Original Wuyuan Li Na and other SIFIC infection horizons　

Author: Wu Yuan Li Na Jin Wenting Ma Yuyan

Review: Hu Bijie and Pan Jue

First, a brief introduction to medical history

Male, 63 years old, from Shanghai, was admitted to the Infectious Diseases Department of Zhongshan Hospital for the second time on November 23, 2022.

Chief complaint: indwelling catheterization with repeated urine color turbidity for 2 months and then 8 days.

Current medical history:

On September 19, 2022, I went to a hospital in Shanghai for fatigue, anorexia and dysuria. WBC 10.12×10 9/L, N 87.6%, Hb 53g/L, hsCRP 135.22mg/L, ESR 62mm/H, albumin 30.1g/L, Scr 589μmol/L, K 2 were examined. Urine routine: WBC 3892/ul, occult blood 3+/RBC 5579/ul, protein 2+; Chest CT: bilateral pleural effusion, partial atelectasis of lower lobe of both lungs; Abdominal pelvic CT: Bilateral middle and upper ureteral dilatation and renal pelvis and calyceal dilatation, the patch in the right part of calyceal is slightly high density, the bladder wall is thickened, there is a little flocculent blur around the left renal fat sac and ileocecal part, and there is a little effusion in the pelvic cavity. A large amount of turbid urine was drained by indwelling catheter. Urine culture showed that Klebsiella pneumoniae was positive. Considering urinary tract infection, acute kidney injury, hypokalemia and severe anemia, patients were given symptomatic support treatment such as anti-infection, bladder irrigation, antioxidation, potassium supplementation and blood transfusion. The symptoms of patients improved and the urine was slightly clarified. 10-18 Review urine routine: WBC3+, RBC3+, protein 1+, SCR 263 μ mol/L.

I was admitted to our department on October 19, 2022. Blood routine: WBC 5.08X10 9/L, N 66.1%, inflammatory markers: ESR 19mm/H, hsCRP 52.3mg/L, PCT 0.52ng/ml, Scr 257μmol/L, and urine routine: WBC 28493/μ. Urinary color Doppler ultrasound: hydronephrosis, bilateral ureteral dilatation, bladder wall thickening significantly; Abdominal pelvic CT: hydronephrosis of both renal pelvis and ureter, thickening of ureter wall (inflammatory change), inflammatory change of bladder and ureter may be large, the volume of both kidneys increases and the substance is thin. Meropenem 1g q12h is given for empirical anti-infection. Urology consultation considers the acute stage of infection, so it is not suitable to put double J tubes. If necessary, pyelostomy can be done, but it does not improve renal function much. Bladder irrigation is recommended. 10-20 middle-stage urine culture (sampling on October 19): Klebsiella pneumoniae was positive; 10-22 urine culture drug sensitivity: Carbapenem-resistant Klebsiella pneumoniae (CRKP), adjusted to ceftazidime and abamectin 2.5g q12h for anti-infection, and daily bladder irrigation. After treatment, the urine color of the patients gradually became clear, and the urine white blood cell and bacterial count gradually decreased during follow-up. The urine bacterial culture was negative on November 1 and November 4. Check the urine routine on November 09: WBC 28/uL, RBC 4/uL, urine protein+,bacterial count 29/UL;Blood WBC 7.64×10 9/L, N 76.5%, hs-CRP 0.4mg/L, ESR 25mm/H, PCT 0.18ng/mL, Scr 175μmol/L, which were significantly improved compared with those at admission. Stop ceftazidime and abamectin on November 11 and be discharged.

On November 15, 2022, the patient appeared turbid urine again, and there was no fever and other discomfort. On November 23, he was admitted to the hospital for a second diagnosis and treatment.

Past history: In September, 1991, T12-L1 comminuted fracture was treated with internal fixation. After operation, the catheter was retained for half a year due to urinary incontinence, and then the catheter was removed after urination. There was no urinary tract infection during this period. Diabetes for 16 years, insulin therapy, blood sugar control can be; Hypertension for 5 years, oral amlodipine to reduce blood pressure, blood pressure control can be.

Second, the admission examination (admitted on November 23, 2022)

[physical examination]

T: 36.2℃ P: 90 times/min R: 20 times/min BP: 176/105 mmHg.

Stay in bed, feel refreshed and calm, lose weight, and muscle atrophy of lower limbs; Breathing sounds in both lungs are thick, and dry and wet rales are not heard; The rhythm of the heart is regular, the abdomen is soft, without tenderness and rebound pain, without mass, without percussion pain in both kidneys, without tenderness at ureter point and rib and waist point, and the lower abdomen does not touch the enlarged bladder. During indwelling catheterization, the urine in the urine collection bag is turbid and more white flocs are deposited. Limbs are not swollen.

[Laboratory examination]

Blood routine: WBC 7.85×10 9/L, N 81.3%, HB 121g/L, PLT 170×10 9/L.

Urine routine: WBC 2775/μ l; RBC 2/μl, bacterial count: 39879/μl, nitrite positive, leukocyte esterase+++.

Inflammation markers: hs-CRP 17.9mg/L, ESR 68mm/H, PCT 0.12ng/mL.

Biochemistry: ALT/AST 23/21U/L, Alb 47g/L, Scr 199μmol/L, eGFR 30ml/min/1.73m2, na/k 140/5.5mmol/l.

Third, clinical analysis

Characteristics of medical history: middle-aged and elderly male, indwelling catheter, with repeated urinary turbidity and abnormal urine routine. Urine culture showed CRKP one month ago, and it improved after ceftazidime-ababactam treatment, but urine turbidity reappeared three days after drug withdrawal, blood inflammatory index increased, urinary leukocyte and bacterial count increased significantly, and the diagnosis of urinary tract infection was clear. The reasons for short-term recurrence after antibacterial drug treatment improved were considered:

Recurrence of CRKP infection: The patient has been indwelling catheter for 2 months, and there may be biofilm formation of catheter and abnormal urinary tract structure, which makes it difficult to completely eliminate the infection and relapse after stopping taking the drug. Therefore, urine culture and drug sensitivity test can be improved.

New infection: the patient has high risk factors of recurrent urinary tract infection, and the pathogen may be different each time. The patient’s previous CRKP infection treatment was effective, and the possibility of new pathogen infection should be considered in the short term, until the urine culture is perfect and clear.

Multiple infections: patients with abnormal urinary tract structure, indwelling catheter and other risk factors can not be removed, so it is necessary to be alert to the possibility of multiple pathogens including fungi combined with infection, repeat the cultivation of urine bacteria, mycoplasma, fungi and mycobacteria, and improve urine mNGS to help clarify the infected pathogens.

Four, further examination, diagnosis and treatment process and treatment response

On November 23, 2022, the middle urine smear was used to find bacteria: moderate amount of G- bacilli, and continued ceftazidime and abamectin 2.5g q12h ivgtt for anti-infection and bladder irrigation.

