you a valium pill.

Whether directed by Han Yan or produced by a producer, comedy is always a plus item of these works, especially the opening work of the trilogy of life, which is a proper comedy film.

At the same time, as one of the leading actors, most of the previous screen images were created by comedians. Perhaps his performance can also provide a certain bonus for the comedy performance of the film.

How to "smile"

Undoubtedly, the Spring Festival in 2024 will be a "multi-strong hegemony" situation.For the audience, they can walk into the cinema through the atmosphere of the Spring Festival, feel these wonderful films and enjoy the joy of the whole family.

As early as 2018, the Spring Festival was still a comedy feast. From then on, these classic comedy creators always produced a film for the audience. Until the military theme Operation Red Sea appeared in the Spring Festival file, the pattern of "comedy is king" seemed to be broken, and the Spring Festival file was no longer limited to comedies or special effects blockbusters.

It was that year that Operation Red Sea, as the only non-comedy film in the Spring Festival, found a breakthrough, and even went crazy after the festival, surpassing the films that were far ahead in the pre-sale stage.

The following year, the single theme type continued. During the schedule, The Wandering Earth countered the works such as Crazy Alien and Flying Life in one fell swoop and won the box office championship.

After two consecutive years of market performance, the Spring Festival stalls have been completely opened and entered the 2.0 era of heroes by quality. In the schedule, the particularity of the theme type is more likely to be concerned.

The theme type is no longer limited by the Spring Festival schedule, but it cannot be ignored that the celebration of the Spring Festival still allows the audience to have a special filter for this schedule. Even those who flaunt the comedy type are still criticized for their tragic ending on the first day of release, and eventually become regrets.

In the Spring Festival file in 2023, animated films were also relatively melancholy in temperament, and their performance was mediocre during the file period. It was not until after the screening that they achieved a turnaround against the wind by virtue of word of mouth and topics.

Although the choice of theme types of films becomes diversified, high-quality comedies are still the first choice for the audience.

In the Spring Festival of 2022, as the only pure comedy film, the film eventually became a dark horse; In 2023, "Man Jiang Hong", the main genre of "comedy suspense", still maintained a strong situation under the gathering of many types of themes, and won the box office championship.

Nowadays, at the time when Toshitabe comedies are assembled for the Spring Festival in 2024, it is the most crucial thing for each film to attract attention with its own particularity in the early publicity and get the audience’s "first ticket" in the pre-sale stage.

We expect these works to be recognized by the audience with high quality, win long-term opportunities, and gather gas together for the opening year of 2024!

　　[Illustration of New Cars in car home] At the Chengdu Auto Show in 2023, Equation Leopard brought the newly unveiled (|) concept car, which will reveal the design information of the future Leopard 8 production car. Equation Leopard has previously announced the "583 Hard Family" plan, which includes three models: Leopard 5, Leopard 8 and Leopard 3. Let’s take a real shot at the auto show to take the lead in seeing what the appearance of Leopard 8 is!

　　Equation Leopard 8 concept car adopts founder design language, and uses a lot of sci-fi design elements in details, which is very Cyberpunk style. The front grille of the Leopard 8 concept car is similar to that of the Leopard 5, and the rectangular grille is integrated with the headlights, further enhancing the visual width of the front face.

　　Leopard 8 concept car headlights and Leopard 5 current matrix headlights come down in one continuous line in design concept. The white light guide bar inside the lamp cavity forms a C-shape, and the light guide bar wraps two LED lamp caps, showing a feeling of eyes staring. The headlight cavity of the concept car should be further refined in design to further increase the design elements inside the cavity.

　　The big white equation Leopard Logo is located in the center of the black rectangular grille, which is very conspicuous and highlights the brand confidence. The upper and lower edges of the rectangular grille are provided with white light guide bars, which are connected with the light guide bars of the headlights to form a white annular through daytime running light at the front of the car.

　　The front bumper is decorated with a large silver plaque, just like a metal bumper, which adds the off-road momentum of the front face. However, as the concept car of Leopard 8, practical winches and trailer hooks did not appear on the exhibition car.

　　Vision comes to the side, and the roof of the Leopard 8 concept car integrates a silver luggage rack, which is unique in shape; The design of hidden A-pillar, B-pillar and D-pillar is adopted, and the C-pillar is in a silver trapezoidal shape, which looks a bit like the design of a yacht. The horizontal shoulder line above the front and rear wheel arches has a horizontal waistline on the door, and the shoulder line and waistline are staggered, which enhances the design layering of the side of the car body.

　　Hidden door handles and electronic exterior rearview mirrors are the trend configuration, and the Leopard 8 concept car is also equipped. I wonder if this electronic exterior rearview mirror configuration will appear on the production car? It is worth looking forward to.

　　The side skirt of the concept car is decorated with a huge trapezoidal guard, which looks very handsome. I wonder if the production car will be made into an electric pedal? As can be seen from the wheel arch position, the jumping travel space of the wheels of the Leopard 8 concept car is very large, which further improves the passability of the vehicle.

　　The petal-shaped rim style, combined with the deep depression design in the center of the rim, has a very good visual effect. From the picture, the concept car is equipped with AT all-terrain tires, which can take into account urban roads and off-road conditions.

　　The design of the rear of the concept car is still wide and square, and the external spare tire is placed between a huge lateral bracket and the tailgate, which is very futuristic in design, but I don’t know if this design will be adopted in the production car.

　　The taillight adopts a vertical rectangular outline with a white vertical LED light bar in the center, which should be the daytime running light at the tail. The overall shape of the red light guide bar is a bit like a grip, showing a strong sense of strength.

● Full text summary:

　　The general appearance of the Leopard 8 concept car is quite distinctive, and there are not many features that are difficult to mass-produce. I believe that the design of the mass-produced car will have a high similarity with the concept car. At present, the interior of Leopard 8 is still kept secret, and the technical configuration information such as power system has not been released. We in car home will continue to pay attention to the latest information of this car. (Text/car home Chang Qinglin)