On November 26, 2022, the bacterial drug sensitivity of the middle-stage urine culture (sampling on November 23) was CRKP, ≥ 100,000 /ml, and urine mNGS: a large number of Klebsiella pneumoniae (species strict sequence number: 406,866) was detected.

On November 29, 2022, the abdominal and pelvic CT was reexamined: bilateral dilated hydronephrosis accompanied with inflammatory changes of ureter, and the parenchyma of both kidneys was thin, and the inflammatory changes of cystitis might be larger, similar to that of 22-10-20 slices.

November 30, 2022 (sampling on November 29): Enterococcus faecalis was positive. On December 2, according to the drug sensitivity, fosfomycin 3g qod was added orally, and ceftazidime and abamectin were suspended.

Repeated urine cultures on March, April and June, December, 2022: Enterococcus faecalis was positive and CRKP was negative.

On December 8, 2022, the urine WBC was 38738/μ L, and the bacterial count was 43285/μ L; Urine culture: CRKP positive, Enterococcus faecalis negative.

Phage therapy was carried out from the afternoon of December August, 2022: Phage cocktail (composed of 5 strains of Klebsiella pneumoniae phages A103KP172, A106KP176, A121KP192, A49KP106 and A58KP118, 5mL each), injected with 225mL physiological saline (according to the estimated bladder volume), and the total volume was 250mL, and then the catheter was clamped.

Urine routine on the third day of phage treatment on December 11, 2022: white blood cell count: 235/uL, bacterial count: 722/uL；; Urine bacterial culture was negative.

Urine routine on the 5th day of phage therapy on December 13th, 2022: white blood cell count: 279/uL, bacterial count: 92/ul; Urine bacterial culture was negative; Blood WBC 6.35X109/L, N 70%, hs-CRP 0.9mg/L, ESR 26mm/H, and inflammatory index decreased compared with before; Re-examination of urinary color ultrasound showed that bilateral renal pelvis separation and upper ureteral dilatation were better than before (10-20), and the thickness of bladder wall was reduced (12-25mm→13mm).

He was discharged from hospital on December 14, 2022 for follow-up.

V. Final diagnosis and diagnosis basis

Final diagnosis:

Complex urinary tract infection (CRKP, Enterococcus faecalis)

Neurogenic bladder, hydronephrosis and hydroureter (indwelling catheter)

Renal insufficiency

Diagnostic basis:

The patient is a middle-aged and elderly male with neurogenic bladder caused by paraplegia, indwelling catheter, turbid urine with flocs, increased CRP and PCT, significantly increased WBC and bacterial count in urine, repeated CRKP positive in urine culture, positive in enterococcus faecalis, abdominal basin CT: hydronephrosis of renal pelvis and ureter, anti-infection, normal inflammatory markers and urine routine after phage treatment, clear urine and negative urine culture, so complicated urinary tract infection.

The patient suffered from anorexia and dysuria, and the serum creatinine increased obviously. Abdominal CT showed that both kidneys were enlarged, the cortex was thin, and bilateral urinary tract was hydronephrosis. After active treatment such as controlling infection and improving renal function, the serum creatinine decreased, so the diagnosis of renal insufficiency was clear.

Six, experience and experience

Phage is a targeted sterilization virus in nature and a sterilization star in the "pre-antibiotic era". Phage therapy has a history of more than 100 years, but the discovery and application of broad-spectrum antibiotics have gradually marginalized it. With the increasingly serious problem of bacterial drug resistance, phages have once again received attention and become the most promising supplement and alternative therapy for treating superbugs. The clinical application of phage in China is relatively late, but it has developed rapidly in recent years. In 2017, the Shanghai Institute of Phage and Drug Resistance was established, with Professor Hu Bijie as an academic member. Since 2018, the institute has carried out the first clinical trial of phage therapy in China. At present, it has treated nearly 100 patients with drug-resistant bacterial infections from all over the country and accumulated rich clinical experience in phage therapy, which is a leading position in the field of clinical phage therapy in China.

Phage has many advantages, such as host bacteria dependence, targeted specific sterilization, no infection to eukaryotic cells (little influence on normal flora), no influence on bacterial drug resistance, synergy with antibacterial drugs, penetration of biofilm and so on. The cure rate of acute bacterial infection is high, and the therapeutic effect of chronic bacterial infection is no less than that of antibacterial drugs, and the safety of phage treatment is also extremely high. A systematic retrospective study showed that the vast majority of patients who received phage therapy had no or only slight adverse reactions, 86.7% patients’ clinical symptoms improved, and 78.8% patients achieved the eradication of pathogenic bacteria. Our clinical trials also show that more than 70% of patients have achieved good therapeutic effects, and there are no obvious cases of adverse reactions. This patient was repeatedly infected with Klebsiella pneumoniae due to long-term paraplegia, abnormal urinary tract structure, indwelling catheter and other factors. The diagnosis of complicated urinary tract infection was unquestionable, and the choice of antibacterial drugs was limited due to multi-drug resistance and renal insufficiency. Phage therapy is very suitable.

The disadvantages of phage therapy include narrow host spectrum, individualized plan (it is difficult to treat empirically), no unified standard for the best treatment decision, and rapid tolerance. Phage cocktails, combined antibacterial drugs and multiple treatments are usually used in clinic to improve the curative effect. At present, the targeted pathogens of phage therapy in our team mainly include: multi-drug resistant Gram-negative bacteria (Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecalis); Covering respiratory system, urinary system, abdominal cavity, bones and joints, skin and soft tissue and other infected sites; Treatment depends on the site of infection, and intravenous application of phage is still being explored. In this case, the patient didn’t have percutaneous nephrostomy because of the little clinical benefit, so he was treated by transurethral bladder perfusion, and the phage could not cover the whole urinary tract evenly. Although the pathogen turned negative in a short period of time and was well tolerated, its long-term curative effect may not be good, and it needs repeated phage treatment.

Phage therapy has huge clinical demand and broad market. In recent years, our team has focused on the clinical application (treatment and prevention and control of nosocomial infection) and basic research of phage therapy, with a view to becoming a powerful weapon to curb drug-resistant bacteria in the future.

references

[1] Uyttebroek S, Chen B, Onsea J, Ruythooren F, Debaveye Y, Devolder D, Spriet I, Depypere M, Wagemans J, Lavigne R, Pirnay JP, Merabishvili M, De Munter P, Peetermans WE, Dupont L, Van Gerven L, Metsemakers WJ. Safety and efficacy of phage therapy in difficult-to-treat infections: a systematic review. Lancet Infect Dis. 2022 Aug; 22(8):e208-e220.

[2] Chegini Z, Khoshbayan A, Taati Moghadam M, Farahani I, Jazireian P, Shariati A. Bacteriophage therapy against Pseudomonas aeruginosa biofilms: a review. Ann Clin Microbiol Antimicrob. 2020 Sep 30; 19(1):45.

[3] Lusiak-Szelachowska M, Weber-Dabrowska B, Gorski A. Bacteriophages and Lysins in Biofilm Control[J]. Virol Sin, 2020,35(2):125-133.

Every Monday night

The Department of Infectious Diseases of Zhongshan Hospital affiliated to Fudan University in Shanghai will be with you!

Photo: Xiaoxiao

Original title: "Detective Case: The Nemesis of Super Bacteria is Coming"

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Xinhua Silk Road, Beijing, September 2 (Reporter Dong Daoyong) "How to enjoy preferential tax agreements? How to prevent overseas tax risks? How to deal with issues such as the collection and management of overseas tax authorities is a huge test for’ going out’ enterprises. " Linlin Chen, finance minister of Ningbo Xinmingda Knitting Co., Ltd. said.

Rules and standards are the bridge and link to promote interconnection. Since the "One Belt, One Road" initiative was put forward, China has taken "soft connectivity" as an important support, steadily expanded institutional opening, and continued to promote cooperation with the co-construction countries in the fields of standards and norms, tax collection and management, intellectual property rights, digital information, etc., and promoted the co-construction of the "Belt and Road" along the direction of high-quality development.

"One Belt, One Road" cooperation in tax collection and management has gone deep and solid.

Taxation plays an important role in the national governance system, playing a fundamental, pillar and supportive role. Because there are many differences in the level of economic development, tax design and the ability of tax collection and management, strengthening coordination and cooperation in the field of taxation plays an increasingly important role in promoting the high-quality construction of the Belt and Road.

In April 2019, the first multilateral tax cooperation platform initiated by China-the "Belt and Road" tax collection and management cooperation mechanism was formally established, which played an important role in strengthening the capacity building of tax collection and management and promoting the construction of a growth-friendly tax environment. At present, the number of members of the Council of the cooperation mechanism has increased to 36, and the number of observers has increased to 30. The "circle of friends" and its influence have continued to expand.

"There are many uncertainties in setting up companies abroad and opening up overseas markets. The difference in tax policies between different countries is a problem we often encounter." Jiang Jingyuan, chief financial officer of China Yituo Group Co., Ltd. said that on the way of "going out", the tax authorities took the initiative to sort out the tax-related guidelines for overseas investment in advance, and provided accurate guidance on the preferential treatment of tax treaties and tax risks involved during the establishment of the company, which solved the worries of enterprise development.

The picture shows the tax bureau of Runzhou District, Zhenjiang City, State Taxation Administration of The People’s Republic of China, going to the "going out" enterprises to publicize the latest preferential tax policies for international taxation.

In terms of "going global", China has signed agreements to avoid double taxation with 112 countries (regions) around the world, which basically covers the main destinations of China’s foreign investment and most of the "Belt and Road" partners, providing a strong tax legal guarantee for "going global" enterprises to eliminate double taxation and resolve cross-border tax-related disputes.

In terms of "bringing in", the electronic tax bureaus of various provinces, autonomous regions and municipalities in China have recently launched the scene of "non-resident cross-border taxation", and non-resident enterprises around the world can apply for tax-related matters online to realize "one place registration and coding, national mutual recognition".

Meng Yuying, director of the International Taxation Department of State Taxation Administration of The People’s Republic of China, said that at a new starting point, the tax authorities will give full play to their tax functions, take the initiative to serve the overall situation of the country, and make greater efforts to help build the "Belt and Road".

The "Belt and Road" standard cooperation is getting closer and closer.

Research by the Organization for Economic Cooperation and Development (OECD) shows that standards and product conformity assessment affect 80% of global investment and trade, and technical standards can promote economic globalization and investment facilitation. Since the "One Belt, One Road" initiative was put forward, the pace of China’s participation in international standards has accelerated.

Bi Shunjie, managing partner of Ernst & Young’s Greater China business, said that the "soft connectivity" of rules and standards is an important support for building the "Belt and Road Initiative" with high quality. Constantly strengthening the construction of international cooperation mechanism is the key to jointly build the "Belt and Road Initiative" and "Soft Unicom".

The picture shows the construction site of the Sino-Thai railway photographed by Nakhon Ratchasima, Thailand. The Sino-Thai Railway is designed and built according to China standards. It is the flagship project of "One Belt, One Road" jointly built by China and Thailand and the first standard gauge high-speed railway in Thailand. (photo of drone, taken on February 23, 2023)

The reporter learned that in order to support the "Belt and Road" high-quality co-construction, the State Administration of Markets took the lead in building the "Belt and Road" national standard information platform, conformity assessment service trade facilitation information platform and technical trade measures public service platform, and promoted the "Belt and Road" to build national standards connectivity.

Since 2014, China has signed 43 standardized cooperation agreements with 36 countries and international (regional) organizations that have jointly established the Belt and Road Initiative, and signed 127 conformity assessment cooperation documents and agreements with more than 30 countries and regions, thus establishing a national cooperation and exchange platform with the Belt and Road Initiative.

"Promoting the" One Belt, One Road "initiative requires continuous pioneering and innovation in all walks of life, and it can also promote the common prosperity of the whole society." Bi Shunjie said that to continuously strengthen the "soft connectivity" of the "Belt and Road" international rules and standards, it is necessary to pay attention to and handle the multi-party relations, especially to give play to China’s guiding role.

"One Belt, One Road" intellectual property cooperation is mutually beneficial and win-win

In the past ten years, China has continuously expanded its opening to the outside world, and the layout of national intellectual property rights jointly built with the "Belt and Road" has been strengthened in both directions. The data shows that in the past ten years, a total of 115 countries that have jointly built the "Belt and Road" have applied for patents in China, with a total of 253,000 patents, with an average annual growth rate of 5.6%.

In 2022, the number of patent applications filed by enterprises in China in the countries jointly building the Belt and Road Initiative reached 12,000, up 16.4% year-on-year. Among them, the number of applications in the three technical fields of motors, electrical devices, electric energy, medicines, materials and metallurgy increased by more than 70% year-on-year. The continuous activity of patent applications shows the vitality of the "One Belt, One Road" initiative.

The picture shows the scene of the first meeting of directors of intellectual property offices in China-Central Asia. The meeting conducted in-depth exchanges on intellectual property cooperation between China and Central Asia and adopted the Joint Statement of the First Meeting of Directors of Intellectual Property Offices in China-Central Asia.

In the past ten years, strengthening communication and cooperation in the field of intellectual property rights has been supported and responded by countries that have jointly built the "Belt and Road". Up to now, China has signed cooperation agreements with 56 national intellectual property management institutions, and promoted the exchange of intellectual property information and business sharing among countries by providing "cloud patent examination" system accounts to nearly 30 countries.

Cai Zhonghua, a professor at beijing university of chemical technology, said that China and the co-construction countries continued to promote technical exchanges and cooperation between the co-construction countries on the basis of deepening intellectual property cooperation agreements and the rapid growth of two-way patent layout, which provided important support for the high-quality development of the Belt and Road Initiative.

　　Northeast Network June 28 News Entering the midsummer, the weather is hot, and drinking cold drinks and eating kebabs has become the first choice for many consumers. A few days ago, the Municipal Food and Drug Administration issued a food safety consumption reminder. The general public should not covet the delicious barbecue food. They should try to choose businesses with complete licenses and good sanitary conditions, and try to choose healthier electric roasting processing methods to be safe.

　　It is understood that eating electric kebabs is healthier than eating charcoal kebabs, because high-temperature cooking or putting food directly on a charcoal fire will produce harmful chemicals such as carbon monoxide, while electric kebabs can effectively control the baking temperature, avoid contact with naked flames, have uniform heat, prevent burning, and greatly reduce the generation of carcinogens. In addition, you should choose grilled kebabs. Some kebabs, though delicious, are difficult to be effectively sterilized due to uneven heating and low central temperature, and may contain pathogenic microorganism residues, which are all hidden dangers. Therefore, kebabs should pay attention to the heat before eating, and citizens should control their high appetite and not eat too much at a time.

　　In addition, if you choose to eat barbecue in the store, you should try to choose a restaurant with complete licenses and good sanitary conditions. If you make your own kebabs, you must keep in mind that fresh ingredients taste good, cut into small pieces and keep them at low temperature. It is necessary to clean the barbecue utensils frequently, and the seasoning is qualified. It is necessary to keep away from charcoal fire and turn them frequently, and smoke flames cannot be roasted.

Original Chen mo mo duo la Wen Yao

Hello, I’m Chen Mo, a clinical pharmacist who wants to fill in all the knowledge of pharmacy.

Now is the outbreak season of influenza. Xiaobian has written several related tweets one after another, but the backstage still receives many readers’ questions, such as: What is the difference between influenza and cold? So, today we will explore this problem together.

01/

What is the flu?

First of all, the flu is a cold, but not all of it.

How can I put it? The full name of influenza is influenza, which is a highly contagious acute respiratory disease caused by influenza virus. Every year, it causes seasonal epidemic in the world, and can cause unpredictable pandemics, with a high incidence rate, posing a huge threat to human health.

To put it bluntly, influenza is an acute respiratory infectious disease with strong infectivity and rapid spread.

According to the antigenicity difference between nucleoprotein and matrix protein M1, influenza viruses can be divided into four types: A, B, C and D, and their characteristics are shown in Table 2.

Influenza viruses can be divided into four types: A, B, C and D (see Figure 1. Click to view a larger image). Among them, influenza A viruses, such as H1N1 and H3N2 subtypes, are more likely to spread rapidly among people because of their easy mutation or rearrangement, and many large-scale outbreaks of influenza in history are related to influenza A viruses.

Fig. 1. Pathogenic classification and characteristics of influenza virus. Photo production: Chen Mo Pharmacist

02/

The common cold

The common cold, which we often say, is a disease confined to the upper respiratory tract. Its clinical manifestations are nasal congestion, runny nose, sore throat and cough, which can be caused by different kinds of virus infections. It is a self-limited disease, and the duration of symptoms is usually less than 10 days.

What are the common causes of the common cold?

The most common is rhinovirus (RV), others are coronavirus, parainfluenza virus, respiratory syncytial virus (RSV), adenovirus and so on.

In addition, human metapneumovirus, enterovirus, mycoplasma pneumoniae and chlamydia pneumoniae infection can also cause cold-like symptoms. Other new respiratory viruses, such as SARS-CoV-2ο and δ mutant, can also be the cause of colds.

Cold like symptoms

Cold symptoms mainly include sore throat, sneezing, headache, general malaise, chills, fever, runny nose, nasal congestion and cough, among which nasal congestion and runny nose are the most prominent symptoms that make patients feel uncomfortable.

03/

The difference between flu and common cold

Here is a table to show (Figure 2. Click to view a larger image):

Figure 2. The main differences between influenza and common cold. Photo production: Chen Mo Pharmacist

——–See you next time.

Original title: "Is the flu a cold? What’s the difference with the common cold? (collectible) "

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CCTV News:A few days ago, the reporter learned from the Ministry of Science and Technology that China has arranged COVID-19 drugs according to a number of technical routes, and formed a variety of key drugs, all of which have entered the clinical trial stage. Experts pointed out that vaccines and drugs are complementary "combination boxing" relationship. In the future, it is inseparable from prevention and control measures, vaccines and therapeutic drugs to fight the epidemic.

China has arranged COVID-19 drugs according to three technical routes: inhibiting virus replication, blocking virus from entering cells and regulating human immune system, and formed a variety of key drugs, all of which have entered the clinical trial stage.

According to experts, the three technical routes of drugs in COVID-19 have their own characteristics, and different strategies are adopted to "block" Covid-19’s infection in different physiological links. Take the inhibition of virus replication as an example. By making a "inferior" nucleotide to "cheat" the virus, making it use this "inferior" material in its own replication, directly blocking replication or making the virus "self-construction" a "unfinished project", virus replication can be successfully stopped. In addition, screening high-quality neutralizing antibodies is also a commonly used strategy. Through single-cell technology, the researchers found the "best soldier" to subdue Covid-19. Finding several kinds of neutralizing antibodies, combined with "cocktail therapy", will have a better therapeutic effect on the mutant strains in Covid-19.

According to statistics, at present, there are six kinds of COVID-19-specific drugs independently developed by China, and the two kinds of neutralizing antibody drugs, BRII-196 and BRII-198, are the fastest, which have been involved in the treatment of more than 700 patients in China. The R&D team has submitted the application materials for conditional listing to National Medical Products Administration on October 9, and it is expected to be approved for conditional listing before the end of December.

At the same time, the neutralizing antibody DXP604 has been used as a "sympathy drug" in beijing ditan hospital when patients have no other drugs available, and some patients have recovered after taking the drug.

After the outbreak of the COVID-19 epidemic, relevant enterprises, scientific research units and scientific and technological personnel in China continued to tackle key problems, and relevant departments cooperated in research and examination, actively promoted the research and development of multi-path drugs, quickly selected a variety of therapeutic drugs, and 31 drugs entered clinical trials, which played an important role in consolidating the achievements of epidemic prevention and control, effectively improving the cure rate and reducing the mortality rate.

Experts said that vaccines and drugs are complementary "combination boxing" relationship. In the future, it is inseparable from prevention and control measures, vaccines and therapeutic drugs to fight the epidemic. COVID-19’s therapeutic drugs, together with effective vaccines, are of great value to the formulation and revision of public policies for prevention and control in COVID-19. In the long run, the emergence of oral drugs has injected a "cardiotonic agent" into the world. With the cooperation of drugs, the pace of world opening and economic recovery will be accelerated.

　　Cctv newsOn April 28th, the joint prevention and control mechanism of the State Council held a press conference to introduce the development of agriculture and rural economy during the epidemic and answer questions from reporters.

　　The reporter asked how to promote agricultural production and green development as a whole.

Liao Xiyuan, Director of Science, Technology and Education Department of Ministry of Agriculture and Rural Affairs

　　Liao Xiyuan, director of the Department of Science, Technology and Education of the Ministry of Agriculture and Rural Affairs, said that in recent years, the Ministry of Agriculture and Rural Affairs has thoroughly implemented the new development concept, put the green development of agriculture in a prominent position, and promoted reduction and efficiency, green substitution, planting and breeding cycle and comprehensive management, and achieved remarkable results. The use of chemical fertilizers and pesticides is less, the manure in the pigsty becomes treasure, the straw is used better, and the recovery rate of agricultural film is higher. This year, we will continue to adhere to the direction of green agricultural development and further intensify our work.

　　First, focus on strengthening policy support. Improve the green-oriented agricultural subsidy system, improve the agricultural ecological compensation mechanism, and improve the management methods such as reducing the use of agricultural inputs, classified management of cultivated land, and conservation of agricultural resources.

　　The second is to focus on implementing the five major actions of agricultural green development. Carry out the action of replacing chemical fertilizer with organic fertilizer in 175 counties in the advantageous production areas of fruit, vegetable and tea; Implement the action of recycling manure in 685 livestock production counties; Implement comprehensive utilization of straw in 200 counties; Implement agricultural film recycling operations in 100 counties; Take the Yangtze River Basin as the focus, and carry out aquatic life protection actions.

　　The third is to focus on strengthening scientific and technological support. Deepen cooperation in Industry-University-Research, organize superior scientific research units and enterprises, carry out joint research on key technologies of agricultural eco-environment, release major leading agricultural green production technologies, and promote 100 leading technologies with high quality, safety, cost saving, high efficiency and eco-friendliness.

　　The fourth is to focus on improving the monitoring network. Weave a "net" for agricultural ecological environmental protection monitoring, improve 40,000 national monitoring points such as cultivated land soil environmental quality, 240 farmland nitrogen and phosphorus loss, 500 agricultural film residues and 280 straw resources, strengthen monitoring and evaluation, and promote supervision and assessment in an integrated manner.

Special feature of 1905 film network　　　In the 47th week of 2018 (from November 19th to November 25th), the market data decreased slightly from last week, closing at 880 million. In recent days, "Nobody", which has been continuously fermented by word of mouth, successfully achieved a counterattack, and reached the top with nearly 280 million results in the second week under the attack of a number of foreign films; The old film Venom is still strong, winning the runner-up with 250 million; The third place was won by the new film "Invincible Destroyer 2: Make a scene on the Internet". At the same time, big data shows that the annual box office in the mainland finally surpassed the previous year this Sunday, breaking through the 55.9 billion mark 36 days ahead of schedule and moving further towards the goal of 60 billion for the whole year.

Word-of-mouth fermentation of "Nobody" reached the top, and "Invincible Destroyer 2" commented on two poles.

At the early stage of its release, The Nobody was angry with a wave of existence because its score continued to rise after the opening of the painting. However, due to the opponent’s "Fantastic Animals: The Crime of Grindelwald", the box office of the former was still suppressed. However, in the next week, with the continuous strong fermentation of word of mouth, the popularity of "Nobody" gradually surpassed that of "Fantastic Animals", and the box office also rose. Since it overtook Venom on Wednesday, the film has been firmly at the top of the list, and even the newly released Disney animation "Invincible Destroyer 2: Make a scene on the Internet" failed to shake it. At present, the box office of the film has quietly approached 350 million, and the spring of good actors has taken another head in this cold winter.

For six years,Wreck-It RalphLaunch a sequel. With the human society stepping into the Internet 2.0 era, the protagonists in movies have also gone from the video game world to virtual cyberspace. This high degree of synchronization between life and the plot makes the stalks in Invincible Destroyer 2: Make a scene on the Internet more entertaining. At present, the film has a good reputation, with Douban score of 8.4 and ticketing platform score higher than 9, so ordinary viewers can find endless fun in the overwhelmed eggs. However, for many fans who have been waiting for "wreck-it ralph" for many years, the story of the sequel seems to be not as amazing as it was when it was first seen in those years. Many people think that the high degree of pan-entertainment has damaged the depth of the plot, which is a pity. This is also a common contradiction in sequel to the movie’s continuous creation.　

The annual box office exceeds 55.9 billion, breaking the 2017 record. Can the mainland film market reach 60 billion in 2018?

This Sunday afternoon, the mainland film market ushered in exciting good news. 36 days before the end of the year, the mainland box office successfully broke through 55.9 billion yuan, setting a new record set last year and starting to move on to new goals. Looking back on the past 11 months, we have not only experienced the absolute glory of the Spring Festival file to help break through 10 billion yuan in a single month, but also the summer file with a high of 16.3 billion yuan, and also survived the shock that the box office continued to fall in a single week and the overall market was cold. Next, the suspense left for 2018 is whether the 60 billion target can be achieved in the next 30 days.

As we all know, the popular lunar new year’s eve file started in December. In 2017, the mainland film market won nearly 5.1 billion in that month, including 11 films that broke 100 million. Looking at the film list, the popular films that have been booked at present include Neptune, Chinese Partner 2, Wulin Monster, Amateur Agent, Spider-Man: Into the Spider-Verse, Weather Pre-explosion, Legend of Ip Man: Zhang Tianzhi, Worm Valley in Yunnan, The Last Night on Earth, etc. Theoretically, it is possible to achieve the goal.

Week 48: Crazy Rich Asians’s old film showing the grievances of the giants is expected to continue to attract gold.

Among the new films opened this week, Crazy Rich Asians has the highest topic. The original English name of the film is Crazy Rich Asian, which tells the story that Rachel, an ordinary girl, accidentally learns that her boyfriend’s family is a super invisible rich while accompanying her boyfriend home to visit relatives, and then faces a series of tests. As an all-Chinese work, the film has also caused extensive discussion in Hollywood after its release. The global box office of $260 million also made this film "the light of Chinese". From the story point of view, this is a high-level inspirational version of Meteor Garden, which is entertaining and educational, and it is a "cool film" that can relax the brain.

There are not many other works of the same period, and many old films released this week still have a chance to attract gold for a week.

　　[PConline evaluation]As a niche old brand, "800 million time and space" seems more like a sentimental existence to some old users. Since the brand was founded in 1992, it has been committed to the PC market. In 2001, it was among the top ten famous brands in China. After the subsequent transformation, it engaged in the research and development and production of liquid crystal display materials, became the main domestic liquid crystal material provider, and gradually faded out of the consumer market.

　　Until this year, Huishijie Electronics Co., Ltd. was authorized by the brand in the field of 800 million time and space display, and the "800 million time and space" products returned to the PC market. BM320F is the masterpiece of big screen, with 32-inch IPS-ADS panel and 10.7mm slim steel frame, which strives to bring strong visual impact to consumers in both display effect and appearance.

● Monitor specification parameters

　● Introduction to the features of BM320F in 800 million time and space:

　　The above table lists the basic parameters and features of this new product. You can read it in detail to deepen your understanding of this product. Let’s start with PConline and make a detailed evaluation of it.

Appreciation of appearance and details of BM320F in 800 million time and space;

　　800 million time and space BM320F is a 32-inch large-screen display, which is made of IPS-ADS panel material, closely follows the fashion trend in appearance, and incorporates the minimalist design concept and extremely narrow bezel, making this display more eye-catching.

　　The clean back is made of matte texture, and the screw holes on the back indicate that this large-screen monitor supports wall hanging function.

　　BM320F will make the fuselage thickness 10.7mm in 800 million time and space, and the slim design will make the fuselage light and thin. Aluminum alloy middle frame is used around the screen to ensure the strength of the fuselage.

　　The border of the 800 million-hour BM320F is one of its appearance features. The super-large screen size is matched with the extremely narrow border of only 6.7mm, so that the line of sight is not limited by the border, thus having a better view.

　　BM320F in 800 million time and space puts the physical OSD button at the back of the display with the logo on the front, which is both beautiful and convenient to operate.

　　Electroplated aluminum alloy die-casting base, beautiful luster, showing gorgeous and elegant temperament.

　　In terms of interface, it is equipped with two common video input interfaces, DVI and VGA, which basically meet the needs of users for multi-platform access.

　　According to the nameplate information, the power of this 32-inch large-screen monitor is only 35W, and its energy-saving and environmental protection features make it suitable for bulk purchase in Internet cafes, offices and other places.

● Gray scale test

　　Gray scale refers to the hierarchical relationship between the darkest black and the brightest white of a display. In terms of contrast between light and dark and black and white color transition, the clearer the image, the more natural the transition, the better. On the gray scale, the performance of 32-level gray scale and 256-level gray scale is mainly used for testing.

　　In the 32-level gray-scale real shot, the color scale display of BM320F in 800 million time and space is relatively general, although there is no obvious color difference, and the gradient range is small. The boundary of some color blocks in the upper left corner is not clear, so it is difficult to distinguish.

　　However, it performed well in the 256-level gray scale test. It can be seen from the real shot that this gray scale gradient has a wide transition range, and the transition is more natural and distinct than the 32-bit gray scale, and most of the squares are completely displayed.

● Test

　　In terms of color saturation, the brighter and more transparent the picture displayed by the display, and the smoother the transition, the better the performance, and vice versa.

　　800 million time BM320F adopts IPS-ADS panel, which has good performance in color saturation, clear image quality and full color. Excessive is natural, and the color has high permeability.

● Test

　　In the real shot, there are slightly dark areas on the left and right edges of BM320F screen in 800 million time and space, but the overall dark part is not obvious, which is good enough for a 32-inch screen.

　　There is no light leakage at the edge of the screen when the monitor is in a real black picture. Excellent performance.

● Contrast test of image restoration effect

　　The following chart is a comparison between the real shot and the original picture, from which we can basically see how the color reproduction effect of a display is.

　　Note: Due to the shooting of the camera, there will be some loss in the real shot picture, and the style of the picture will be different due to the different cameras. Here is for basic reference only.

　　It can be seen from the comparison chart of the color reproduction effect of the picture that the BM320F display in 800 million time and space has a deep reproduction of the red in the three primary colors, and the other colors are still more accurate; In the natural scenery picture test, the color of the safflower picture is biased, and the color is more orange. The green plant map is slightly brighter; The ultra-high contrast of this monitor is excellent in LCD pictures, which can highlight the details of the picture. The character’s skin color is slightly brighter, and the overall restoration effect is more natural and delicate.

● Measured data of BM320F display in 800 million time and space.

　　The 800 million space-time BM320F adopts IPS-ADS high-definition panel, and the viewing angle can reach 178. From the real shot pictures, the multi-view images are uniform, the colors are consistent and the brightness distribution is uniform. It can easily meet the viewing needs of users from different angles.

● Display brightness | Contrast | Color gamut | Color temperature | Color level | Brightness uniformity test

　　The following data were tested by the professional monitor screen color correction instrument "Starscream Spyder4Elite 4". The test items include color gamut coverage, color reproduction accuracy, color temperature consistency, chromaticity uniformity, brightness uniformity, gamma curve and so on.

Color temperature of ambient light: 6500K K.

Ambient light illumination: 51Lux

Signal input: DVI

Comply with ISO3664 standard.

● Color gamut test:

Color gamut coverage: 97% sRGB 76% AdobeRGB

　　After measuring the color gamut of this monitor, it is found that its sRGB color gamut can reach 97% and Adobe RGB color gamut can reach 76%, and the color gamut coverage is relatively normal, which basically meets the needs of mass users for color diversification.

● Brightness uniformity test

　　According to the brightness uniformity test, the brightness value of 225.1cd/㎡ in the center of BM320F is the highest, while the brightness value in the lower left corner is the lowest, which is 198.3cd/㎡, and the brightness difference is 12%. Compared with the 32-inch screen, the overall uniformity is controlled in an acceptable range, and the overall screen display is even and soft.

● Color temperature consistency test:

　　The purpose of color temperature consistency test is to test the stability of white point color temperature of display under different brightness.We test the brightness of all-white picture and all-black picture as well as chromaticity coordinates when the brightness level is 0%, 25%, 50%, 75% and 100% respectively, and calculate the contrast and color temperature values. The color temperature value and contrast ratio should not change much under each brightness.

　　In 800 million time and space, the white point color temperature of BM320F is kept at 7300K under different brightness, and the performance is very stable. Compared with the standard 6500K color temperature, the overall display effect is slightly cooler.

● Color standard test

　　In terms of color accuracy, Δ E value is regarded by us as a key indicator to measure the quality of a product, Δ The closer e is to 1, the more accurate the color standard is. The average of this monitor Δ E is only 1.11, which is very close to the standard level, and the overall performance is excellent. And Δ The maximum value of e is only 3.81, which shows that this monitor has a high level of accuracy in color reproduction.

When △E≤ 1, the human eye can hardly distinguish the difference between the two colors;
When 1<△E<3, the human eye needs to be able to distinguish subtle color differences after comparison;
When △E<5, the human eye can distinguish the color difference and consider it as two similar colors.
When △E>5, most people can see the color difference and think it is a completely different color.

Summary of PConline evaluation room:

800 million time and space BM320F　　picture　　evaluating　　forum　　quote

　　As a large-screen display suitable for Internet cafes and home audio-visual entertainment, the 10.7mm slim body and 6.7mm ultra-narrow bezel of the 800 million-hour BM320F, supplemented by baking paint, have a noble and simple appearance. In terms of screen display, the performance of BM320F is also remarkable. IPS-ADS panel provides ultra-wide visual range and 16.7M color number display, and the performance of color reproduction accuracy is in the upper-middle level.

　　800 million time and space, after many years to return to the consumer market, not only to reconsider the current market demand, but also to get consumer recognition of its brand. Therefore, 800 million time and space promised to provide an effective warranty for BM320F for up to three years, so as to dispel users’ concerns about product quality. At present, the price of this product is 1299 yuan, which is very cost-effective. Friends who like to pursue big-screen entertainment may wish to consider it.

　　On April 11th, 2018, the Central Committee of the Communist Party of China and the State Council issued the Guiding Opinions on Supporting Hainan’s Comprehensive Deepening of Reform and Opening-up. Subsequently, the Ministry of Transport set up a working group to promote the comprehensive deepening reform and opening up of Hainan’s transportation, and planned ahead and took the initiative to dock with unconventional ideas and support. On July 25 of the same year, the Ministry of Transport issued an implementation plan for implementing the Guiding Opinions, which took the lead in sounding the horn of the central state organs to support Hainan’s comprehensive and deepening reform.

　　Over the past year, a series of reforms, initiatives and explorations in the field of transportation have added infinite vitality to Hainan. Today, 26 specific policies and measures and 76 key tasks proposed in the implementation plan are taking root in Hainan, and 12 tasks have achieved initial results.

Haiwen bridge

　　As the largest special economic zone in China and a relatively independent geographical unit, Hainan’s economic aggregate and population size are relatively small, and policy risks are easy to control, which has the unique advantage of becoming an experimental field. Opening the "last mile" of the comprehensive transportation corridor and building an integrated transportation system covering Hainan’s land area and 2 million square kilometers of marine land will accumulate valuable experience for comprehensively promoting the construction of a transportation power.

　　In the implementation plan, the positioning of "comprehensively deepening the reform of transportation, expanding the opening-up pilot area and building a transportation power" has given Hainan an important mission to demonstrate and lead.

　　Infrastructure comes first. "We fully support Hainan to accelerate the construction of a safe, convenient, efficient, green and economical modern comprehensive transportation infrastructure network." The relevant responsible comrades of the working group of the Ministry of Transport to promote Hainan’s comprehensive and deepening reform and opening up said.

Qiongle Expressway

　　During the Thirteenth Five-Year Plan period, the Ministry of Transport continued to increase its support for Hainan’s transportation. With the joint efforts of the Ministry and the province, Hainan’s modern transportation system has taken shape.

　　However, the effective supply capacity of infrastructure is still insufficient, and the energy level and level of airports and seaports in the global aviation and maritime network nodes are low, and there are still shortcomings in the new national strategic requirements for benchmarking the construction of free trade zones &hellip; &hellip; Pieces of short boards stand out in front of you.

　　How to make up for the shortcomings? The first task put forward in the implementation plan is to guide Hainan to work out the medium and long-term development plan of the comprehensive transportation system with high standards, high positioning and high starting point. Since 2018, the Ministry of Transport has instructed Hainan to actively connect with the traffic plan of Guangdong-Hong Kong-Macao Greater Bay Area, and to prepare this plan with high standards, high positioning and high starting point.

　　According to the preliminary research results, the spatial layout of infrastructure with "one belt, two sectors, three vertical connections and four horizontal connections" is coming to the fore.

　　Plan the path and point out the direction. In 2018, the Ministry of Transport increased financial support for Hainan’s transportation infrastructure construction, accelerated the construction of Qiongzhong-Ledong, Wenchang-Qionghai and Wanning-Yangpu expressways, promoted the construction of Wenchang-Lingao Expressway and Haiwen Bridge (Puqian Bridge), the waterway and breakwater project in Macun Port Area of Haikou Port, and carried out the preliminary work of Sanya New Airport and other projects.

　　One by one, the projects under construction and planned to be built have gradually formed the framework of Hainan’s modern comprehensive transportation infrastructure network. In September 2018, an important part of the "Tian" shaped expressway network in Hainan Province &mdash; &mdash; Qiongle Expressway was completed and opened to traffic, and the middle line expressway was fully connected. On March 18th this year, Haiwen Bridge was opened to traffic, shortening the driving time from Haikou City to the famous hometown of overseas Chinese, Wenchang Puqian Town, from one and a half hours to 20 minutes.

Developed expressway network

　　On April 13, 2018, General Secretary of the Supreme Leader solemnly announced at the celebration of the 30th anniversary of Hainan’s establishment of a provincial special economic zone that the CPC Central Committee decided to support the construction of a free trade pilot zone throughout Hainan and the gradual exploration and steady promotion of the construction of a free trade port with China characteristics.

　　Hainan has ushered in a new world of deepening the all-round opening-up in the field of international shipping, the integration of port and shipping and the "streamline administration, delegate power, strengthen regulation and improve services" reform, and it has also ushered in the greatest opportunity for development and the strongest comparative advantage.

　　"Promote Hainan to stand out in the national maritime opening up, create a market environment that comprehensively deepens reform and is highly open, form a competitive advantage, and attract global maritime resources to gather!" The Ministry of Transport has a firm attitude.

　　To this end, the Ministry of Transport has promoted Hainan to take the lead in fully opening up the field of international shipping, allowing foreign businessmen to set up wholly-owned enterprises or joint ventures with unlimited share ratio in Hainan to operate various international shipping and auxiliary businesses such as international shipping and international ship management. Cooperate with relevant parties, the Ministry of Transport will copy and promote all the existing pilot policies for expanding and opening up the free trade zone to Hainan, and guide it to implement the negative list management system of national treatment plus investment before foreign investment access; For international shipping agencies registered in Hainan, the limit of foreign-funded shares not exceeding 51% shall be abolished.

　　The Ministry of Transport also supports Chinese-funded non-five-star Red Flag ships to carry out coastal piggyback business with the port of Hainan Free Trade Zone as an international transit port, study and explore a more open international ship registration system in Hainan, and promote the sharing of relevant certificate information in ship inspection, maritime affairs, port and shipping departments.

　　Most of the world’s free trade zones and free trade ports are built on the basis of Hong Kong and prospered because of it. The implementation plan proposes to focus on supporting Haikou Port and Yangpu Port to become better and stronger, and Sanya, Basuo and Qinglan ports to make their own characteristics.

　　On July 2, 2018, the Hainan Provincial Government signed a strategic cooperation agreement with COSCO Shipping Group to support COSCO Shipping to take the lead in integrating Hainan’s port and shipping resources. At the end of that year, Hainan, the "new channel for international land and sea trade", was launched and COSCO Shipping "Hainan &mdash; The maiden voyage of the ASEAN (Singapore) liner route stirred up waves at sea level.

　　The data shows that in 2018, the port cargo throughput of Hainan Province reached 183 million tons, and the container throughput reached 2.4 million TEUs, up 14.7% year-on-year; The number of international container liner routes increased to 9, and the number of domestic container liner routes increased to 33.

Haikou port

　　The vision turned to Qiongzhou Strait in the north of Hainan Island.

　　In the Spring Festival of 2018, a continuous fog that has not happened in 67 years came unexpectedly. The navigation of passenger ro-ro transportation in Qiongzhou Strait was limited, tens of thousands of cars were stranded in Haikou, and more than ten kilometers of Binhai Avenue became a parking lot. The long wait makes tourists feel anxious. This concentrated on exposing the shortcomings and pain points of passenger ro-ro transportation in Qiongzhou Strait.

　　The pain point is where the force is exerted.

　　The Ministry of Transport, together with Hainan, Guangdong and Guangxi provinces, issued the "Three-year Action Plan for Improving the Passenger Ro-Ro Transport Service Capacity in Qiongzhou Strait (2019&mdash; 2021), actively promote liner operation, study and promote the "separation of passengers and cars" on boarding and disembarking, and urge relevant port and shipping enterprises to launch WeChat WeChat official account ticketing services. During the period of Spring Festival travel rush in 2019, the passenger ro-ro transportation in Qiongzhou Strait provided efficient, convenient and high-quality services for people traveling between the two sides of the strait, and safely transported 3.6 million passengers and 750,000 vehicles, without serious detention of passengers and vehicles.

　　Streamline administration, delegate power, strengthen regulation and improve services’s reform of transportation in Hainan Province has also gained more support. In 2018, Hainan achieved 64 items of "no face-to-face approval" ahead of schedule, and the "commitment time limit" of 80 administrative examination and approval items involved was all reduced by 50%.

　　On January 31st, "Westdan", a world-renowned cruise company owned by Holland America Cruises, arrived in Sanya, becoming the first international cruise ship to visit Sanya this year, bringing in 1,855 inbound tourists, of which about 85% were from Europe and America, which became a story of the handover between Sanya’s tourism industry and the world cruise industry.

Sanya Phoenix Cruise Terminal

　　Nowadays, cruise yacht tourism has become the most dazzling business card of Hainan tourism and an emerging industry with characteristics, potential and competitiveness.

　　As the only tropical island province in China, Hainan has a unique resource advantage in developing cruise yacht industry. Under the guidance of the Guiding Opinions, Hainan’s road to building an international tourist island is getting wider and wider.

　　The implementation plan proposes to support cruise enterprises to develop cruise routes involving Hainan, advance the pilot of Hainan cruise destination routes, support the development of local cruise ships, and expand Hainan cruise market.

　　Today, these measures are being gradually implemented. The Ministry of Transport took the lead in guiding Hainan to introduce preferential policies to promote the agglomeration of cruise elements, researching and formulating pilot policies for Chinese-funded flag of convenience cruise ships at sea, supporting cruise ports such as Sanya to carry out pilot projects, extending the yacht free travel policy of Guangdong, Hong Kong and Macao to Hainan, establishing a yacht type inspection and filing management system, and promoting the establishment of a port management model of "fixed-point docking and joint inspection nearby" for yachts from Qiong, Hong Kong and Macao.

　　Yacht go on road trip, as a new format of yacht tourism development, is "hot" again.

　　Since the development of yacht industry can drive the development of upstream and downstream service industries to a certain extent, the implementation plan proposes to carry out pilot work for the approval of temporary open waters for overseas yachts, explore the free travel of yachts from Qiong, Hong Kong and Macao, and solve the bottleneck problem that restricts the development of yacht industry in Hainan.

　　In this regard, the Ministry of Transport has studied the pilot project of decentralized approval, and approved the yacht free travel plan of Hong Kong, Macao and go on road trip in conjunction with national port inspection and inspection units such as the General Administration of Customs and the State Administration of Immigration, focusing on solving the problems of insufficient navigation waters and tight supervision faced by yachts from Hong Kong, Macao and overseas, so as to ensure that yachts can really get in and swim.

　　At present, there are 2 cruise terminals in Hainan, 8 yacht manufacturing enterprises registered in Hainan and 146 yacht sales and service enterprises. Twelve yacht marinas and 1,658 berths have been built and operated.

　　The insiders believe that in the next 10 to 15 years, China’s cruise yacht industry will develop rapidly, and Hainan will have greater achievements.

　　The CPC Central Committee and the State Council have given Hainan the position of "three districts and one center", one of which is the "National Major Strategic Service Guarantee Zone", and Hainan will play an indispensable guarantee function in the national strategies such as the "Belt and Road" construction and the development of integration of defense and civilian technologies.

　　As a "crossroads" at sea, the South China Sea is an important international maritime transport channel and a maritime hub connecting the Pacific Ocean, the Indian Ocean and the three continents of Asia, Africa and Europe. In recent years, with the strong support of the Ministry of Transport, the maritime search and rescue and emergency capacity building in the South China Sea has achieved remarkable results, which has played an important role in ensuring the safety of navigation and serving the construction and development of the South China Sea, but it is still difficult to meet the needs of maritime emergency support.

　　In view of the shortcomings of maritime search and rescue and emergency response capacity building in the South China Sea, the implementation plan proposes to improve the rescue support system in the South China Sea, with the aim of ensuring transportation and controlling safety risks, and improving the ability to prevent and respond to severe weather conditions such as typhoons, so as to serve the implementation of major national strategies.

　　Over the past year, Hainan Maritime Search and Rescue Center has initially established a maritime search and rescue cooperation mechanism with Hong Kong and Macao. The construction of South China Sea Maritime Rescue Base and South China Sea Rescue Force has been accelerating, and the maritime supervision base and Haikou Rescue Base have been completed and put into use. The construction of a 14,000-kilowatt large cruise rescue boat is accelerating; Maritime affairs, salvage and other related units have carried out four joint cruises of sea and air, including the waters south of Sanya and the waters west of the Greater Sanya Tourism Circle, and explored the establishment of a normalized three-dimensional cruise mode of sea and air that is suitable for the South China Sea.

　　Taking on the responsibility of the special zone, Hainan has been innovating constantly and moving towards the deep-water area of the national strategy of service guarantee.

　　In the field of service "Belt and Road"Hainan has accelerated the construction of the "Belt and Road" air-sea bridge. At present, 74 international (regional) air routes have been opened, and the number will be increased to about 100 in the next two years.

　　In the field of serving the "new channel of international trade by land and sea"Taking Yangpu Port as a pilot, Hainan will focus on building an international transit hub port facing Southeast Asia, and build a foreign trade route network that starts from Hainan and reaches major logistics nodes in Singapore and ASEAN, and then radiates to Southeast Asia, South Asia and the Middle East.

　　"Wan Li’s spring scenery is bright." With the support of the Ministry of Transport, Hainan will surely stand on the forefront and shine brilliantly.

　　CCTV News:In order to further enhance people’s awareness of network security, according to the deployment of "Net Net 2022" special action, the network police brigade of Zhong Kai High-tech Zone Branch of Huizhou Public Security Bureau and volunteers from Shuguang Community of Chen Jiang Street went deep into the community to carry out network security publicity activities to popularize network security knowledge and practical prevention skills for people in the area.

　　At the activity site, the Cyber Police Brigade and volunteers from Shuguang Community in Chen Jiang, by hanging propaganda banners, setting up propaganda desks and distributing publicity materials, publicized the police mainly around the common network traps, online fraud methods and personal information protection methods in real life, popularized the protection skills to the masses, patiently answered questions for the masses, and reminded them to enhance their awareness of self-protection and jointly created a harmonious, safe and stable network environment.

　　It is understood that this publicity campaign distributed more than 300 brochures and received more than 40 consultations from the masses, which effectively improved the public’s awareness of network security and basic protection skills and played a positive role in creating a safe, harmonious and stable network environment in the whole region. (General Desk reporter Yang Zhen)